Irinotecan Hydrochloride Trihydrate CAS 136572-09-3 API Factory High Purity
Ipese Olupese Irinotecan ati Awọn agbedemeji ti o jọmọ:
Irinotecan Hydrochloride CAS: 100286-90-6
Irinotecan Free Base CAS: 97682-44-5
Irinotecan Hydrochloride Trihydrate CAS: 136572-09-3
7-Ethyl-10-Hydroxycamptothecin CAS: 86639-52-3
1-Chlorocarbonyl-4-Piperidinopiperidine Hydrochloride CAS: 143254-82-4
| Orukọ Kemikali | Irinotecan Hydrochloride Trihydrate |
| Awọn itumọ ọrọ sisọ | Irinotecan HCl Trihydrate;CPT-11 Trihydrate;Irinotecan HCL 3H2O |
| Nọmba CAS | 136572-09-3 |
| NỌMBA CAT | RF-API52 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C33H38N4O6 · HCl · 3H2O |
| Òṣuwọn Molikula | 677.20 |
| Ojuami Iyo | 250.0 ~ 256.0 ℃ (oṣu kejila) |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Ina Yellow tabi Yellow Crystalline Powder |
| Ayẹwo (w/w) | 98.0% ~ 102.0% |
| Mimọ (HPLC) | ≥99.5% |
| Solubility | Tiotuka die-die ninu omi, ethanol tabi chloroform, Ni iṣe ti ko ṣee ṣe ni acetone |
| Idanimọ | nipasẹ IR ati HPLC, Awọn ibamu |
| Specific Optical Yiyi | +60°~+73° |
| Omi | 7.0% ~ 9.0% |
| Aloku ti Solvents | Ni ibamu pẹlu awọn ibeere ICH |
| Aloku lori Iginisonu | ≤0.20% |
| Kloride | 5.0% ~ 6.0% |
| Iye pH | 3.0 ~ 5.0 |
| Awọn irin Heavy | ≤20ppm |
| Olukuluku Egbin | ≤0.10% |
| Lapapọ Awọn Aimọ | ≤0.50% |
| Ibi ipamọ Ipo | Fipamọ ni 2-8 ° C, Ni awọn apoti ti a fi edidi ati aabo lati ina ati ọrinrin |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Ohun elo elegbogi ti nṣiṣe lọwọ (API) |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Shanghai Ruifu Kemikali Co., Ltd jẹ oluṣakoso asiwaju ati olupese ti Irinotecan Hydrochloride Trihydrate (CAS: 136572-09-3) pẹlu didara to gaju.
Irinotecan Hydrochloride Trihydrate jẹ topoisomerase I inhibitor ti a lo nipataki lati ṣe itọju akàn inu inu ati akàn rectal, idilọwọ isọdọkan ti okun DNA nipa dipọ mọ eka topoisomerase I-DNA.lrinotecan hydrochloride, ologbele-synthetic, itọsẹ omi ti o yo ti oluranlowo anticancer camptothecin ti o lagbara, ni a ṣe ifilọlẹ ni Japan fun itọju ẹdọfóró, ovarian, ati awọn aarun inu oyun.lrinotecan n ṣiṣẹ iṣẹ antitumor rẹ nipasẹ idinamọ ti topoisomerase I, enzymu cellular kan ti o ni ipa ninu titọju igbekalẹ topographic ti DNA lakoko ilana ti itumọ, transcription, ati mitosis.lrinotecan faragba de-esterification ni vivo lati so metabolite ti nṣiṣe lọwọ, SN-38, eyiti o jẹ 1000-agbo diẹ sii ni agbara ju obi lọ.Botilẹjẹpe jijẹ majele ti o kere pupọ ju camptothecin, nọmba pataki ti awọn alaisan ninu awọn idanwo ile-iwosan ṣe afihan awọn ipa ẹgbẹ ti leukopenia, igbuuru, ríru, ati alopecia.Itọju ailera apapọ ti irinotecan pẹlu oluranlowo anticancer miiran ti o gbajumo, cisplatin, ni a ti royin pe o ga julọ si boya aṣoju nikan.lrinotecan wa ninu awọn idanwo ile-iwosan fun ikun ikun, igbaya, awọ ara, awọ awọ, awọn aarun pancreatic, mesothelioma ati lymphoma ti kii-Hodgkin.
