Ganciclovir CAS 82410-32-0 API BW 759 GCV Antiviral CMV Inhibitor Didara Giga
Ipese Olupese pẹlu Iwa-mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Ganciclovir
CAS: 82410-32-0
Aṣoju Antiviral fun Itọju ti Cytomegalovirus (CMV) Ikolu
API Didara Giga, Iṣelọpọ Iṣowo
Orukọ Kemikali | Ganciclovir |
Awọn itumọ ọrọ sisọ | GCV;BW 759;9-[[2-Hydroxy-1- (hydroxymethyl)ethoxy]methyl] guanine;2-Amino-9- (1,3-dihydroxypropan-2-yloxymethyl) -3H-purin-6-ọkan;2'-Nra-2'-Deoxyguanosine |
Nọmba CAS | 82410-32-0 |
NỌMBA CAT | RF-API82 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C9H13N5O4 |
Òṣuwọn Molikula | 255.23 |
Ojuami Iyo | 250 ℃ |
Ibi ipamọ otutu | 2-8℃ |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun lati Pa-White Crystalline Powder |
Solubility | Pupọ Tiotuka pupọ ninu Omi |
Idanimọ | Gbigbe Ultraviolet, Gbigba infurarẹẹdi |
Pipadanu lori Gbigbe | ≤6.0% |
Aloku lori Iginisonu | ≤0.10% |
Awọn nkan ti o jọmọ | Agbo ti o jọmọ Ganciclovir A ≤0.50% |
Ifilelẹ ti Guanine | ≤0.50% |
Awọn ojutu ti o ku (GC) | Ethanol ≤5000ppm |
Awọn irin Heavy | ≤10ppm |
Olusọdipúpọ gbigba | 516-548 ni 252nm |
Awọn endotoxins kokoro arun | ≤0.84EU/mg |
Ayẹwo | 98.0% ~ 102.0% (Titration) |
Igbeyewo Standard | Standard Enterprise;United States Pharmacopoeia (USP) Standard |
Lilo | API, CMV Inhibitor |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Ganciclovir (CAS 82410-32-0) jẹ ti awọn oogun antiviral nucleoside, jẹ iru awọn itọsẹ guanosine.Ganciclovir jẹ aṣoju antiviral ti nṣiṣe lọwọ obi ti a tọka fun oju- tabi awọn akoran cytomegalovirus (CMV) eewu-aye ni awọn alaisan ajẹsara.O ni awọn ipa-ọna ti o gbooro, awọn ipa inhibitory giga-daradara lori ọlọjẹ Herpes ati pe o jẹ oogun yiyan akọkọ fun itọju ikolu cytomegalovirus pẹlu ipa to lagbara lori ọlọjẹ jedojedo B ati adenovirus pẹlu.O jẹ homologue ti acyclovir (ACV) pẹlu ipa antiviral ti o jọra bi, ṣugbọn lagbara ju aciclovir, nini paapaa awọn ipa inhibitory ti o lagbara lori cytomegalovirus ti o ni nkan ṣe pẹlu awọn alaisan AIDS.O jẹ ile-iwosan fun itọju ti ipele ifisi ati ipele itọju lori awọn alaisan ti ko ni ajẹsara (pẹlu awọn alaisan Eedi) pẹlu retinitis cytomegalovirus nigbakanna.O tun le ṣee lo fun idena ti arun cytomegalovirus fun awọn alaisan ti o ngba gbigbe ara tabi awọn alaisan Eedi pẹlu awọn abajade rere ni idanwo serology cytomegalovirus.
Ganciclovir (CAS 82410-32-0) jẹ imudara pupọ, majele-kekere ati oludena ọlọjẹ yiyan yiyan ti o dagbasoke nipasẹ Ile-iṣẹ Syntex (United States).O jẹ oogun akọkọ ti FDA AMẸRIKA ti fọwọsi fun itọju ikolu cytomegalovirus (CMV).Syntex ti funni ni ẹtọ iyasọtọ ti iṣelọpọ.Ni Oṣu kẹfa ọdun 1988, tabulẹti yii ti fọwọsi fun igba akọkọ lati ṣe atokọ ni UK, atẹle nipa ifọwọsi ni itẹlera nipasẹ Faranse, Amẹrika, Japan, ati Iwọ-oorun Germany, Italy ati Canada ati awọn orilẹ-ede miiran.Titi di opin Oṣu Karun ọdun 1999, o ti fọwọsi ni diẹ sii ju awọn orilẹ-ede 70 ati awọn agbegbe fun idena ti awọn alaisan ajẹsara ati ikolu cytomegalovirus ti awọn alaisan ti gbigbe ara eniyan.Ni 2002, awọn tabulẹti Ganciclovir ti gba ifọwọsi ti FDA, di wa ni bayi.