Pirfenidone CAS 53179-13-8 Mimọ ≥99.0% IPF
Ipese Pẹlu Iwa mimọ giga, iṣelọpọ Iṣowo
Orukọ Kemikali: Pirfenidone
CAS: 53179-13-8
| Orukọ Kemikali | Pirfenidone |
| Awọn itumọ ọrọ sisọ | Perfenidone;5-Methyl-1-Phenylpyridine-2 (1H) - ọkan;PFD;S-7701;AMR-69 |
| Nọmba CAS | 53179-13-8 |
| NỌMBA CAT | RF-API108 |
| Iṣura Ipo | O wa |
| Fọọmu Molecular | C12H11NO |
| Òṣuwọn Molikula | 185.22 |
| Ojuami Iyo | 96.0 si 97.0 ℃ |
| Solubility | Tiotuka ni DMSO |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun to Light Yellow Crystalline Powder |
| Idanimọ | IR |
| Mimo | ≥99.0% |
| Pipadanu lori Gbigbe | ≤0.50% |
| Sulfated Ash | ≤0.20% |
| Nikan Aimọ | ≤0.50% |
| Lapapọ Awọn Aimọ | ≤1.0% |
| Awọn Irin Eru | ≤20ppm |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API, Fibrosis ẹdọforo Idiopathic (IPF) |
Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.
Pirfenidone (CAS: 53179-13-8) wa ninu ẹgbẹ awọn oogun ti a npe ni awọn aṣoju antifibrotic.Pirfenidone ti ṣe afihan iṣẹ-ṣiṣe ni awọn ipo fibrotic pupọ, pẹlu awọn ti ẹdọfóró, kidinrin ati ẹdọ.O ni ipa lori eto ajẹsara ti ara rẹ ati dinku iye fibrosis (scaring) ninu ẹdọforo.Pirfenidone jẹ ọkan ninu awọn oogun meji ti a fọwọsi ni Ilu Kanada lati ṣe itọju Idiopathic Pulmonary Fibrosis (IPF).Pirfenidone jẹ inhibitor fun iṣelọpọ TGF-β ati TGF-β ti o mu iṣelọpọ collagen, dinku iṣelọpọ ti TNF-a ati IL-1β, ati pe o tun ni awọn ohun-ini anti-fibrotic ati egboogi-iredodo.A kọkọ fọwọsi ni Ilu Japan fun itọju awọn alaisan ti o ni fibrosis ẹdọforo idiopathic lẹhin awọn idanwo ile-iwosan, labẹ orukọ iṣowo ti Pirespa nipasẹ Shionogi, ni 2008. O ti fọwọsi fun lilo ni European Union ni 2011, ni Canada ni 2012, ati ni Orilẹ Amẹrika ni Oṣu Kẹwa ọdun 2014.
