Epalrestat CAS 82159-09-9 Mimọ> 99.5% (HPLC) Ile-iṣẹ
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Epalrestat (CAS: 82159-09-9) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, kekere ati awọn iwọn olopobobo ti o wa.Ra Epalrestat,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Epalrestat |
| Awọn itumọ ọrọ sisọ | Epalrest;ONO-2235;Eabeth;Kinedak;Sorbistat;(5Z) -5- [(2E) -2-Methyl-3-phenyl-2-propen-1-ylidene] -4-oxo-2-thioxo-3-Thiazolidineacetic Acid;2-[(5Z) -5-[(E) -3-Phenyl-2-methylprop-2-enylidene] - 4-oxo-2-thioxo-3-thiazolidinyl] acetic Acid;(E, E) -2- [5- (2-Methyl-3-phenyl-prop-2-enylidene)-4-oxo-2-sulfanylidene-thiazolidin-3-yl] acetic Acid. |
| Iṣura Ipo | Ni Iṣura, Ibi iṣelọpọ |
| Nọmba CAS | 82159-09-9 |
| Fọọmu Molecular | C15H13NO3S2 |
| Òṣuwọn Molikula | 319,39 g / mol |
| Ojuami Iyo | 222.0 si 226.0 ℃ |
| iwuwo | 1,43 ± 0,10 g / cm3 |
| Solubility | DMSO 2 mg/mL Omi <1 mg/mL Ethanol <1 mg/mL |
| Ibi ipamọ otutu. | Itura & Ibi Gbẹ (-20℃) |
| COA & MSDS | Wa |
| Ẹka | API |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Orange to Orange Red Crystalline Powder | Ibamu |
| Idanimọ | Aami si akoko idaduro HPLC ti boṣewa | Kọja |
| Ojuami Iyo | 222.0 si 226.0 ℃ | 222.4 ~ 224.3 ℃ |
| Pipadanu lori Gbigbe | <0.50% | 0.04% |
| Aloku lori Iginisonu | <0.20% | 0.03% |
| Awọn Irin Eru (Pb) | ≤20ppm | <20ppm |
| Lapapọ Awọn Aimọ | ≤0.50% | 0.20% |
| Mimọ / Analysis Ọna | > 99.5% (HPLC) | 99.8% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti edidi ni itura ati ki o gbẹ (-20℃) ile itaja kuro lati awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
UN ID 2811
WGK Germany 3
RTECS XJ5131855
Ewu Kilasi 6.1
Iṣakojọpọ Ẹgbẹ II
Epalrestat (CAS: 82159-09-9) jẹ inhibitor aldose reductase keji lati ṣe afihan ni agbaye ati akọkọ lati ṣe ifilọlẹ ni Japan.Epalrestat jẹ itọkasi fun itọju neuropathy dayabetik.O tun n ṣe iwadii fun retinopathy dayabetik ati nephropathy.Epalrestat jẹ inhibitor aldose reductase pẹlu IC50 ti 72 nM.
Epalrestat ṣe idiwọ Aldose Reductase (AR) ti o ni ipa ninu iwọn idiwọn ni iyipada ti glukosi si sorbitol labẹ awọn ipo hyperglycemic.Aldose reductase ti jẹ ibi-afẹde ti ọpọlọpọ awọn iwadii ile-iwosan lati tọju neuropathy dayabetik ati retinopathy.Epalrestat jẹ oogun ti a fọwọsi ni Japan ati India, ti a lo fun itọju neuropathy dayabetik.
Epalrestat ni a lo lati ṣe idiwọ, ṣe atunṣe, ati itọju neuropathy agbeegbe (numbness, irora), paresthesia gbigbọn, ati aiṣedeede ọkan ọkan ti o ni nkan ṣe pẹlu àtọgbẹ.
Epalrestat gẹgẹbi oogun aṣoju rẹ dinku ikojọpọ intracellular ti fructose ati sorbitol nipa didi iṣẹ ṣiṣe aldose reductase pada, mu pada Na +-K +-ATPase ati iṣẹ inositol, mu didasilẹ KO ni awọn sẹẹli endothelial, ṣe idiwọ protein kinase C ipa ọna ifihan, glukosi sẹẹli endothelial, adhesion cell-giga, neutrophil mediated ati ikosile ifosiwewe ifaramọ endothelial ati dinku awọn ọja lysine carboxymethyl ni awọn alaisan dayabetik, nitorinaa atọju awọn arun bii àtọgbẹ ati awọn ilolu rẹ.
