N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS 152460-10-1 Imatinib Mesylate Intermediate High Purity
Ipese Iṣowo Imatinib Mesylate ati Awọn agbedemeji ti o jọmọ:
Imatinib Mesylate CAS: 220127-57-1
N- (2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS: 106261-49-8
| Orukọ Kemikali | N- (5-Amino-2-methylphenyl)-4- (3-pyridyl) -2-pyrimidinea. |
| Awọn itumọ ọrọ sisọ | Imatinib Mesylate Intermediate;2- (5-Amino-2-methylanilino) -4- (3-pyridyl) pyrimidine |
| Nọmba CAS | 152460-10-1 |
| NỌMBA CAT | RF-PI230 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C16H15N5 |
| Òṣuwọn Molikula | 277.32 |
| Ojuami Iyo | 133.0-135.0 ℃ |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Light Orange to Yellow Powder to Crystal |
| Mimọ / Analysis Ọna | ≥98.0% |
| Pipadanu lori Gbigbe | ≤0.50% |
| Aloku lori iginisonu | ≤0.50% |
| Lapapọ Awọn Aimọ | ≤2.0% |
| O pọju Nikan Aimọ | ≤1.0% |
| Awọn Irin Eru | ≤20ppm |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Laarin Imatinib Mesylate (CAS: 220127-57-1) |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ati olupese ti N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) pẹlu didara to gaju. .
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea (CAS: 152460-10-1) jẹ agbedemeji deede ni iṣelọpọ ti Imatinib Mesylate (CAS: 220127-57-1). ) API.
Imatinib mesylate jẹ moleku kekere kan ti o dẹkun c-Abl protein-tyrosine kinase, kinase pataki pataki fun afikun ti aisan lukimia myelogenous onibaje (CML).Iṣẹlẹ iyipada laarin awọn krómósómù 9 ati 22 ṣe ipilẹṣẹ chromosome Philadelphia, eyiti o ṣe agbejade amuaradagba idapọ Bcr-Ab pẹlu iṣẹ ṣiṣe aberrant kinase ti o ṣe agbega isọdi sẹẹli ni iyara.Imatinib mesylate ṣe asopọ kinase pataki yii, o dẹkun idagba ti o ni ibatan CML.Imatinib mesylate ti ṣe afihan siwaju lati ṣe idiwọ PDGFR ati awọn kinases tyrosine ti o ni nkan ṣe pẹlu c-Kit.Awọn agbekalẹ ti o ni Imatinib mesylate ni a ti lo ninu itọju awọn oriṣiriṣi awọn aarun.
Imatinib mesylate jẹ inhibitor tyrosine kinase.Ni pato pataki fun BCR-ABL, enzymu ti o ni nkan ṣe pẹlu aisan lukimia myelogenous onibaje (CML) ati awọn iru kan ti aisan lukimia lymphoblastic nla (GBOGBO).O jẹ onidalẹkun v-Abl tyrosine kinase ti o lagbara ati yiyan (IC50 = 38 nM).Tun ṣe idiwọ PDGFR ati c-kit.Afihan yiyan fun v-Abl lori nronu kan ti miiran tyrosine ati serine/threonine amuaradagba kinases.Yiyan ṣe idiwọ idagbasoke PDGF ti o ni itara ti awọn sẹẹli PB-3 ti o yipada v-abl ati awọn sẹẹli BALB/c 3T3 ti o yipada ni vitro.Ṣe afihan awọn ipa antitumor ninu awọn eku ti o ni AMuLV tabi awọn sẹẹli BABL/c 3T3 v-sis.Ṣe idiwọ ẹda SARS-CoV ati MERS-CoV in vitro (awọn iye EC50 jẹ 9.823 ati 17.689 μM, lẹsẹsẹ).
![4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)