Pregabalin CAS 148553-50-8 Mimọ>99.0% (HPLC) API Antiepileptic
Olupese pẹlu Ga ti nw ati Commercial Production
Orukọ Kemikali: PregabalinCAS: 148553-50-8
Pregabalin jẹ oogun antiepileptic iran-keji (AED)
Orukọ Kemikali | Pregabalin |
Awọn itumọ ọrọ sisọ | (S) -3- (Aminomethyl) -5-Methylhexanoic Acid;PD-144723;PD144723;CI 1008;CI-1008;Lyrica |
Nọmba CAS | 148553-50-8 |
NỌMBA CAT | RF-API57 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C8H17NO2 |
Òṣuwọn Molikula | 159.23 |
Ojuami Iyo | 194.0 ~ 196.0 ℃ |
Solubility ninu Omi | Ailesolusan ninu Omi |
Solubility | Tiotuka pupọ ni Ethanol |
Sowo Ipò | Labẹ Ibaramu otutu |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun lati Pa-White Crystalline Powder |
Idanimọ | IR: Iru si nkan Itọkasi |
Yiyi pato | +10.0°~+13.0° (C=1, Omi) |
Pipadanu lori Gbigbe | <0.50% |
Sulfated Ash | <0.10% |
Awọn nkan ti o jọmọ | Aimọ A <0.15% |
Awọn ohun aimọ ti a ko ni pato Ṣaaju Pregabalin (idanwo A) <0.10% | |
Awọn ohun aimọ ti ko ni pato Lẹhin Pregabalin (idanwo B) <0.10% | |
Lapapọ fun idanwo A ati B <0.50% | |
Ti nw Nipa HPLC R-Isomer | <0.15% |
Awọn irin Heavy (gẹgẹbi Pb) | <10ppm |
Klorides (Cl) | <0.05% |
Awọn ohun elo ti o ku | |
isopropyl Ọtí | <5000ppm |
Ethyl acetate | <5000ppm |
Tetrahydrofuran | <250ppm |
Isopropyl Eteri | <500ppm |
Ethanol | <1000ppm |
Mimọ / Analysis Ọna | > 99.0% (HPLC lori ipilẹ gbigbẹ) |
Igbeyewo Standard | Standard Enterprise |
Lilo | Oògùn Antiepileptic API |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina & ọrinrin
Pregabalin jẹ oogun antiepileptic iran-keji (AED) ti a mọ pẹlu orukọ iyasọtọ ti Lyrica (Pfizer, Tadworth) ni UK ati AMẸRIKA, ti o ni eto γ-amino butyric acid lori eto molikula rẹ, eyiti o ni awọn ipa anticonvulsant, ati pe o jẹ ni ifijišẹ ni idagbasoke nipasẹ Pfizer ile-iṣẹ fun itọju ti irora neuropathic agbeegbe, tabi itọju adjuvant ti awọn ijakadi apakan.Pregabalin jẹ Anticonvulsant ati oogun apakokoro ti a lo lati ṣe itọju warapa, irora neuropathic, fibromyalgia, ati rudurudu aifọkanbalẹ gbogbogbo.Lilo rẹ fun warapa jẹ bi afikun itọju ailera fun awọn ijakadi apa kan pẹlu tabi laisi gbogboogbo Atẹle ni awọn agbalagba.Ni Oṣu Keji ọdun 2008, Ile-iṣẹ Ounje ati Oògùn AMẸRIKA (FDA) fọwọsi pregabalin (orukọ iṣowo “Lyrica”) fun itọju ti irora neuropathic agbeegbe dayabetik (DPN) ati neuralgia postherpetic (PHN) eyiti o jẹ mejeeji awọn irora neuropathic ti o wọpọ julọ.Pregabalin ni itọkasi ti a fọwọsi ati pe o jẹ lilo pupọ fun itọju ti rudurudu aifọkanbalẹ gbogbogbo.Orisirisi awọn laileto, afọju-meji, awọn idanwo iṣakoso ibibo rii pe pregabalin jẹ itọju to munadoko fun awọn alaisan ti o ni rudurudu aifọkanbalẹ gbogbogbo ati rudurudu aifọkanbalẹ awujọ.Iwọn titration warapa-adjunctive therapy: 25 mg bd fun awọn ọjọ 7, lati jẹ alekun nipasẹ 50 miligiramu ni gbogbo ọjọ 7;itọju deede 300 miligiramu lojoojumọ, pin si awọn iwọn 2 tabi 3 (max. 600 mg lojoojumọ, pin si awọn iwọn 2 tabi 3).Iṣoro aifọkanbalẹ gbogbogbo: 150 miligiramu lojoojumọ, pin si awọn iwọn 2 tabi 3, fun awọn ọjọ 7, lati jẹ alekun nipasẹ 150 mg ni gbogbo ọjọ 7 (max. 600 mg lojoojumọ, pin si awọn iwọn 2 tabi 3).Ti o ba da pregabalin duro, o gba ọ niyanju lati tẹ lori o kere ju ọsẹ 1 lati yago fun yiyọ kuro lojiji.Awọn iṣọra Awọn alaisan ti o ni awọn ipo ti o le fa encephalopathy.Awọn alaisan ti o ni ikuna ọkan iṣọn-ẹjẹ lile.