Darunavir Ethanolate CAS 635728-49-3 Mimọ ≥99.0% API Factory Anti-HIV HIV Protease Inhibitor
Ipese Olupese Awọn ọja ibatan Darunavir:
Daunavir CAS 206361-99-1
Darunavir Ethanolate CAS 635728-49-3
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| Orukọ Kemikali | Darunavir Ethanolate |
| Awọn itumọ ọrọ sisọ | DRV;Prezista;TMC114 Ethanolate;UNII-33O78XF0BW;N-[(1S,2R) -3-[[(4-Aminophenyl) sulfonyl] (2-methylpropyl) amino] -2-hydroxy-1- (phenylmethyl) propyl] carbamic acid (3R,3aS,6aR) -hexahydrofur [2,3-b]furan-3-yl ester compd.pẹlu ethanol |
| Nọmba CAS | 635728-49-3 |
| NỌMBA CAT | RF-API69 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
| Fọọmu Molecular | C29H43N3O8S |
| Òṣuwọn Molikula | 593.73 |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Pa-White Crystalline Powder |
| Idanimọ IR | Ni ibamu si awọn Standard julọ.Oniranran |
| Yiyi pato | -0.5°~ +0.5° |
| Awọn nkan ti o jọmọ | (nipasẹ HPLC) |
| Max Nikan Aimọ | ≤0.20% |
| Lapapọ Awọn Aimọ | ≤0.50% |
| Omi (KF) | ≤1.0% |
| Aloku lori Iginisonu | ≤0.10% |
| Awọn irin Heavy | ≤10ppm |
| Akoonu ti Ethanol | ≤7.5% (GC) |
| Awọn ohun elo ti o ku | Methanol ≤0.30% |
| Mimo | ≥99.0% (HPLC) |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Darunavir Ethanolate HIV-1 Protease Inhibitor Anti-HIV Antiviral |
Package: Igo, apo apamọwọ Aluminiomu, Ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Darunavir Ethanolate (Prezista) jẹ oludena protease HIV kan.Itọsẹ ti Darunavir, iran keji HIV-1-protease inhibitor;structurally iru si amprenavir.Antiviral.O jẹ ọja iwadii ti o ni ibatan COVID19.Laanu, DRV ni solubility kekere ninu omi ati ailagbara bioavailability, nitorinaa o nilo iṣakoso ni awọn iwọn lilo ti o ga pupọ lati le ṣe afihan ipa itọju ailera.Darunavir jẹ inhibitor agbara ti o gbooro ti o n ṣiṣẹ lodi si awọn ipinya ile-iwosan HIV-1 pẹlu cytotoxicity ti o kere ju.Darunavir ṣe agbekalẹ awọn ifunmọ hydrogen pẹlu awọn itọmu pq akọkọ ti a fipamọ ti Asp29 ati Asp30 ti protease.Awọn ibaraenisepo wọnyi ni a daba lati jẹ pataki fun agbara ti agbo-ara yii lodi si awọn ipinya HIV ti o tako si awọn inhibitors protease pupọ.Ninu iwadi in vitro ninu awọn sẹẹli MT-2, agbara darunavir tobi ju ti saquinavir, amprenavir, nelfinavir, indinavir, lopinavir ati ritonavir lọ.Darunavir jẹ metabolized nipataki nipasẹ awọn ensaemusi cytochrome P450 (CYP), nipataki CYP3A.Iwọn 'igbelaruge' ti ritonavir n ṣe inhibitor ti CYP3A, nitorinaa jijẹ bioavailability darunavir.A ṣe Darunavir lati ṣe agbekalẹ awọn ibaraẹnisọrọ to lagbara pẹlu enzymu protease lati ọpọlọpọ awọn igara ti HIV, pẹlu awọn igara lati awọn alaisan ti o ni iriri itọju pẹlu mutati resistance pupọ.
