Entecavir Monohydrate CAS 209216-23-9 API Factory High Quality Antiviral Hepatitis B Ikolu
Ipese Olupese pẹlu Iwa-mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Entecavir Monohydrate
CAS: 209216-23-9
Ti a lo ni itọju Ẹdọ-arun B
API Didara Giga, Iṣelọpọ Iṣowo
Orukọ Kemikali | Entecavir Monohydrate |
Awọn itumọ ọrọ sisọ | Entecavir Hydrate;9-[(1S,3R,4S)-4-Hydroxy-3- (hydroxymethyl) -2-methylenecyclopentyl] guanine Monohydrate |
Nọmba CAS | 209216-23-9 |
NỌMBA CAT | RF-API79 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C12H17N5O4 |
Òṣuwọn Molikula | 295.3 |
Ojuami Iyo | > 220 ℃ |
iwuwo | 1.81 |
Sowo Ipò | Sowo Labẹ Ibaramu otutu |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Fere White Crystalline Powder |
Solubility | Soluble Larọwọto ni Dimethylformamide, Tiotuka Diẹ ninu Omi, Ethanol ati Methanol |
Idanimọ IR | Spectrum ti ayẹwo ni ibamu si ti boṣewa itọkasi |
HPLC idanimọ | Akoko idaduro ti ayẹwo idanwo ni ibamu si ti boṣewa itọkasi |
Akoonu Omi (nipasẹ KF) | 5.5% ~ 6.5% |
Specific Optical Yiyi | +24.0° si +30.0° (DMF: MeOH=1:1 C=1%) (lori ohun elo alaiwu) |
Aloku lori Iginisonu | ≤0.10% |
Awọn nkan ti o jọmọ | |
Furontecavir | ≤0.10% |
Entecavir 1-Epimer | ≤0.10% |
Entecavir 3-Epimer | ≤0.10% |
8-Methyoxy Entecavir | ≤0.10% |
Entecavir 4-Epimer | ≤0.10% |
8-Hydroxy Entecavir | ≤0.10% |
4-Dimethylsilyl Entecavir | ≤0.10% |
Agbo ibatan Entecavir A | ≤0.10% |
Eyikeyi Aisọye Aimọ | ≤0.10% |
Lapapọ Awọn Aimọ | ≤0.30% |
Awọn ohun elo ti o ku | |
kẹmika kẹmika | ≤600ppm |
Dichloromethane | ≤300ppm |
Ethyl acetate | ≤1000ppm |
Tetrahydrofuran | ≤720ppm |
Toluene | ≤890ppm |
Benzyl kiloraidi | ≤1000ppm |
Benzyl Ọtí | ≤1000ppm |
Makirobia Ifilelẹ | |
Lapapọ Awọn iṣiro Aerobic | ≤100cfu/g |
Iwukara ati Molds | ≤10cfu/g |
Escherichia Coli | Ko yẹ ki o wa |
Awọn irin Heavy | ≤10ppm |
Ayẹwo | 98.0% ~ 102.0% (HPLC; lori ipilẹ anhydrous) |
Patiku Iwon | 95% ti awọn patikulu yẹ ki o wa laarin 125um |
Igbeyewo Standard | Standard Enterprise;United States Pharmacopoeia (USP) Standard |
Lilo | Oogun egboogi ti a lo ninu itọju Ẹdọ-arun B |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
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Entecavir Monohydrate (CAS 209216-23-9) jẹ oogun ajẹsara ti ẹnu ti a lo ninu itọju Iwoye Iwoye B (HBV).Entecavir Monohydrate jẹ afọwọṣe nucleoside (diẹ sii pataki, afọwọṣe guanine) ti o ṣe idiwọ transcription yiyipada, ẹda DNA ati transcription ninu vira.O jẹ iru tuntun ti cyclopentyl acyl guanosine awọn oogun ọlọjẹ Hepatitis B pẹlu awọn ipa elegbogi rẹ bii Entecavir.O ti lo ni ile-iwosan si itọju ti agbalagba Chronic Hepatitis B ninu eyiti o wa ni isodipupo gbogun ti nṣiṣe lọwọ, ti o pọ si transaminase ALT tabi awọn egbo ti nṣiṣe lọwọ ti a fihan lati itan-akọọlẹ ẹdọ.Entecavir Monohydrate jẹ apaniyan ti o lagbara ati yiyan ti HBV, pẹlu EC50 ti 3.75 nM ninu sẹẹli HepG2.Entecavir jẹ onidalẹkun transscriptase iyipada.O ṣe idilọwọ Awọn ọlọjẹ Hepatitis B (HBV) lati isodipupo ati dinku iye ọlọjẹ ninu ara.
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