Hisitamine Dihydrochloride CAS 56-92-8 Assay 98.5 ~ 101.0% (Titration) Factory
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ati olupese ti Histamine Dihydrochloride (CAS: 56-92-8) pẹlu didara to gaju.Ogidi nkanL-Histidine (H-His-OH) (CAS: 71-00-1)A le pese ifijiṣẹ agbaye, kekere ati titobi pupọ ti o wa.Ti o ba nifẹ si histamine Dihydrochloride,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Hisitamine Dihydrochloride |
| Awọn itumọ ọrọ sisọ | histamini 2HCl;Hisitamine DiHCl;2- (4-Imidazolyl) ethylamine Dihydrochloride;2- (1H-Imidazol-4-yl) ethylamine Dihydrochloride;2- (1H-Imidazol-4-yl) ethylamine Dihydrochloride;1H-Imidazole-4-ethanamine Dihydrochloride;Ceplene;Peremin |
| Iṣura Ipo | Ninu Iṣura, Agbara iṣelọpọ 20 Toonu fun oṣu kan |
| Nọmba CAS | 56-92-8 |
| Fọọmu Molecular | C5H9N3·2HCl |
| Òṣuwọn Molikula | 184.06 |
| Ojuami Iyo | 247.0 ~ 249.0 ℃ (tan.) |
| iwuwo | 1.14 |
| Ni imọlara | Hygroscopic |
| Omi Solubility | Tiotuka Patapata ninu Omi, O fẹrẹ jẹ akoyawo |
| Solubility | Tiotuka pupọ ni kẹmika, Soluble ni Ethanol, Insoluble ni Eteri |
| Ibi ipamọ otutu. | Ididi ni Gbẹ, Itaja ni Yara otutu |
| COA & MSDS | Wa |
| Brand | Ruifu Kemikali |
| Awọn koodu ewu | Xn,Xi | RTECS | MS1575000 |
| Awọn Gbólóhùn Ewu | 36/37/38-42/43-42-22 | F | 1-8-9 |
| Awọn Gbólóhùn Aabo | 22-26-36/37/39-45-37-36/37 | TSCA | Bẹẹni |
| RIDADR | 3335 | Kíláàsì ewu | Irritant |
| WGK Germany | 2 | HS koodu | 2933990099 |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Awọn kirisita funfun tabi Crystalline Powder | Ni ibamu |
| Idanimọ | Infurarẹẹdi Absorption julọ.Oniranran | Ni ibamu |
| Ifarahan ti Solusan | Ko o | Kọja |
| Histidine (TLC) | Ko ṣe Wari | Ni ibamu |
| Sulfate (SO4) | ≤0.020% | <0.020% |
| Irin (Fe) | ≤10ppm | <10ppm |
| Awọn Irin Eru (Pb) | ≤10ppm | <10ppm |
| Arsenic (As2O3) | ≤10ppm | <10ppm |
| Pipadanu lori Gbigbe | ≤0.50% | 0.24% |
| Sulfated Ash | ≤0.20% | 0.06% |
| Ayẹwo | 98.5 si 101.0% (nipasẹ Titration) | 99.36% |
| Iye pH | 2.85 si 3.60 (10% aq. Solusan) | 3.16 |
| Ipari | Ni ibamu pẹlu Standard of AJI97, EP9.0 | |
| Awọn Lilo akọkọ | Amino acids;Awọn afikun Ounjẹ;elegbogi Intermediates | |
Awọn ohun elo aise ati awọn ojutu ti o kan ninu Ilana Asopọmọra
Awọn ohun elo aise:
L-Histidine (H-Re-OH) CAS 71-00-1
Acetofenone CAS 98-86-2
Hydrochloric Acid CAS 7647-01-0
Awọn ojutu
Diethylene Glycol CAS 111-46-6
Ẹmu CAS 64-17-5
Isopropyl Ọtí CAS 67-63-0
Omi
Histamine Dihydrochloride (CAS: 56-92-8) EP9.0 Iwọn didunⅡ Ọna Idanwo
ITUMO
Histamine dihydrochloride ni ko kere ju 98.5 ogorun ati pe ko ju deede ti 101.0 ogorun ti 2- (1H-imidazol-4-yl)ethan-1-amine dihydrochloride, ṣe iṣiro pẹlu itọkasi si nkan ti o gbẹ.
ÀWỌN ÀWỌN ÀWỌN ADÁJỌ́
A funfun tabi fere funfun, okuta lulú tabi awọn kirisita ti ko ni awọ, hygroscopic, tiotuka pupọ ninu omi, tiotuka ninu oti.
Ìdámọ̀
Idanimọ akọkọ: A, D.
Idanimọ keji: B, C, D
A. Ṣe ayẹwo nipasẹ spectrophotometry gbigba infurarẹẹdi (2.2.24), ni ifiwera pẹlu spekitiriumu ti a gba pẹlu histamini dihydrochloride CRS.Ṣayẹwo bi awọn disiki ti a pese sile nipa lilo 1 miligiramu ti nkan na.
B. Ṣayẹwo awọn chromatograms ti a gba ninu idanwo fun histidine.Aami akọkọ ninu chromatogram ti a gba pẹlu ojutu idanwo (b) jẹ iru ni ipo, awọ ati iwọn si aaye akọkọ ninu chromatogram ti a gba pẹlu ojutu itọkasi (a).
C. Tu 0.1 g ni 7 milimita ti omi R ki o si fi 3 milimita ti 200 g/L ojutu sodium hydroxide R. Tu 50mg ti sulfanilic acid R ni adalu 0.1 mL ti hydrochloric acid R ati 10 mL ti omi R ati fi 0.1 milimita ti iṣuu soda nitrite ojutu R. Fi ojutu keji si akọkọ ati ki o dapọ.Awọ pupa ni a ṣe.
D. O funni ni esi (a) ti awọn kiloraidi (2.3.1).
AWON idanwo
Solusan S. Tu 0.5g ninu omi ti ko ni erogba oloro R ti a pese sile lati inu omi ti a ti sọ distilled R ati dilute si 10 milimita pẹlu epo kanna.
Ifarahan ti ojutu.Solusan S jẹ kedere (2.2.1) ati pe ko ni awọ diẹ sii ju itọka itọkasi Y7 (2.2.2, Ọna II).
pH (2.2.3).pH ti ojutu S jẹ 2.85 si 3.60.
Histidine.Ṣayẹwo nipasẹ kiromatografi tinrin-Layer (2.2.27), ni lilo TLC silica gel plate R.
Idanwo ojutu (a).Tu 0.5g ti nkan na lati ṣe ayẹwo ni omi R ati dilute si 10 milimita pẹlu epo kanna.
Idanwo ojutu (b).Di 2 milimita ti ojutu idanwo (a) si 10 milimita pẹlu omi R.
Ojutu itọkasi (a).Tu 0.1 g histamini dihydrochloride CRS sinu omi R ati dilute si 10 milimita pẹlu epo kanna.
Ojutu itọkasi (b).Tu 50 miligiramu ti histidine monohydrochloride R inu omi R ati dilute si 100 milimita pẹlu epo kanna.
Ojutu itọkasi (c).Illa 1 milimita ti ojutu idanwo (a) ati 1 milimita ti ojutu itọkasi (b).
Kan si awo 1 μL ti ojutu idanwo (a), 1 μL ti ojutu idanwo (b), 1 μL ti ojutu itọkasi (a), 1 μL ti ojutu itọkasi (b) ati 2 μL ti ojutu itọkasi (c).Dagbasoke lori ọna ti 15cm nipa lilo adalu 5volumes ti amonia R ti o ni idojukọ, awọn iwọn 20 ti omi R ati awọn ipele 75 ti acetonitrile R. Gbẹ awo naa ni lọwọlọwọ ti afẹfẹ.Tun idagbasoke naa ṣe ni itọsọna kanna, gbẹ awo naa ni curren ti afẹfẹ ati fun sokiri pẹlu ninhydrin ojutu R1.Mu awo naa ni 110 ° C fun iṣẹju 10.Eyikeyi iranran ti o baamu si histidine ninu chromatogram ti a gba pẹlu ojutu idanwo (a) ko ni iwọn diẹ sii ju aaye ninu chromatogram ti o gba pẹlu ojutu itọkasi (b) (1 fun ogorun).Idanwo naa ko wulo ayafi ti chromatogram ti o gba pẹlu ojutu itọkasi (c) fihan awọn aaye 2 ti o yapa ni kedere.
Sulfates (2.4.13).3mL ti ojutu S ti fomi si 15 milimita pẹlu omi distilled R ni ibamu pẹlu idanwo opin fun awọn sulfates (0.1 ogorun).
Isonu lori gbigbe (2.2.32).Ko ju 0.5 ogorun, pinnu lori 0.20 g nipasẹ gbigbe ni adiro ni 105 °C.
eeru sulfated (2.4.14).Ko ju 0.1 ogorun, pinnu lori 0,5 g.
ASAY
Tu 0.080 g ninu adalu 5.0 milimita ti 0.01 M hydrochloric acid ati 50 milimita ti oti R. Ṣe titration potentiometric (2.2.20), ni lilo0.1 M sodium hydroxide.Ka iwọn didun ti a ṣafikun laarin awọn aaye akọkọ ati awọn aaye kẹta ti inflexion.
1mL ti 0.1 M sodium hydroxideis deede si 9.203 mg ti C5H11Cl2N3.
Ìpamọ́
Fipamọ sinu apo eiyan afẹfẹ, aabo lati ina.
Package: Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti edidi ni itura, gbigbẹ ati ile-itaja ti afẹfẹ kuro ni awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
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DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
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MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
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Ohun elo ti histamini Dihydrochloride (CAS: 56-92-8)
1. Histamine Dihydrochloride ti han lati mu ṣiṣẹ nitric oxide synthetase ati ki o dinku tabi dena iran ti awọn ẹya atẹgun ti o ni ifaseyin (ROS).Idinku ti ROS nipasẹ Histamine Dihydrochloride ngbanilaaye imuṣiṣẹ ti awọn sẹẹli T ati awọn sẹẹli NK nipasẹ IL-2.Ninu awoṣe eku, histamini dihydrochloride ti tẹ ROS ti ipilẹṣẹ nipasẹ awọn sẹẹli Kupffer nipasẹ olugba histamini H2.O jẹ vasodilator ti o lagbara ati agonist olugba histamini endogenous.
2. Histamine Dihydrochloride (orukọ iṣowo Ceplene) jẹ iyọ ti histamini ti a lo bi oogun fun idena ti ifasẹyin ni awọn alaisan ti o ni ayẹwo pẹlu aisan lukimia myeloid nla (AML).
O jẹ eroja ti nṣiṣe lọwọ FDA ti a fọwọsi fun lilo analgesic ti agbegbe ati pe o wa ni iru awọn ọja bii Ipara Ala Ọstrelia, eyiti a lo fun iderun igba diẹ ti awọn irora kekere ati awọn irora ti awọn iṣan ati awọn isẹpo ti o ni nkan ṣe pẹlu arthritis, ẹhin ti o rọrun, ọgbẹ, sprains, ati awọn igara.
3. Histamine Dihydrochloride ti wa ni lilo fun idariji idaduro ati idena ti ifasẹyin ni awọn alaisan agbalagba ti o ni aisan lukimia mieloid nla (AML) ti o tẹle itọju ailera idariji akọkọ.Oogun naa dinku iṣelọpọ awọn ẹgbẹ atẹgun nipasẹ awọn autophagocytes, ṣe idiwọ nicotinamide adenine dichemicalbo fosifeti oxidase ati idilọwọ interleukin-2 lati mu awọn sẹẹli NK ṣiṣẹ ati awọn sẹẹli T.Abẹrẹ histamini Dihydrochloride ni a fọwọsi lori ipilẹ pe idariji pipe rẹ ni apapọ pẹlu interleukin-2 dinku ifasẹyin ni pataki ni awọn alaisan AML.
