Entecavir CAS 142217-69-4 API Factory Didara Giga Anti-HBV
Ipese Olupese pẹlu Iwa-mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Entecavir
CAS: 142217-69-4
Oogun egboogi ti a lo ninu itọju Ẹdọ-arun B
API Didara Giga, Iṣelọpọ Iṣowo
Orukọ Kemikali | Entecavir |
Awọn itumọ ọrọ sisọ | 2-Amino-1,9-dihydro-9-[(1S,3R,4S)-4-hydroxy-3- (hydroxymethyl) -2-methylenecyclopentyl]-6H-purin-6-ọkan |
Nọmba CAS | 142217-69-4 |
NỌMBA CAT | RF-API80 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C12H15N5O3 |
Òṣuwọn Molikula | 277.28 |
Ojuami Iyo | 249.0 ~ 252.0 ℃ |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun Crystalline Powder |
Idanimọ IR | Iwọn gbigba infurarẹẹdi ti ayẹwo idanwo gbọdọ jẹ ibamu pẹlu boṣewa itọkasi |
HPLC idanimọ | Akoko idaduro ti ayẹwo idanwo ni ibamu si ti boṣewa itọkasi |
pH | 5.5 ~ 7.5 |
Specific Optical Yiyi | +24.0°-+28.0° (DMF: MeOH=1:1 C=1%) |
Awọn nkan ti o jọmọ | |
Lapapọ Awọn Aimọ | ≤0.30% |
O pọju Nikan Aimọ | ≤0.10% |
Enantomer | ≤0.20% |
Awọn ohun elo ti o ku | |
kẹmika kẹmika | ≤0.30% |
Dichloromethane | ≤0.06% |
n-Hexane | ≤0.029% |
Tetrahydrofuran | ≤0.072% |
N, N-Dimethylformamide | ≤0.088% |
Toluene | ≤0.089% |
Omi akoonu | 5.8% ~ 6.5% |
Aloku lori Iginisonu | ≤0.10% |
Awọn irin Heavy | ≤20ppm |
Ayẹwo | 98.0% ~ 102.0% (C12H15N5O3 ṣe iṣiro lori ipilẹ anhydrous) |
Patiku Iwon | D90: ≤100µm |
Igbeyewo Standard | Standard Enterprise |
Lilo | API, Oogun Agbogun ti a lo ni itọju Ẹdọ-arun B |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Entecavir jẹ iran tuntun ti awọn analogues guanine nucleoside analogues oogun ẹnu fun itọju ti Iwoye Ẹdọ B (HBV), nipataki fun itọju awọn alaisan agbalagba ti o ni iṣẹ ṣiṣe atunwi gbogun ati transaminase omi ara ti tẹsiwaju lati pọ si, tabi àsopọ ẹdọ fun iṣẹ-aisan ti arun jedojedo B onibaje. , Lọwọlọwọ ni isalẹ kokoro ni iyara ati alagbara julọ, iwọn iyipada ti o kere julọ awọn analogues nucleoside.Data fihan pe o yatọ si ni awọn alaisan ti o ni arun jedojedo B onibaje, pẹlu nucleoside naive ati nucleoside mu ati ẹdọ cirrhosis alaisan, lilo daradara entecavir wàláà ninu awọn itọju le šakoso awọn arun nyara ati awọn iṣọrọ de ọdọ awọn itọju ti otito opin, eyun awọn jedojedo B kokoro unmesured;nipasẹ ifaramọ si itọju, ipin pupọ ti awọn alaisan le de opin itẹlọrun itọju, eyun e antigen serology iyipada, diẹ ninu awọn alaisan le paapaa de ibi ti o dara julọ fun itọju ipari, eyun antigen odi.