Ivabradine Hydrochloride CAS 148849-67-6 Mimọ>99.5% (HPLC) Ile-iṣẹ API
Ipese Kemikali Ruifu Ivabradine Hydrochloride Intermediates Pẹlu Iwa mimọ to gaju
Ivabradine Hydrochloride CAS 148849-67-6
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Orukọ Kemikali | Ivabradine Hydrochloride |
Awọn itumọ ọrọ sisọ | Ivabradine HCl |
Nọmba CAS | 148849-67-6 |
NỌMBA CAT | RF-PI1812 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C27H36N2O5·HCl |
Òṣuwọn Molikula | 505.05 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun lati Pa-White Crystalline Powder |
Idanimọ | HPLC/UV ni ibamu |
Mimọ / Analysis Ọna | > 99.5% |
Pipadanu lori Gbigbe | <1.00% (Gbẹ ni 105 ℃ ninu ẹrọ gbigbẹ afẹfẹ ina mọnamọna titi di iwuwo igbagbogbo) |
Ọrinrin akoonu | <1.00% |
Aloku lori Iginisonu | <0.20% |
Max Nikan Aimọ | <0.50% |
Lapapọ Awọn Aimọ | <0.50% |
Isomer opitika | <0.50% |
Ayẹwo | > 99.5% |
Awọn irin Heavy | <20ppm |
Yiyi pato | +6.5° ~ +8.5° (lori ipilẹ gbigbẹ, ojutu 1% ni DMSO) |
Igbeyewo Standard | Standard Enterprise |
Lilo | API |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Ivabradine Hydrochloride (CAS: 148849-67-6),Ninu igbiyanju lati ṣe idagbasoke awọn aṣoju angina laisi inotropic odi ti aifẹ ati awọn ipa hypotensive ti o ni nkan ṣe pẹlu b-adrenergic blockers ati awọn oludena ikanni kalisiomu, kilasi tuntun ti oṣuwọn ọkan ti o dinku awọn agbo ogun ti o ṣiṣẹ ni pato lori node sinoatrial (SA) ti ṣawari.Awọn aṣoju bradycardic wọnyi ṣe ajọṣepọ taara pẹlu sẹẹli afọwọṣe ti oju ipade SA ati hyperpolarization- mu ṣiṣẹ Ti o ba jẹ lọwọlọwọ iyara mimu akọkọ.Ivabradine ti wa bi oludena kan pato ti Ti o ba wa lọwọlọwọ nipasẹ olubasọrọ rẹ pẹlu f-ikanni ni ẹgbẹ intracellular ti awọ ara pilasima.Bi abajade, Ivabradine dinku iyara ti diastolic depolarization ati dinku oṣuwọn ọkan.O ti fọwọsi fun itọju ti angina iduroṣinṣin onibaje ati pese yiyan ti o le yanju si awọn alaisan pẹlu ilodisi tabi aibikita ti awọn oludena b.Atunyẹwo tun wa fun itọju ti o pọju ti arun ọkan ischemic.