Decitabine CAS 2353-33-5 Mimọ> 99.5% (HPLC) Ile-iṣẹ
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ati olupese ti Decitabine (CAS: 2353-33-5) pẹlu didara to gaju.A le pese COA, ifijiṣẹ agbaye, kekere ati titobi pupọ ti o wa.Ti o ba nifẹ si ọja yii, jọwọ firanṣẹ alaye alaye pẹlu nọmba CAS, orukọ ọja, opoiye si wa.Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Decitabine |
| Awọn itumọ ọrọ sisọ | 5-Aza-2'-Deoxycytidine;5-Aza-1- (2-Deoxy-β-D-Ribofuranosyl) cytosine;5-Aza-CdR;5-Aza-dC;5-Deoxy-2'-Azacytidine;ZdCyd;DAC;β-Decitabine |
| Nọmba CAS | 2353-33-5 |
| NỌMBA CAT | RF2728 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C8H12N4O4 |
| Òṣuwọn Molikula | 228.21 |
| Ojuami Iyo | 191 ℃ (oṣu kejila) |
| Ni imọlara | Afẹfẹ Sensitive, Ooru kókó |
| Solubility | Tituka ni DMSO;Die-die tiotuka ninu Omi |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Pa-White Crystalline Powder |
| Idanimọ A | IR: Ayẹwo IR Spectrum ni ibamu pẹlu ti Standard |
| Idanimọ B | HPLC: RT ti Oke nla ti Solusan Idanwo ni ibamu si ti Solusan Standard |
| Idanimọ C | PXRD: rere |
| Mimọ / Analysis Ọna | > 99.5% (HPLC) |
| Alfa | + 56,0 ° ~ 63,0 ° |
| Pipadanu lori Gbigbe | <0.50% |
| Aloku lori Iginisonu | <0.10% |
| Awọn irin Heavy | <20ppm |
| Awọn nkan ti o jọmọ | |
| α-Decitabine | <0.20% |
| Nikan Unknown aimọ | <0.20% |
| Lapapọ Awọn Aimọ | <0.50% |
| Awọn ohun elo ti o ku | |
| DMSO | <0.50% |
| kẹmika kẹmika | <0.30% |
| Methyl Formate | <0.05% |
| Acetonitrile | <0.041% |
| Solubility | Ko ni awọ kuro 50 mg/ml, HOAc ati H2O (1: 1) Pass |
| Igbeyewo Standard | Standard Enterprise |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Bawo ni lati Ra?Please contact: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Russia, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Decitabine (CAS: 2353-33-5) (orukọ iṣowo Dacogen), tabi 5-Aza-2'-Deoxycytidine.Kemikali, o jẹ afọwọṣe cytidine.Decitabine jẹ aṣoju hypomethylating.Decitabine ti ṣe ifilọlẹ fun itọju awọn iṣọn-alọ ọkan myelodysplastic (MDS).MDS jẹ eto awọn rudurudu hematologic ti o ni ipa lori ọra inu egungun ti o ja si idasile ti ko munadoko ati idagbasoke awọn sẹẹli ẹjẹ.Pẹlupẹlu, awọn alaisan ti o ni MDS ni eewu giga ti ilọsiwaju si aisan lukimia myeloid nla (AML).Awọn itọju ti aṣa pẹlu gbigbe ẹjẹ silẹ, awọn okunfa idagbasoke hematopoietic, ati awọn aporo ajẹsara, ṣugbọn awọn iwọn wọnyi kan mu didara igbesi aye pọ si pẹlu awọn ipa ti o ni ibeere lori iyipada arun.Lakoko ti asopo-ẹyin sẹẹli jẹ ibinu, ọna ti o le ṣe itọju, ọjọ-ori ti o ti ni ilọsiwaju tabi awọn ọran ilera ti o ni idiju ti ọpọlọpọ awọn alaisan ni idiwọ fun wọn lati gbero aṣayan yii.Awọn ilọsiwaju aipẹ ni etiology ipilẹ ti MDS, sibẹsibẹ, ti yori si idagbasoke ti kilasi tuntun ti awọn agbo ogun ti a mọ si '' awọn aṣoju demethylating ''.Decitabine tẹle ifihan aṣeyọri ti akọkọ DNA methyltransferase inhibitor Azacitidine.O hypomethylates DNA nipa idinamọ DNA methyltransferase.O ṣiṣẹ ni ọna ti o jọra si Azacitidine, botilẹjẹpe decitabine nikan ni a le dapọ si awọn okun DNA nigba ti azacitidine ni a le dapọ si mejeeji DNA ati awọn ẹwọn RNA.Awọn atunṣe iwadii: Decitabine jẹ lilo pupọ ni isedale molikula, oogun oogun, ati iwadii imọ-jinlẹ miiran.Decitabine gẹgẹbi onidalẹkun DNA methyltransferase kan pato, ilana DNA methylation ti o yipada, awọn sẹẹli tumo si awọn sẹẹli deede lati ṣe iyatọ tabi fa apoptosis sẹẹli tumo.Jọwọ ṣe akiyesi pe ifọkansi giga ti Decitabine yoo mu ipa cytotoxic rẹ ṣiṣẹ: le ṣe idiwọ iṣelọpọ DNA ti o fa iku sẹẹli.
