Posaconazole CAS 171228-49-2 API Factory Triazole Aṣoju Antifungal Didara Giga
Ipese Factory Posaconazole Awọn agbedemeji ibatan, iṣelọpọ Iṣowo
Posaconazole CAS 171228-49-2
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Orukọ Kemikali | Posaconazole |
Awọn itumọ ọrọ sisọ | POS;SCH 56592;4-[4-[4-[4-[[(3R,5R)] -5- (2,4-Difluorophenyl) -5- (1,2,4-triazol-1-ylmethyl) oxolan-3-yl] methoxy]phenyl] piperazin-1-yl] phenyl] -2-[(2S,3S) -2-hydroxypentan-3-yl] -1,2,4-triazol-3-ọkan |
Nọmba CAS | 171228-49-2 |
NỌMBA CAT | RF-API77 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C37H42F2N8O4 |
Òṣuwọn Molikula | 700.78 |
iwuwo | 1,36 g / cm3 |
Solubility | Tiotuka ni DMSO, Ailokun ninu Omi |
Sowo Ipò | Sowo Labẹ Ibaramu otutu |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun lati Pa-White Crystalline Powder |
Idanimọ A | IR: Iwọn ifasilẹ infurarẹẹdi ti ọja yẹ ki o wa ni ibamu pẹlu ti nkan itọkasi |
Idanimọ B | HPLC Idaduro akoko iru si itọkasi nkan na |
Ojuami Iyo | 167.0 ~ 171.0 ℃ |
Yiyi pato [a]20 | -24.0° ~ -28.0° (C=1, CHCL3) |
Omi (KF) | ≤1.0% |
Aloku lori Iginisonu | ≤0.10% |
Awọn nkan ti o jọmọ | |
HT 909-24 | ≤0.20% |
Eyikeyi Olukuluku aimọ | ≤0.10% |
Lapapọ Awọn Aimọ | ≤1.0% |
Awọn ohun elo ti o ku | |
kẹmika kẹmika | ≤3000ppm |
Methyl tert-Butyl Eteri | ≤5000ppm |
Isopropanol | ≤5000ppm |
Dimethyl sulfoxide | ≤5000ppm |
Dichloromethane | ≤600ppm |
Ayẹwo | 98.0% ~ 102.0% (Iṣiro lori ipilẹ ti o gbẹ) |
Awọn irin Heavy | ≤10ppm |
Isomer | Enantiomer ≤0.10% |
Eyikeyi Iwa Aimọ ≤0.10% | |
Lapapọ Awọn Idọti ≤1.0% | |
Igbeyewo Standard | Standard Enterprise;USP;BP;EP Standard |
Lilo | API, Triazole Antifungal Aṣoju |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Posaconazole (CAS 171228-49-2), jẹ gbooro-spekitiriumu, iran keji, triazole yellow pẹlu iṣẹ antifungal, ti a ṣe ifilọlẹ ni UK, jẹ ọmọ ẹgbẹ tuntun ti kilasi azole ti awọn aṣoju antifungal lati de ọja naa.O jẹ itọkasi fun itọju ati prophylaxis ti ọpọlọpọ awọn akoran olu ifarapa, pẹlu aspergillosis, fusariosis, chromoblastomycosis, mycetoma, ati coccidiomycosis ninu awọn alaisan ti o ni itara si, tabi alailagbara, itọju boṣewa pẹlu amphotericin B ati/tabi itraconazole.Ni AMẸRIKA, o fọwọsi fun prophylaxis ti Aspergillus invasive ati awọn akoran Candida ninu awọn alaisan ti o jẹ ọmọ ọdun 13 ti o wa ninu eewu giga ti idagbasoke awọn akoran wọnyi nitori jijẹ ajẹsara to lagbara.Ni afikun, o jẹ ifọwọsi fun itọju ti oropharyngeal candidiasis.Posaconazole ni iṣẹ ṣiṣe ti o gbooro sii lori awọn ọmọ ẹgbẹ miiran ti azole antifungals.Ni afikun si iṣẹ ṣiṣe ti o lagbara lodi si awọn ọran aspergillosis ati fluconazole-sooro Candida, o ṣe afihan iṣẹ ṣiṣe lodi si Zygomycetes.Posaconazole jẹ oogun antifungal triazole ti o ta ni Amẹrika nipasẹ Schering-Plough labẹ orukọ iṣowo Noxafil.