Potassium Losartan CAS 124750-99-8 API Ilé-iṣẹ́ Antihypertensive High Purity
Ipese Potasiomu Losartan ati Awọn agbedemeji ibatan pẹlu Didara Giga
Losartan Potasiomu CAS 124750-99-8
2-Butyl-4-Chloro-5-Formylimidazole (BCFI) CAS 83857-96-9
| Orukọ Kemikali | Potasiomu Losartan |
| Awọn itumọ ọrọ sisọ | DuP 753;Cozaar;2-Butyl-4-chloro-1-[[2'-( 1H-tetrazol-5-yl)-1,1'-biphenyl-4-yl]methyl] imidazole-5-methanol Potassium Salt |
| Nọmba CAS | 124750-99-8 |
| NỌMBA CAT | RF-API98 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C22H22ClKN6O |
| Òṣuwọn Molikula | 461.01 |
| Ojuami Iyo | 263.0 ~ 265.0 ℃ |
| Solubility | Soluble Larọwọto ninu Omi ati ni kẹmika, Soluble Diẹ ni Acetonitrile. |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Fere White Crystalline Powder |
| Idanimọ A | Gbigba infurarẹẹdi: Gbọdọ Iruran si Standard Reference |
| Idanimọ B | Gbigba Ultraviolet: Gbọdọ Iru si Standard Reference |
| Idanwo fun potasiomu | Gbọdọ jẹ Rere |
| Akoonu Omi (KF) | ≤0.50% |
| Awọn irin Heavy | ≤10ppm |
| Awọn nkan ti o jọmọ (HPLC) | |
| Eyikeyi Olukuluku aimọ | ≤0.20% |
| Lapapọ Awọn Aimọ | ≤0.50% |
| Awọn ojutu ti o ku (GC) | |
| Cyclohexane | ≤0.10% |
| isopropyl Ọtí | ≤0.20% |
| Aseyori / Analysis Ọna | 98.5 ~ 101.0% (HPLC, iṣiro lori anhydrous, ipilẹ ti ko ni epo) |
| N-Nitrosodiethylamine | ≤0.177ppm (NDEA) |
| N-Nitrosodimethylamine | ≤0.640ppm (NDMS) |
| Patiku Iwon | 90% Kere Ju 38 Microns |
| Igbesi aye selifu | 24 osu |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API, Angiotensin II Olugba Atagbo Antihypertensive |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Potasiomu Losartan jẹ agbara akọkọ ati yiyan ti kii-peptide angiotensin II olugba olugba 1 (AT1) antagonist ti a ṣafihan si ọja bi oogun antihypertensive ẹnu-ẹẹkan lojoojumọ.Ifojusi ti o ṣe idiwọ 50% ti abuda angiotensin II (IC50) jẹ 20 nM.Losartan (40 μM) kan ISC ṣugbọn ṣe idiwọ ipa ti ANGII lori ISC.Losartan ni pataki dinku isọdi sẹẹli ti aarin Ang II ninu awọn sẹẹli alakan endometrial.Apapo losartan ati anti-miR-155 ni ipa ipa antiproliferative ti o tobi pupọ ni akawe si oogun kọọkan nikan.O jẹ metabolized lati ṣe agbejade 5-carboxylic acid metabolite (EXP3174) ati pe a royin lati dinku titẹ ẹjẹ.O n ṣe iwadii lọwọlọwọ bi itọju ti o pọju fun COVID-19 fun agbara rẹ lati dinku tabi o ṣee ṣe idinku awọn ami aisan ti COVID-19.
1. Fun itọju haipatensonu pataki, o le ṣee lo nikan tabi ni apapo pẹlu awọn oogun antihypertensive miiran (gẹgẹbi awọn diuretics).2. Fun itọju ikuna ọkan, o le ṣee lo nikan tabi ni apapo pẹlu cardiotonic tabi awọn oogun Kemikali diuretic.3. Idilọwọ ikọlu ni awọn alaisan ti o ni haipatensonu ati hypertrophy ventricular osi.4. A lo lati fa fifalẹ ilọsiwaju ti nephropathy ni awọn alaisan ti o ni àtọgbẹ iru 2 ti o ni nkan ṣe pẹlu nephropathy ati haipatensonu.
