Imatinib Mesylate CAS 220127-57-1 Assay 98.0%~102.0% Ph+CML API Factory High Quality
Ipese Iṣowo Imatinib Mesylate ati Awọn agbedemeji ti o jọmọ:
Imatinib Mesylate CAS: 220127-57-1
N- (2-Methyl-5-nitrophenyl)-4- (pyridin-3-yl) pyrimidin-2-amine CAS: 152460-09-8
N- (5-Amino-2-methylphenyl) -4- (3-pyridyl) -2-pyrimidinea CAS: 152460-10-1
4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS: 106261-49-8
| Orukọ Kemikali | Imatinib Mesylate (fọọmu alpha) |
| Awọn itumọ ọrọ sisọ | Imatinib Methanesulfonate;STI571 Mesylate;CGP-57148B |
| Nọmba CAS | 220127-57-1 |
| NỌMBA CAT | RF-API19 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C30H35N7O4S |
| Òṣuwọn Molikula | 589.71 |
| Sowo Ipò | Labẹ Ibaramu otutu |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun lati Pa-White Crystalline Powder |
| Solubility | Rọrun lati tu ninu omi |
| HPLC Idanimọ | Ayẹwo julọ.Oniranran akoko idaduro tente oke ni ibamu pẹlu iyẹn |
| IR Idanimọ | Imudani gbigba infurarẹẹdi ti apẹẹrẹ ni ibamu pẹlu apẹẹrẹ itọkasi |
| Ojuami Iyo | 214.0 ~ 222.0 ℃ |
| Pipadanu lori Gbigbe | ≤0.50% |
| Aloku lori Iginisonu | ≤0.10% |
| Awọn irin Heavy | ≤20ppm |
| Awọn nkan ti o jọmọ | (1) Aimọ G: NMT 0.3% |
| (2) Aimọ́ B: NMT 0.3% | |
| (3) Aimọ́ C: NMT 0.3% | |
| (4) Aimọ D: NMT 0.3% | |
| (5) Aimọ A: NMT 0.3% | |
| (6) Aimọ́ H: NMT 0.3% | |
| (7) Aimọ F: NMT 0.3% | |
| (8) Aimọ E: NMT 0.3% | |
| (9) Aimọ ẹyọkan ti o tobi julọ: NMT0.1% | |
| Awọn ohun elo ti o ku | (1) Ethyl Acetate: NMT 5000ppm |
| (2) kẹmika: NMT3000ppm | |
| (3) Dichloromethane: NMT 600ppm | |
| (4) Ethanol: NMT 5000ppm | |
| (5) Toluene: NMT 890ppm | |
| (6) Dimethyl Sulfoxide: NMT5000ppm | |
| HPLC Ayẹwo | 98.0% ~ 102.0% (C30H35N7SO4 Iṣiro lori ipilẹ Anhydrous) |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API;Ph+CML |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Imatinib Mesylate (CAS 220127-57-1) jẹ moleku kekere ti o dẹkun c-Abl protein-tyrosine kinase, kinase pataki pataki fun afikun ti aisan lukimia myelogenous onibaje (CML).Ni pato pataki fun BCR-ABL, enzymu ti o ni nkan ṣe pẹlu aisan lukimia myelogenous onibaje (CML) ati awọn iru kan ti aisan lukimia lymphoblastic nla (GBOGBO).O jẹ onidalẹkun v-Abl tyrosine kinase ti o lagbara ati yiyan (IC50 = 38 nM).Iṣẹlẹ iyipada laarin awọn krómósómù 9 ati 22 ṣe ipilẹṣẹ chromosome Philadelphia, eyiti o ṣe agbejade amuaradagba idapọ Bcr-Ab pẹlu iṣẹ ṣiṣe aberrant kinase ti o ṣe agbega isọdi sẹẹli ni iyara.Imatinib mesylate ṣe asopọ kinase pataki yii, o dẹkun idagba ti o ni ibatan CML.Imatinib mesylate ti ṣafihan siwaju lati ṣe idiwọ PDGFR ati awọn kinases tyrosine ti o ni nkan ṣe pẹlu c-Kit.
![4-[(4-Methylpiperazin-1-yl)methyl] benzoic acid dihydrochloride CAS 106261-49-8 Imatinib Mesylate Intermediate High Purity](https://www.ruifuchemical.com/uploads/d1fa2a19-300x300.jpg)