Fmoc-Leu-OH CAS 35661-60-0 N-Fmoc-L-Leucine Mimọ> 99.0% (HPLC) Ile-iṣẹ
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) pẹlu didara to gaju.Kemikali Ruifu n pese lẹsẹsẹ amino acids.A le pese ifijiṣẹ agbaye, idiyele ifigagbaga, kekere ati awọn iwọn olopobobo ti o wa.Ra Fmoc-Leu-OH,Please e-mail: alvin@ruifuchem.com
| Orukọ Kemikali | N-Fmoc-L-Leucine |
| Awọn itumọ ọrọ sisọ | Fmoc-Leu-OH;Fmoc-L-Leu-OH;Fmoc-L-Leucine;N-[(9H-Fluoren-9-ylmethoxy) carbon]-L-Leucine;N- (9-Fluorenylmethoxycarbonyl) -L-Leucine |
| Iṣura Ipo | Ninu Iṣura, Agbara iṣelọpọ si Awọn Toonu fun oṣu kan |
| Nọmba CAS | 35661-60-0 |
| Ilana molikula | C21H23NO4 |
| Òṣuwọn Molikula | 353,42 g / mol |
| Ojuami Iyo | 153.0 si 160.0 ℃ |
| iwuwo | 1,207 ± 0,06 g / cm3 |
| Ni imọlara | Hygroscopic |
| Solubility ni kẹmika | Fere akoyawo |
| Ibi ipamọ otutu. | Itura & Ibi Gbẹ (2 ~ 8℃) |
| COA & MSDS | Wa |
| Ẹka | Awọn ohun elo Fmoc-Amino |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Awọn abajade |
| Ifarahan | Funfun Powder | Funfun Powder |
| Yiyi pato [α] 20/D | -25.0°±2.0° (C=1 ninu DMF) | -24.6° |
| Ojuami Iyo | 153.0 si 160.0 ℃ | 155.1 ℃ |
| TLC | ≥98.0% | > 98.0% |
| Opitika ti nw | <0.30% D-Enantiomer | Ibamu |
| wípé Solusan | 0.3 giramu ni 2ml DMF Ko Solusan | Ibamu |
| Kaiser igbeyewo | <0.05% | <0.05% |
| Omi nipa Karl Fischer | <0.50% | 0.12% |
| Pipadanu lori Gbigbe | <0.50% (60℃, wakati meji) | 0.15% |
| Fmoc-β-Ala-OH | <0.20% (HPLC) | Ibamu |
| Fmoc-β-Ala-Leu-OH | <0.10% (HPLC) | Ibamu |
| Fmoc-Leu-Leu-OH | <0.10% (HPLC) | Ibamu |
| Fmoc-Ile-OH | <0.10% (HPLC) | Ibamu |
| Assay Free Amino Acid | <0.20% (GC) | Ibamu |
| Ethyl acetate | <0.50% (GC) | Ibamu |
| Mimọ / Analysis Ọna | > 99.0% (HPLC) | 99.85% |
| Ibi julọ.Oniranran | Ni ibamu Pẹlu Standard | Ibamu |
| NMR julọ.Oniranran | Ni ibamu Pẹlu Standard | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato | |
Package: Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti edidi ni itura ati ki o gbẹ (2 ~ 8℃) ile itaja kuro lati awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Ilana ayewo
1. Irisi
- Ayẹwo wiwo
2. Mimo (HPLC)
2.1 Irinse
Kiromatogirafi olomi iṣẹ ṣiṣe giga, aṣawari PDA.
Itanna analitikali iwontunwonsi
2.2 Reagent
Acetonitrile (ipò chromatographic), Trifluoroacetic acid (ipò chromatographic)
2.3 Chromatographic ipo
2.3.1 Ọwọn: YMC-ODS-AM, 5μL, 250x4.6 mm
2.3.2 erin wefulenti: INC220nm
Oṣuwọn sisan: 1.0ml/min
Iwọn ayẹwo: 10μL (itọkasi)
Diluent: acetonitrile
Akoko gbigba data: 25.00min
2.4 Mobile alakoso igbaradi
Mobile alakoso A (0.1% trifluoroacetic acid omi): gba deede 2.0ml trifluoroacetic acid, ti fomi po pẹlu omi si 2000ml, dapọ daradara, ati degassing;
Mobile alakoso B (0.1% acetonitrile trifluoroacetic acid): gba deede 2.0ml trifluoroacetic acid, ti fomi po si 2000ml pẹlu acetonitrile, dapọ ati degassing;
Akoko (iṣẹju) A% B%
0.00 90 10
13.00 10 90
18.00 10 90
18.01 90 10
23.00 90 10
2.6 Igbaradi ti ojutu ayẹwo
Ṣe iwọn ati tu 0.1g ayẹwo pẹlu acetonitrile ati dilute si 100ml, gbọn daradara fun lilo, tabi ifọkansi kanna.Mura awọn ayẹwo meji ni afiwe.
2.7 Apeere Ipinnu
Ṣe ayẹwo ayẹwo ni ibamu si ilana iṣapẹẹrẹ wọnyi:
Diẹ ẹ sii ju abẹrẹ 1 ti ojutu òfo
Ojutu ayẹwo abẹrẹ 1 1 #
Ojutu ayẹwo abẹrẹ 1 2#
2.8 Abajade Isiro
2.8.1 Ọna isọdọtun agbegbe ti o ga julọ ni a lo lati ṣe iṣiro mimọ HPLC nipa yiyọkuro aaye òfo.
2.8.2 Itumọ ibatan ibatan ti mimọ ti awọn abẹrẹ meji ko ni tobi ju 1%
2.8.3 Ti awọn abajade ti awọn abẹrẹ mejeeji ni ibamu pẹlu awọn ibeere gbigba, a mu iwọn mimọ jẹ bi abajade ikẹhin.
3, aaye yo -- RY-1 ohun elo aaye yo
4. Pipadanu lori ọna idanwo gbigbe
4.1 Awọn irinṣẹ:
Ina thermostatic gbigbe adiro, 1/10.000 iwontunwonsi.
4.2 Ilana:
Ninu igo wiwọn alapin pẹlu iwuwo igbagbogbo ati ideri ẹnu ilẹ-gbigbẹ, ṣe iwọn giramu 1 (deede si 0.0001 giramu) ti apẹẹrẹ.Awọn ayẹwo yẹ ki o wa ni boṣeyẹ tan ni isalẹ ti igo wiwọn pẹlu sisanra ti ko si siwaju sii ju 10mm, fi sinu kan thermostatic ina gbigbẹ adiro, gbẹ ni 105 ~ 110 ℃ fun 3 wakati, ati ki o si gbe sinu awọn gbigbe yara lati dara si. yara otutu fun iwon.
Iṣiro: Isonu lori gbigbe %= (M1-M2) ÷M×100
Nibo: M1: iwuwo ayẹwo ati igo wiwọn ṣaaju gbigbe, giramu
M2: iwuwo ayẹwo ati igo wiwọn lẹhin gbigbe, ni awọn giramu
M: Iwọn ayẹwo, giramu
5. Yiyi pato
-- Yiyi pato jẹ iwọn ni ibamu pẹlu GB/T613-1988
Apeere igbaradi: 0.5000g ayẹwo ni a ṣe deede ati ki o gbe lọ si igo volumetric 50ml ti o mọ ati ti o gbẹ, 20ml DMF ti a fi kun, igo ti a fipa ati gbigbọn lati tu, ati lẹhinna ti fomi si iwọn pẹlu DMF.
Idanwo: Ṣatunṣe odo ti gyroscope ṣaaju idanwo naa, lẹhinna gbe tube idanwo pẹlu ojutu ayẹwo, gbasilẹ igun iyipo, ki o ṣe iṣiro iyipo pato ti apẹẹrẹ pẹlu agbekalẹ atẹle.
[а] D20=(r×50) ÷ (L×W)
[а] D20: Yiyi opiti pato ni 25 ℃ ti ojutu ayẹwo
r: Yiyi opiti ti a ṣe akiyesi ni 20 ℃ fun ojutu ayẹwo
50: Iwọn ti ojutu ayẹwo ti a pese silẹ (milimita)
w: Iwọn ayẹwo (g)
L: Gigun tube iyipo opitika (dm)
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Awọn aami ewu Xi - Irritant
Awọn koodu Ewu 36/37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Aabo S22 - Maṣe simi eruku.
S24/25 - Yago fun olubasọrọ pẹlu ara ati oju.
S36/37/39 - Wọ aṣọ aabo to dara, awọn ibọwọ ati aabo oju / oju.
S27 - Mu gbogbo aṣọ ti o ti doti kuro lẹsẹkẹsẹ.
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
WGK Germany 3
HS koodu 2922491990
N-Fmoc-L-Leucine (Fmoc-Leu-OH) (CAS: 35661-60-0) jẹ itọsẹ amino acid ti a le pese sile nipasẹ iṣesi ti L-Leucine ati 9-Fluorenomethoxycarbonyl Chloride.
Fmoc-amino acids, ti a lo ninu iṣelọpọ peptide, ti a lo bi agbedemeji iṣelọpọ Organic, agbedemeji elegbogi, reagent biokemika tabi reagent kemikali.
Fmoc-L-Leu-OH, jẹ itọsẹ amino acid, ti a lo ninu kemistri peptide.Didara ile Àkọsílẹ fun baraku ri to peptide kolaginni awọn wọnyi Fmoc-ilana.O tun jẹ ọkan ninu aramada PPARγ ligands ti o le mu PPARγ ṣiṣẹ ni awọn ọna oriṣiriṣi, ti o dinku iyatọ osteoclasts, ati nitorinaa jẹ awọn ibi-afẹde itọju ti o dara julọ ni àtọgbẹ ju awọn oogun antidiabetic ibile lọ.
Igbaradi 1.05g (0.008 mol) L-Leucine ri to ni tituka ni 10% iṣuu soda carbonate ojutu, rú lati ni kikun tu glycine ri to, ati 9-fluorene methoxycarbonyl kiloraidi (2.10g, 0.008 mol) ojutu ni tituka ni toluene (2 ~ 205 milimita) ti wa ni afikun dropwise ni 20 ~ 30 ℃, ju afikun fun 30 ~ 60 iṣẹju, pari awọn dropwise afikun, aruwo ni 20 ~ 30℃ fun 1 ~ 8 wakati, fi 30-200 milimita ti omi lati dilute, ati ki o jade pẹlu n-butyl acetate (80 milimita) lati yọkuro 9-fluorene methoxycarbonyl chloride ti o pọju, Ipele olomi ti a gba ti wa ni acidified pẹlu ogidi hydrochloric acid si PH = 0.5 ~ 3.5, ati lẹhinna fa jade pẹlu n-butyl acetate (80 milimita), ati ipele epo ti o gba jẹ ti a fọ pẹlu omi lati yọ hydrochloric acid kuro, ipele epo ti wa ni idojukọ lati yọ iyọkuro n-butyl acetate kuro, awọn kirisita funfun ti ṣaju, ti a ti yan ati ti o gbẹ lati gba 2.46g ti Nα-9-fluorene methoxycarbonyl-L-leucine, pẹlu ikore ti 87.0 %.
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