N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1 Purity>99.0% (HPLC) Afatinib Dimaleate Intermediate Factory

Apejuwe kukuru:

Orukọ Kemikali: N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine

CAS: 162012-67-1

Mimọ:> 99.0% (HPLC)

Irisi: Imọlẹ Yellow to Yellow Powder

Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

E-Mail: alvin@ruifuchem.com

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ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine
Awọn itumọ ọrọ sisọ	N- (3-Chloro-4-Fluorophenyl) -7-Fluoro-6-Nitro-4-Quinazolinamine;(3-Chloro-4-Fluorophenyl) (7-Fluoro-6-Nitroquinazolin-4-yl) amine;4- (3-Chloro-4-Fluoroanilino) -7-Fluoro-6-Nitroquinazoline;Afatinib Intermediate A
Nọmba CAS	162012-67-1
NỌMBA CAT	RF-PI2026
Iṣura Ipo	Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Ilana molikula	C14H7ClF2N4O2
Òṣuwọn Molikula	336.68
Ifamọ	Afẹfẹ Sensitive, Ooru kókó
Ojuami Iyo	242.0 ~ 244.0 ℃
Ojuami farabale	489 ℃
iwuwo	1.616
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Ina Yellow to Yellow Powder
Mimọ / Analysis Ọna	> 99.0% (HPLC)
Pipadanu lori Gbigbe	<0.50%
Aloku lori Iginisonu	<0.20%
Awọn nkan ti o jọmọ
Olukuluku Aimọ	<0.50%
Lapapọ Awọn Aimọ	<1.00%
Awọn irin Heavy	≤20ppm
Infurarẹẹdi julọ.Oniranran	Ni ibamu si Eto
Proton NMR julọ.Oniranran	Ni ibamu si Eto
Igbeyewo Standard	Standard Enterprise
Lilo	Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

FAQ:

Ohun elo:

N- (3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine (CAS: 162012-67-1) jẹ agbedemeji ninu iṣelọpọ ti Afatinib Dimaleate (CAS: 850140-73-7) .Afatinib Dimaleate jẹ iyọ ti Afatinib.Afatinib jẹ iran-keji, ti a nṣakoso ẹnu, oludanukonu ti ko le yipada ti idile ErbB ti kinases tyrosine.Mechanism of ActionAfatinib downregulates ErbB ifihan agbara nipa covalently abuda si awọn agbegbe kinase ti epidermal idagbasoke ifosiwewe receptor (EGFR), eda eniyan epidermal idagbasoke ifosiwewe receptor (HER) 2 ati HER4, Abajade ni irreversible idinamọ ti tyrosine kinase autophosphorylation;o tun ṣe idiwọ transphosphorylation ti HER3.Afatinib jẹ itẹwọgba bi monotherapy fun itọju EGFR tyrosine kinase inhibitor (TKI) -awọn agbalagba alaigbọwọ pẹlu ilọsiwaju agbegbe tabi DefinitionChEBI: iyọ maleate ti a gba nipasẹ apapọ afatinib pẹlu awọn deede molar meji ti maleic acid.Ti a lo fun itọju laini akọkọ ti awọn alaisan ti o ni akàn ẹdọfóró ti kii-kekere sẹẹli.