Lenvatinib Mesylate Intermediate CAS 205448-65-3 Mimọ> 98.0% (HPLC) Ile-iṣẹ
Ipese Kemikali Ruifu Lenvatinib Mesylate Intermediates Pẹlu Iwa mimọ to gaju
Lenvatinib Mesylate CAS 857890-39-2
4-Chloro-7-Methoxyquinoline-6-Carboxamide CAS 417721-36-9
Desquinolinyl Lenvatinib;1- (2-Chloro-4-Hydroxyphenyl) -3-Cyclopropylurea CAS 796848-79-8
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate CAS 205448-65-3
Methyl 4-Amino-2-Methoxybenzoate CAS 27492-84-8
5- (Methoxymethylene) -2,2-Dimethyl-1,3-Dioxane-4,6-Dion CAS 15568-85-1
4-Amino-3-Chlorophenol CAS 17609-80-2
4-Amino-3-Chlorophenol Hydrochloride CAS 52671-64-4
Methyl 4-Chloro-7-Methoxyquinoline-6-Carboxylate CAS 205448-66-4
Orukọ Kemikali | Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate |
Awọn itumọ ọrọ sisọ | 1,4-Dihydro-7-Methoxy-4-Oxo-6-Quinolinecarboxylic Acid Methyl Ester;7-Methoxy-4-Oxo-1,4-Dihydro-Quinoline-6-Carboxylic Acid Methyl Ester;Agbedemeji Lenvatinib 3 |
Nọmba CAS | 205448-65-3 |
NỌMBA CAT | RF-PI1973 |
Iṣura Ipo | Ni Iṣura, Agbara iṣelọpọ 50 MT / Ọdun |
Ilana molikula | C12H11NO4 |
Òṣuwọn Molikula | 233.22 |
Ojuami farabale | 421,0 ± 45,0 ℃ |
iwuwo | 1,267 ± 0,060 g / cm3 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Pa-White to Yellowish Powder |
Mimọ / Analysis Ọna | > 98.0% (HPLC) |
Pipadanu lori Gbigbe | <1.00% |
Aloku lori Iginisonu | <0.50% |
Lapapọ Awọn Aimọ | <2.00% |
H-NMR | Ni ibamu si Eto |
Igbeyewo Standard | Standard Enterprise |
Lilo | elegbogi Intermediates |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Methyl 7-Methoxy-4-Oxo-1,4-Dihydroquinoline-6-Carboxylate (CAS: 205448-65-3) jẹ agbedemeji ti Lenvatinib Mesylate (CAS: 857890-39-2).Lenvatinib, ti a ta labẹ orukọ iyasọtọ Lenvima laarin awọn miiran, jẹ oogun egboogi-akàn fun itọju awọn iru kan ti akàn tairodu ati fun awọn aarun miiran bi daradara.O jẹ idagbasoke nipasẹ Eisai Co. ati pe o ṣe bi oludena kinase pupọ si VEGFR1, VEGFR2 ati VEGFR3 kinases.Lenvatinib ti fọwọsi (niwon 2015) fun itọju ti akàn tairodu ti o yatọ ti o jẹ ti agbegbe ti o nwaye tabi metastatic, ilọsiwaju, ati pe ko dahun si itọju pẹlu iodine ipanilara (radioiodine).Ni Oṣu Karun ọdun 2016, Awọn ipinfunni Ounje ati Oògùn AMẸRIKA (FDA) fọwọsi rẹ (ni apapo pẹlu everolimus) fun itọju ti carcinoma sẹẹli kidirin to ti ni ilọsiwaju ti o tẹle ọkan ṣaaju iṣaaju itọju anti-angiogenic.Oogun naa tun fọwọsi ni AMẸRIKA ati ni European Union fun carcinoma hepatocellular ti a ko le yọkuro ni abẹ ni awọn alaisan ti ko gba itọju alakan nipasẹ ẹnu tabi abẹrẹ.