Lesinurad (RDEA 594) CAS 878672-00-5 Mimọ>99.5% (HPLC) Agbeyewo 98.0 ~ 102.0%
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Lesinurad (RDEA 594) (CAS: 878672-00-5) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Lesinurad ati Intermediates,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Lesinurad |
| Awọn itumọ ọrọ sisọ | 2-[[5-Bromo-4- (4-Cyclopropylnaphthalen-1-yl)-4H-1,2,4-Triazol-3-yl]thio] acetic Acid;2-[[5-Bromo-4- (4-Cyclopropyl-1-Naphthalenyl)-4H-1,2,4-Triazol-3-yl]thio] -Acetic Acid;RDEA 594;RDEA-594;RDEA594;Zurampic |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 878672-00-5 |
| Fọọmu Molecular | C17H14BrN3O2S |
| Òṣuwọn Molikula | 404,28 g / mol |
| Ojuami Iyo | > 171 ℃ (oṣu kejila) |
| iwuwo | 1,72 ± 0,10 g / cm3 |
| COA & MSDS | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Funfun to Pa-White Powder | Pa-White Powder |
| Idanimọ | Akoko idaduro ti oke pataki ti ojutu ayẹwo ni ibamu si boṣewa itọkasi | Ibamu |
| Omi nipa Karl Fischer | <0.50% | 0.14% |
| Aloku lori Iginisonu | <0.10% | 0.03% |
| Awọn Irin Eru (Pb) | ≤10ppm | <10ppm |
| Awọn nkan ti o jọmọ (HPLC) | ||
| Awọn Tobi Nikan aimọ | <0.20% | 0.07% |
| Lapapọ Awọn Aimọ | <1.00% | 0.24% |
| Mimọ / Analysis Ọna | > 99.5% (Agbegbe HPLC) | 99.76% |
| Ayẹwo | 98.0 ~ 102.0% | 99.6% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Lesinurad (RDEA 594) (CAS: 878672-00-5) jẹ ifọwọsi nipasẹ Ile-iṣẹ Ounje ati Oògùn AMẸRIKA (FDA) ni Oṣu kejila ọjọ 22, ọdun 2015, ati lẹhinna fọwọsi nipasẹ Ile-iṣẹ Oogun Yuroopu (EMA) ni Oṣu Keji ọjọ 18, Ọdun 2016. yellow ti a sẹyìn ni idagbasoke nipasẹ Ardea.AstraZeneca gba ile-iṣẹ ni ọdun 2012, eyiti o gba ọja naa.Orukọ iṣowo oogun naa jẹ Zurampic® ni Amẹrika ati European Union.Lesinurad jẹ oludena gbigbe urate reuptake (URAT1) akọkọ ti a fọwọsi ni agbaye, ni idapo pẹlu awọn inhibitors xanthine oxidase lati tọju gout ti o ni ibatan hyperuricemia.
Lesinurad, isowo orukọ Zurampic.Lesinurad ni apapo pẹlu onidalẹkun xanthine oxidase (XOI) fun iṣọn-ẹjẹ gout hyperuricemia.Ilana iṣe rẹ ni lati ṣe iranlọwọ fun awọn kidinrin lati yọ uric acid jade, ati pe o ṣiṣẹ nipa didi iṣẹ ti awọn gbigbe ti o ni ipa ninu isọdọtun uric acid ninu awọn kidinrin.
Lesinurad ṣe idiwọ iṣẹ gbigbe uric acid (IC50 = 3.36 μM) ti hURAT1 (URAT1 eniyan), eyiti o jẹ diẹ sii ju awọn akoko 20 ni ipa inhibitory lori rURAT1 (rat URAT1) (IC50=74.84 μM).Lesinurad ṣe idiwọ hURAT1 nipasẹ ibaraenisepo ti bọtini amino acid iyokù Phe365.
