(R)-(-) 3-Pyrrolidinol Hydrochloride CAS 104706-47-0 Purity ≥99.7% (GC) Chiral Purity ≥99.7% Panipenem ati Darifenacin hydrobromide Intermediate
Ipese Olupese;Ga ti nw ati ifigagbaga Price
Shanghai Ruifu Kemikali Co., Ltd. Ipese Iṣowo Chiral Awọn akopọ:
(R)-(-)-3-Pyrrolidinol Hydrochloride CAS: 104706-47-0
(S) -3-Hydroxypyrrolidine hydrochloride CAS: 122536-94-1
Agbedemeji ti Panipenem (CAS 87726-17-8) ati Darifenacin hydrobromide (CAS 133099-07-7)
| Orukọ Kemikali | (R)-(-) -3-Pyrrolidinol Hydrochloride |
| Awọn itumọ ọrọ sisọ | (R)-(-) -3-Hydroxypyrrolidine Hydrochloride;(R)-(-) -3-Hydroxypyrrolidine-HCl |
| Nọmba CAS | 104706-47-0 |
| NỌMBA CAT | RF-CC102 |
| Mimọ / Analysis Ọna | ≥98.0% (GC) |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C4H10ClNO |
| Òṣuwọn Molikula | 123.58 |
| Ojuami Iyo | 107,0 ~ 111,0 °C |
| Solubility ninu Omi | Fere akoyawo |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Pa-White to Pale Brown Crystalline Powder |
| Mimọ / Analysis Ọna | ≥99.7% (GC) |
| Chiral Mimọ | ≥99.7% ee |
| Aloku lori Iginisonu | ≤0.50% |
| Yiyi pato [α]D20 | -6.5°~ -8.5° (C=3.5 CH3OH) |
| Eyikeyi Olukuluku aimọ | ≤0.20% |
| Lapapọ awọn idoti | ≤0.30% |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | Awọn agbedemeji elegbogi;Chiral Agbo |
Ọna onínọmbà
Ohun elo: Ohun elo GC (Shimadzu GC-2010)
Ọwọn: DB-17 Agilent 30mX0.53mmX1.0μm
Iwọn adiro akọkọ: 80 ℃
Akoko ibẹrẹ 2.0min
Oṣuwọn 15 ℃ / min
Iwọn adiro ikẹhin: 250 ℃
Akoko ipari 20min
Nitrogen gaasi ti ngbe
Ipo Constant sisan
Sisan 5.0ml/min
Pipin ipin 10:1
Iwọn abẹrẹ: 250 ℃
Iwọn otutu oluwari: 300 ℃
Iwọn abẹrẹ 1.0μL
Awọn iṣọra lati ṣe ṣaaju itupalẹ:
1. Ipo iwe ni 240 ℃ fun kere 30minutes.
2. Fọ syringe ati ki o mọ ikan injector daradara lati yọkuro awọn idoti ti itupalẹ iṣaaju.
3. Wẹ, gbẹ ati ki o kun diluent ni awọn agbọn fifọ syringe.
Igbaradi diluent:
Mura 2% w/v iṣuu soda hydroxide ninu omi.
Igbaradi boṣewa:
Ṣe iwọn nipa 100mg ti (R) -3-hydroxyprolidine hydrochloride boṣewa sinu vial kan, ṣafikun 1mL ti diluent ki o tu.
Igbaradi idanwo:
Ṣe iwọn nipa 100mg ti ayẹwo idanwo sinu vial kan, ṣafikun 1mL ti diluent ki o tu.Mura ni pidánpidán.
Ilana:
Abẹrẹ òfo (diluent), igbaradi boṣewa ati igbaradi idanwo ni lilo awọn ipo GC loke.Fojusi awọn oke giga nitori ofo.Akoko idaduro ti tente oke nitori (R) -3-hydroxyprolidine jẹ nipa 5.0min.
Akiyesi:
Jabọ abajade bi aropin
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ oludari ati olupese ti (R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) pẹlu didara to gaju, lilo pupọ ni iṣelọpọ Organic, iṣelọpọ ti awọn agbedemeji elegbogi ati Iṣọkan Elegbogi Ti nṣiṣe lọwọ (API).
(R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) jẹ agbedemeji deede ni iṣelọpọ ti Panipenem (CAS 87726-17-8) ati Darifenacin hydrobromide (CAS 133099-07-7).
(R)-(-) 3-Pyrrolidinol Hydrochloride (CAS: 104706-47-0) jẹ itọsẹ chiral hydroxy ti pyrrlodine ti a lo ni igbaradi ti awọn agbo ogun ti o niiṣe ti chiral gẹgẹbi awọn antagonists olugba muscarinic ati awọn aṣoju antimicrobial.
Ona ti Synthesis ti (R) -3-Hydroxypyrrolidine hydrochloride
(R) -4-chloro-3-hydroxybutanitrile ni a ṣe pẹlu trimethyl chlorosilane ni dichloromethane epo lati gba (R) -4-chloro-3-trimethylsiloxy butanitrile.(R) -4-chloro-3-trimethylsiloxyebutylamine lẹhinna hydrogenated lori Pd / C ayase.Nikẹhin, ọja (R) -3-hydroxypyrrolidine hydrochloride ni a gba nipasẹ itọju hydrochloric acid ti o ni idojukọ ati pe a ti yọ ẹgbẹ aabo trimethylsilyl kuro.
