N(4)-Hydroxycytidine CAS 3258-02-4 EIDD-1931 NHC Didara Didara
Ipese pẹlu Iwa mimọ giga ati Didara Idurosinsin
Orukọ Kemikali: N (4) -Hydroxycytidine;EIDD-1931 (NHC)
CAS: 3258-02-4
Metabolite ti nṣiṣe lọwọ ti Molnupiravir, oludena COVID-19 ti o ni ileri
| Orukọ Kemikali | N (4) -Hydroxycytidine |
| Awọn itumọ ọrọ sisọ | EIDD-1931 (NHC);β-D-N4-Hydroxycytidine |
| Nọmba CAS | 3258-02-4 |
| NỌMBA CAT | RF-PI309 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Kilograms |
| Fọọmu Molecular | C9H13N3O6 |
| Òṣuwọn Molikula | 259.22 |
| Ojuami Iyo | 169.0 ~ 172.0 ℃ |
| Solubility | Tiotuka si 100 mM ni DMSO ati si 50 mM ninu Omi |
| iwuwo | 1,93 ± 0,1 g / cm3 |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun to Pa-White Powder |
| NMR | Ni ibamu pẹlu Eto |
| Mimọ / Analysis Ọna | > 98% (HPLC) |
| Pipadanu lori Gbigbe | ≤1.0% |
| Aimọ Kanṣoṣo | ≤0.50% |
| Awọn irin Heavy | ≤20ppm |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Metabolite ti nṣiṣe lọwọ ti Molnupiravir (EIDD-2801), oludena COVID-19 kan |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
N (4) -Hydroxycytidine (EIDD-1931, β-d-N4-hydroxycytidine, NHC, CAS 3258-02-4) jẹ metabolite ti nṣiṣe lọwọ ti EIDD-2801, oludena COVID-19 ti o ni ileri.EIDD-1931 (NHC) ni iṣẹ ṣiṣe antiviral ti o gbooro si ọpọlọpọ awọn coronaviruses, pẹlu SARS-CoV-2, MERS-CoV, SARS-CoV, ati ẹgbẹ zoonotic ti o ni ibatan 2b tabi 2c Bat-CoVs pẹlu apapọ IC50 ti 0.15 μM, bakanna bi agbara ti o pọ si lodi si awọn iyipada resistance ti o ru coronavirus si inhibitor afọwọṣe nucleoside remdesivir.Ninu awọn eku ti o ni arun SARS-CoV tabi MERS-CoV, mejeeji prophylactic ati iṣakoso itọju ti Molnupiravir (EIDD-2801), ohun elo NHC-prodrug ti ẹnu (β-D-N4-hydroxycytidine-5'-isopropyl ester), ilọsiwaju iṣẹ ẹdọforo. , ati idinku titer kokoro ati pipadanu iwuwo ara.Awọn ikore MERS-CoV ti o dinku ni fitiro ati in vivo ni o ni nkan ṣe pẹlu igbohunsafẹfẹ iyipada iyipada ti o pọ si ni gbogun ti ṣugbọn kii ṣe sẹẹli RNA gbalejo, n ṣe atilẹyin ẹrọ ti mutagenesis apaniyan ni CoV.Agbara ti NHC/EIDD-2801 lodi si awọn coronaviruses pupọ ati bioavailability ti ẹnu ṣe afihan ohun elo ti o pọju bi apakokoro ti o munadoko lodi si SARS-CoV-2 ati awọn coronaviruses zoonotic miiran iwaju.
