Palbociclib CAS 571190-30-2 Mimọ> 99.5% (HPLC) API Factory
Ipese Kemikali Ruifu Palbociclib Awọn agbedemeji ibatan:
Palbociclib CAS 571190-30-2
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Orukọ Kemikali | Palbociclib |
Awọn itumọ ọrọ sisọ | PD-0332991;Otava-Bb 1115529;Ibrance |
Nọmba CAS | 571190-30-2 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C24H29N7O2 |
Òṣuwọn Molikula | 447.54 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Pa-White Powder |
1H NMR julọ.Oniranran | Ni ibamu Pẹlu Be |
HPLC | Ni ibamu Pẹlu Be |
Awọn nkan ti o jọmọ | |
Olukuluku Aimọ | <0.50% |
Lapapọ Awọn Aimọ | <1.00% |
Pipadanu lori Gbigbe | <0.50% |
Aloku lori Iginisonu | <0.10% |
Awọn irin Heavy | <10ppm |
Mimọ / Analysis Ọna | > 99.5% (HPLC) |
Igbeyewo Standard | Standard Enterprise |
Lilo | API, Ninu Itọju Akàn Ọyan |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Palbociclib (CAS: 571190-30-2) jẹ inhibitor cyclin-dependent kinase (CDK) ti o wa ni ẹnu pẹlu iṣẹ antineoplastic ti o pọju.Palbociclib yiyan ṣe idiwọ cyclin-based kinase 4 (CDK4) ati 6 (CDK6), nitorinaa idinamọ retinoblastoma (Rb) phosphorylation amuaradagba ni kutukutu ipele G1 ti o yori si idaduro ọmọ sẹẹli.Eyi dinku ẹda DNA ati dinku isọdi sẹẹli tumo.Palbociclib jẹ aṣoju akọkọ ti kilasi oogun tuntun ti awọn inhibitors kinase ti o gbẹkẹle cyclin.Ipa yii ṣe opin si ilọsiwaju sẹẹli (idagbasoke sẹẹli ati pipin).O ti wa ni lilo bi ohun antineoplastic oluranlowo ni ilọsiwaju tabi metastatic igbaya akàn.