Lasofoxifene Tartrate CAS 190791-29-8 Mimọ Chiral ≥99.0% Mimọ
Ipese Olupese pẹlu Iwa-mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: Lasofoxifene Tartrate
CAS: 190791-29-8
Lasofoxifene Tartrate (CAS: 190791-29-8) ni itọju Postmenopausal Osteoporosis
Orukọ Kemikali | Lasofoxifene Tartrate |
Awọn itumọ ọrọ sisọ | (5R,6S) -5,6,7,8-Tetrahydro-6-phenyl-5-[4-[2- (1-pyrrolidinyl) ethoxy] phenyl] -2-naphthalenol Tartrate Oporia |
Nọmba CAS | Ọdun 190791-29-8 |
NỌMBA CAT | RF-API20 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C28H31NO2.ClH |
Òṣuwọn Molikula | 450.019 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun to Pa-White Powder |
Ọrinrin (KF) | ≤0.50% |
Awọn irin Heavy | ≤20ppm |
Chiral Mimọ | ≥99.0% |
Mimọ / Analysis Ọna | ≥98.0% (HPLC) |
Pipadanu lori Gbigbe | ≤0.50% |
Aloku lori Iginisonu | ≤0.50% |
Igbeyewo Standard | Pharmacopoeia Kannada (CP);Standard Enterprise |
Lilo | Ohun elo elegbogi ti nṣiṣe lọwọ (API);Osteoporosis postmenopausal |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ati olupese ti Lasofoxifene Tartrate (CAS: 190791-29-8) pẹlu didara to gaju.
Lasofoxifene Tartrate jẹ iran-kẹta kan, ti kii-sitẹriọdu yiyan estrogen receptor modulator (SERM).O ni yiyan sopọ mọ ERalpha eniyan pẹlu iye IC50 ti 1.5 nM ati ṣe idiwọ pipadanu egungun ni awọn eku ovariectomized.Ninu awọn iwadii ile-iwosan ti osteoporosis postmenopausal, 0.5 mg / ọjọ lasofoxifene ni nkan ṣe pẹlu awọn ewu ti o dinku ti awọn eewu ti kii ṣe vertebral ati vertebral, ER-positive akàn igbaya, arun ọkan iṣọn-alọ ọkan, ati ọpọlọ ṣugbọn eewu ti o pọ si ti awọn iṣẹlẹ thromboembolic iṣọn-ẹjẹ.Lasofoxifene tun ti han lati ṣe bi agonist onidakeji ni olugba CB2 cannabinoid, nfihan agbara rẹ lati tun pada bi itọju ailera fun awọn itọkasi nibiti CB2 jẹ ibi-afẹde.