Irinotecan Hydrochloride CAS 100286-90-6 Mimọ ≥99.0% (HPLC) API USP Standard High Purity
Ipese Olupese Irinotecan ati Awọn agbedemeji ti o jọmọ:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Orukọ Kemikali | Irinotecan Hydrochloride |
| Awọn itumọ ọrọ sisọ | Camptothecin II;CPT-II |
| Nọmba CAS | 100286-90-6 |
| NỌMBA CAT | RF-API50 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C33H39ClN4O6 |
| Òṣuwọn Molikula | 623.15 |
| Ojuami Iyo | 250-256 ℃ (oṣu kejila) |
| Awọn ipo ipamọ | Labẹ Ibaramu otutu |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Pa-White Powder |
| Solubility | Tiotuka ninu omi ati kẹmika, die-die tiotuka ni chloroform, ethanol |
| Idanimọ IR | Iwọn gbigba infurarẹẹdi ti apẹẹrẹ idanwo yẹ ki o ni ibamu pẹlu ti boṣewa itọkasi |
| HPLC idanimọ | Akoko idaduro ti tente oke pataki ti ojutu ayẹwo yẹ ki o baamu ti boṣewa itọkasi. |
| Idanimọ | Pade awọn ibeere ti awọn idanwo fun esi rere kiloraidi |
| Ọrinrin (KF) | 7.0% ~ 9.0% w/w |
| Aloku lori Iginisonu | ≤0.10% |
| Awọn irin Heavy | ≤20ppm |
| Irinotecan Hydrochloride Enantiomer | ≤0.10% (HPLC) |
| 7-Desethyl Irinotecan | ≤0.15% |
| Irinotecan ti o jọmọ agbo A | ≤0.15% |
| 11-Ethyl Irinotecan | ≤0.15% |
| Camptothecin | ≤0.15% |
| Irinotecan ibatan yellow B | ≤0.15% |
| 7-Ethylcanptothecin | ≤0.15% |
| 7,11-Diethyl-10-Hydroxy Camptothecin | ≤0.15% |
| Eyikeyi Aisọye Aimọ | ≤0.10% |
| Lapapọ Awọn Aimọ | ≤0.50% |
| Awọn ojutu ti o ku (GC) | |
| kẹmika kẹmika | ≤2000ppm |
| Acetone | ≤2000ppm |
| Dichloromethane | ≤500ppm |
| Peteoleum Eter: | ≤100ppm |
| Ethyl acetate | ≤2000ppm |
| Benzene | ≤2ppm |
| Awọn endotoxins kokoro arun | ≤0.29 EU/mg Irinotecan |
| Makirobia ifilelẹ | Lapapọ Nọmba Makirobia Aerobic: <1000 cfu/g |
| Molds ati iwukara | <100 cfu/g |
| Mimọ / Analysis Ọna | ≥99.0% (HPLC, lori ipilẹ anhydrous) |
| Igbeyewo Standard | United States Pharmacopeia (USP) Standard |
| Lilo | Ohun elo elegbogi ti nṣiṣe lọwọ (API) |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
lrinotecan hydrochloride (CAS 100286-90-6), ologbele-sintetiki kan, itọsẹ omi ti o yo ti oluranlowo anticancer camptothecin ti o lagbara, ni a ṣe ifilọlẹ ni Japan fun itọju ẹdọfóró, ovarian, ati awọn aarun inu oyun.lrinotecan n ṣiṣẹ iṣẹ antitumor rẹ nipasẹ idinamọ ti topoisomerase I, enzymu cellular kan ti o ni ipa ninu titọju igbekalẹ topographic ti DNA lakoko ilana ti itumọ, transcription, ati mitosis.lrinotecan faragba de-esterification ni vivo lati so metabolite ti nṣiṣe lọwọ, SN-38, eyiti o jẹ 1000-agbo diẹ sii ni agbara ju obi lọ.Itọju ailera apapọ ti irinotecan pẹlu oluranlowo anticancer miiran ti o gbajumo, cisplatin, ni a ti royin pe o ga julọ si boya aṣoju nikan.lrinotecan wa ninu awọn idanwo ile-iwosan fun ikun ikun, igbaya, awọ ara, awọ awọ, awọn aarun pancreatic, mesothelioma ati lymphoma ti kii-Hodgkin.
