LCZ696 Intermediate CAS 1426129-50-1 Mimọ
Ipese Iṣowo LCZ696 (CAS: 936623-90-4) Awọn agbedemeji ti o jọmọ:
(R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R, E) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S) -ethyl 5- (1,1'-biphenyl-4-yl) -4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (iyọ hemicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Adalu Sacubitril pẹlu Valsartan CAS: 936623-90-4
| Orukọ Kemikali | (R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate |
| Awọn itumọ ọrọ sisọ | LCZ696 Agbedemeji |
| Nọmba CAS | 1426129-50-1 |
| NỌMBA CAT | RF-PI169 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
| Ilana molikula | C20H25NO3 |
| Òṣuwọn Molikula | 327.42 |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun to Pa-White Powder |
| Mimọ / Analysis Ọna | ≥98.0% (HPLC) |
| Enantiomeric Excess | ee: ≥99.0% |
| Ọrinrin (KF) | ≤1.0% |
| Awọn nkan ti o jọmọ A | ≤1.0% (RRT=0.5) A=(R) -3-([1,1'-biphenyl]-4-yl)-2-aminopropan-1-ol |
| Awọn nkan ti o jọmọ B | ≤1.0% (RRT=0.85) B=Afẹfẹ Triphenylphosphine |
| Awọn nkan miiran | ≤1.0% |
| Lapapọ Awọn Aimọ | ≤2.0% |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Agbedemeji ti LCZ696 (CAS: 936623-90-4) ni itọju HFrEF |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Olupese pẹlu Ga ti nw ati Idurosinsin Didara
Ipese Iṣowo LCZ696 (CAS: 936623-90-4) Awọn agbedemeji ti o jọmọ:
(R) -tert-Butyl (1- ([1,1-biphenyl] -4-yl) -3-hydroxypropan-2-yl) carbamate CAS: 1426129-50-1
(R, E) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpent-2-enoic acid CAS: 1012341-48-8
(2R,4S) -5- (1,1'-biphenyl-4-yl) -4- ((tert-butoxycarbonyl) amino) -2-methylpentanoic acid CAS: 1012341-50-2
(2R,4S) -ethyl 5- (1,1'-biphenyl-4-yl) -4-amino-2-methylpentanoate HCl CAS: 149690-12-0
AHU-377 (iyọ hemicalcium) CAS: 1369773-39-6
AHU-377;Sacubitril CAS: 149709-62-6
LCZ696;Entresto;Adalu Sacubitril pẹlu Valsartan CAS: 936623-90-4
LCZ696 jẹ oogun adanwo ti o dagbasoke nipasẹ Novartis Pharmaceutical ti Orilẹ Amẹrika fun itọju awọn alaisan ti o ni Ikuna Ọkàn pẹlu Idinku Ejection (HFrEF).Ikuna ọkan jẹ arun ti o lewu.Ọkàn alaisan ko le fa ẹjẹ ti o to lati pese ara, ati pe o han awọn aami aiṣan ti dyspnea, rirẹ ati idaduro omi laiyara, lẹhinna pọsi ni ilọsiwaju, ni ipa lori didara igbesi aye.LCZ696 le ṣe alekun aabo ara ti ara lodi si ikuna ọkan, bakanna bi alekun ipele ti awọn peptides natriuretic ati awọn peptides vasoactive miiran ti endogenous, ati ṣe idiwọ eto renin-angiotensin-aldosterone (RAAS).LCZ696 ti ni idapo pẹlu oogun Haipatensonu Novartis (Diovan, orukọ jeneriki: valsartan) ati oogun idanwo AHU-377.AHU377 ṣe idiwọ ẹrọ ti awọn peptides meji ti o ni iduro fun idinku titẹ ẹjẹ.Diovan ṣe ilọsiwaju vasodilatation ati ki o ṣe iwuri fun ara lati yọ iṣuu soda ati omi jade.
