Fondaparinux soda CAS 114870-03-0 API
Ipese pẹlu Iwa mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Fondaparinux Sodium
CAS: 114870-03-0
An Antithrombotic Anticoagulant, Factor Xa inhibitor
API Didara Giga, Iṣelọpọ Iṣowo
Orukọ Kemikali | Fondaparinux iṣuu soda |
Nọmba CAS | 114870-03-0 |
NỌMBA CAT | RF-API84 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C31H43N3O49S8.10NA |
Òṣuwọn Molikula | 1728.08 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun to Pa-White Powder |
Aseyori / Analysis Ọna | 95.0% ~ 103.0% (lori ipilẹ ti o gbẹ) |
Solubility | Soluble Larọwọto ninu Omi, 2.0M Sodium Chloride ati 0.5M Sodium Hydroxide ati Insoluble ni Ethanol |
Idanimọ 13C-NMR | Awọn atunṣe fun Fondaparinux Sodium yẹ ki o ṣe akiyesi ni 58.2, 29.5, 60.5, 60.8, 68.9, 69.2, 69.6, 98.9, 100.4, 101.1, 102.4, 103.9, 176.7.7Awọn iyipada Kemikali ti awọn ifihan agbara wọnyi ko ni iyatọ nipasẹ diẹ ẹ sii ju ± 0.3ppm awọn ifihan agbara miiran ti awọn giga iyipada ati awọn iyipada kemikali, ti a ṣe si Fondaparinux Sodium, boya ri laarin 58.0 ~ 80.5 ppm ati 98.7 ~ 104.5ppm |
HPLC idanimọ | Akoko idaduro ti oke pataki ti ojutu ayẹwo ni ibamu si ti ojutu boṣewa |
AAS idanimọ | Iṣuu soda yẹ ki o ni gbigba abuda ni 330.2nm labẹ ipinnu iṣuu soda |
pH | 6.0 ~ 8.0 |
Sodium (Na) | 11.5% ~ 15.0% (Iṣiro lori anhydrous ati awọn olomi-ọfẹ) |
Sulfate ọfẹ | ≤0.30% |
Kloride to ku | ≤1.00% |
Awọn nkan ti o jọmọ | |
Aimọ́ A | ≤0.80% |
Aimọ́ B | ≤0.60% |
Nikan Miiran Aimọ | ≤0.30% |
Lapapọ Awọn Aimọ | ≤2.00% |
Awọn ohun elo ti o ku | |
kẹmika kẹmika | ≤3000ppm |
Ethanol | ≤5000ppm |
Ethyl acetate | ≤5000ppm |
DMF | ≤880ppm |
Methylbenzene | ≤890ppm |
Pyridine | ≤50ppm |
Akoonu Omi (KF) | ≤15.0% |
Awọn endotoxins kokoro arun | ≤3.3EU/mg |
Makirobia Ifilelẹ | Nọmba apapọ awọn microorganisms ≤100cfu/g |
Igbeyewo Standard | Standard Enterprise;United States Pharmacopoeia (USP) Standard |
Lilo | API, An Antithrombotic Anticoagulant, Factor Xa inhibitor |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
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Fondaparinux Sodium (CAS 114870-03-0) jẹ akọkọ ti kilasi tuntun ti antithrombotic anticoagulant kemikali ti o ni ibatan si awọn heparins iwuwo molikula kekere (LMWH).Fondaparinux soda jẹ ifosiwewe Xa inhibitor lati ṣe agbekalẹ aaye isọdọmọ giga fun ifosiwewe antithrombin III (ATIII) anticoagulant.Fondaparinux iṣuu soda abuda ni aaye yii ṣe agbara ipa inhibitory adayeba ti ATIII lodi si ifosiwewe Xa nipasẹ ipin kan ti o to 300, eyiti o yorisi idinamọ ti iran thrombin.O ti wa ni tita nipasẹ GlaxoSmithKline.Ẹya jeneriki ti o dagbasoke nipasẹ Alchemia ti wa ni tita laarin AMẸRIKA nipasẹ Awọn ile-iṣẹ Dokita Reddy.Fondaparinux soda ni a kọkọ ṣe afihan ni AMẸRIKA fun idena ti iṣọn-ẹjẹ iṣọn jinlẹ eyiti o le ja si iṣọn-ẹjẹ ẹdọforo lẹhin iṣẹ abẹ orthopedic pataki.Molikula sintetiki patapata yii jẹ ẹda ti ọkọọkan heparin pentasaccharide, ajẹkù ti o kuru ju ni anfani lati ṣe itusilẹ antithrombin lllmediated inhibition ti ifosiwewe Xa nitorinaa ṣe idiwọ iran thrombin laisi iṣe antithrombin.
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