Gemcitabine CAS 95058-81-4 Assay 98.0 ~ 102.0%

Apejuwe kukuru:

Orukọ Kemikali: Gemcitabine

CAS: 95058-81-4

Ayẹwo: 98.0 ~ 102.0%

Funfun tabi Fere Funfun Crystalline Powder, Odorless

Olubasọrọ: Dokita Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com


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95058-81-4 - Apejuwe:

Shanghai Ruifu Kemikali Co., Ltd jẹ olupese ti Gemcitabine (CAS: 95058-81-4) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Gemcitabine,Please contact: alvin@ruifuchem.com

95058-81-4 - Kemikali Properties:

Orukọ Kemikali Gemcitabine
Awọn itumọ ọrọ sisọ 2'-Deoxy-2',2'-Difluorocytidine;4-Amino-1-[3,3-Difluoro-4-Hydroxy-5- (Hydroxymethyl) oxolan-2-yl] pyrimidin-2-ọkan;dFDC;Gemzar (Lilly);LY-188011;dFdCyd;DDFC;2',2'-Difluoro-2'-deoxycytidine;2',2'-Difluorodeoxycytidine;Folfugem;GemLip;Gemcel;Gamcitabine
Iṣura Ipo Ni Iṣura, Agbara iṣelọpọ 5 Toonu
Nọmba CAS 95058-81-4
CAS ti o ni ibatan 122111-03-9
Fọọmu Molecular C9H11F2N3O4
Òṣuwọn Molikula 263,20 g / mol
Ojuami Iyo 217.0 si 222.0 ℃
iwuwo 1,84 ± 0,10 g / cm3
Ni imọlara Ooru kókó
Omi Solubility Ailesolusan ninu Omi
COA & MSDS Wa
Ipilẹṣẹ Shanghai, China
Brand Ruifu Kemikali

95058-81-4 - Awọn pato:

Awọn nkan Awọn pato Esi
Ifarahan Funfun tabi Fere Funfun Crystalline Powder, Odorless Ibamu
Cytosine ≤0.10% 0.002%
α-Isomer ≤0.10% 0.01%
Olukuluku Aimọ ≤0.10% 0.03%
Lapapọ Awọn Aimọ ≤1.00% 0.10%
Omi nipa Karl Fischer ≤1.00% 0.67%
Yiyi pato + 68,0 ° ~ + 74,0 ° +70.5°
Awọn irin Heavy ≤10ppm <10ppm
Aloku lori Iginisonu ≤0.10% 0.03%
Ayẹwo (Nipasẹ HPLC) 98.0% ~ 102.0% 99.9%
Infurarẹẹdi julọ.Oniranran Ni ibamu pẹlu Eto Ibamu
1H NMR julọ.Oniranran Ni ibamu pẹlu Eto Ibamu
Ipari Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun

Package/Ipamọ/Gbigbe:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati fipamọ sinu itura, gbigbẹ ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Yago fun ifihan si orun taara, ọrinrin ati ooru ti o pọju.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

Awọn anfani:

Agbara to to: Awọn ohun elo to ati awọn onimọ-ẹrọ

Iṣẹ Ọjọgbọn: Iṣẹ rira iduro kan

OEM Package: Aṣa package ati aami wa

Ifijiṣẹ Yara: Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta

Ipese Idurosinsin: Ṣetọju ọja iṣura ti o tọ

Atilẹyin imọ-ẹrọ: Ojutu imọ-ẹrọ wa

Iṣẹ Iṣọkan Aṣa: Larin lati giramu si kilos

Didara to gaju: Ṣeto eto idaniloju didara pipe

FAQ:

Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.

Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.

Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.

DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl

Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.

Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.

MOQ?Ko si MOQ.Ibere ​​kekere jẹ itẹwọgba.

Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.

Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.

Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.

Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.

Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.

95058-81-4 - Ewu ati Aabo:

Awọn koodu ewu R21 - ipalara ni olubasọrọ pẹlu awọ ara
R36 / 38 - Irritating si oju ati awọ ara.
R46 - Le fa hertable jiini bibajẹ
R62 - Owun to le ewu ti bajẹ irọyin
R63 - Owun to le ewu ipalara si awọn unborn ọmọ
Apejuwe Aabo S25 - Yago fun olubasọrọ pẹlu awọn oju.
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S36/37 - Wọ aṣọ aabo ati awọn ibọwọ to dara.
S53 - Yago fun ifihan - gba awọn ilana pataki ṣaaju lilo.
HS koodu 2934999091
Majele LD10 iv ninu awọn eku: 200 mg/m2 (Abbruzzese)

95058-81-4 - Ohun elo:

Gemcitabine (CAS: 95058-81-4) jẹ oogun chemotherapy ti a lo lati tọju nọmba awọn oriṣi ti akàn.Eyi pẹlu jẹjẹrẹ igbaya, akàn ẹdọfóró sẹẹli ti kii ṣe kekere, akàn pancreatic, akàn àpòòtọ, ati akàn biliary tract.Gemcitabine ti wa ni iwadi fun lilo ninu akàn esophageal, ati pe a lo ni idanwo ni awọn lymphomas ati awọn oriṣiriṣi tumo miiran.Gemcitabine ni a nṣakoso nipasẹ ọna iṣọn-ẹjẹ, niwọn igba ti o jẹ iṣelọpọ pupọ nipasẹ ọna ikun ati inu.
Gemcitabine jẹ afọwọṣe nucleotide, eyiti o jẹ ti kilasi anti-metabolic ti awọn oogun anticancer.O ṣe pataki lori ipele iṣelọpọ DNA, iyẹn ni, apakan S.Labẹ awọn ipo kan, o le ṣe idiwọ ipele G1 lati ni ilọsiwaju si ipele S.O ni awọn abuda ti irisi anticancer jakejado, ẹrọ iṣe alailẹgbẹ ti iṣe, majele kekere, ko si atako agbelebu si awọn oogun chemotherapy miiran ati pe ko si ipo ti majele.Iwe kemikali, gemcitabine, ti fọwọsi ni bayi fun lilo ni diẹ sii ju awọn orilẹ-ede 90, ti o jẹ ki o jẹ itọju laini akọkọ fun akàn ẹdọfóró sẹẹli ti kii ṣe kekere ati “iwọn goolu” fun akàn pancreatic.
Ni 1999, CFDA fọwọsi gemcitabine fun itọju ti agbegbe to ti ni ilọsiwaju tabi NSCLC metastatic, ilọsiwaju agbegbe tabi akàn pancreatic metastatic;Ni 2010, CChemicalbookFDA fọwọsi gemcitabine ni apapo pẹlu paclitaxel fun itọju ti a ko le ṣe atunṣe, loorekoore ti agbegbe tabi akàn igbaya metastatic ti o ti nwaye lẹhin adjuvant/neoadjuvant chemotherapy.
Gemcitabine jẹ antimetabolite ti o gbooro ati afọwọṣe deoxycytidine pẹlu iṣẹ antineoplastic.Lẹhin iṣakoso, gemcitabine ti yipada si awọn metabolites ti nṣiṣe lọwọ difluorodeoxycytidine diphosphate (dFdCDP) ati difluorodeoxycytidine triphosphate (dFdCTP) nipasẹ deoxycytidine kinase.dFdCTP ti njijadu pẹlu deoxycytidine triphosphate (dCTP) ati pe a dapọ si DNA.Eyi ṣe titiipa DNA polymerase nitorinaa abajade ni ifopinsi boju-boju lakoko ẹda DNA.Ni ida keji, dFdCDP n ṣe idiwọ ribonucleotide reductase, nitorina o dinku adagun-odo deoxynucleotide ti o wa fun iṣelọpọ DNA.Idinku ninu ifọkansi intracellular ti dCTP n mu iṣiṣẹpọ dFdCTP sinu DNA.

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