Ramelteon (TAK-375) CAS 196597-26-9 Mimo>99.5% (HPLC)
Asiwaju Olupese ati Olupese, Intermediates ti Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-ọkan CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Ramelteon |
| Awọn itumọ ọrọ sisọ | (S) -N- [2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl) ethyl] propionamide;TAK-375;TAK375;TAK 375;Rozerem |
| Nọmba CAS | 196597-26-9 |
| NỌMBA CAT | RF2885 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
| Fọọmu Molecular | C16H21NO2 |
| Òṣuwọn Molikula | 259.35 |
| Ojuami Iyo | 113.0 si 116.0 ℃ |
| Ojuami farabale | 455,3 ± 24,0 ℃ |
| iwuwo | 1.119 ± 0,06 g / cm3 |
| Yiyi pato [α] 20/D | -55.0° si -60.0° (C=1, CHCL3) |
| Solubility ninu Omi | Ailopin ninu Omi (11 mg/l 25℃) |
| Solubility | Soluble ni Ethanol, Methanol, DMSO |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun Crystalline Powder |
| Mimọ / Analysis Ọna | > 99.5% (HPLC) |
| Ojuami Iyo | 113.0 ~ 116.0 ℃ |
| Pipadanu lori Gbigbe | <0.50% |
| Aloku lori Iginisonu | <0.10% |
| Isomer Mimọ | <0.10% |
| Awọn irin Heavy | <10ppm |
| Acidity tabi Alkalinity | Ṣe ibamu |
| Ethanol | <5000ppm |
| Aimọ Kanṣoṣo | <0.20% |
| Lapapọ Awọn Aimọ | <0.50% |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API, Afọwọsi fun Itoju ti Insomnia |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Ramelteon (CAS: 196597-26-9) ni akọkọ fọwọsi nipasẹ US Food and Drug Administration (FDA) ni Oṣu Keje ọjọ 22, ọdun 2005, lẹhinna fọwọsi nipasẹ Ile-iṣẹ elegbogi ati Ile-iṣẹ Awọn Ẹrọ Iṣoogun (PMDA) ni Oṣu Kẹrin Ọjọ 16, Ọdun 2010. O ti ni idagbasoke ati tita bi Rozerem® nipasẹ Takeda,le ṣee lo lati ṣe itọju insomnia pẹlu iṣoro sun oorun, ati pe o ni awọn ipa pataki lori insomnia onibaje ati insomnia igba diẹ.Ọja yii le mu iru 1 ṣiṣẹ ni yiyan ati tẹ awọn olugba 2 ti melatonin (MT1, MT2), pọ si oorun igbi ti o lọra (SWS) ati sisun gbigbe oju iyara (REW), nitorinaa dinku insomnia.Ramelteamide jẹ oogun itọju insomnia akọkọ ti kii ṣe afẹsodi ti ko si labẹ iṣakoso pataki.Ọja yii jẹ agonist olugba olugba melatonin.O ni ibatan giga pẹlu melatonin MT1 ati awọn olugba MT2, ati pe o ni ipa agonistic kan pato ati pipe lori awọn olugba MT1 ati MT2, ṣugbọn ko ṣe ajọṣepọ pẹlu olugba MT3.Ni afikun, ko sopọ mọ awọn olugba neurotransmitter gẹgẹbi awọn eka olugba GABA, ati pe ko dabaru pẹlu iṣẹ ṣiṣe ti ọpọlọpọ awọn enzymu laarin iwọn kan.Nitorina, o le yago fun idamu ti o ni nkan ṣe pẹlu awọn oogun GABA (eyiti o le fa awọn ijamba ọkọ ayọkẹlẹ, ṣubu ati awọn fifọ).Ati bẹbẹ lọ) ati afẹsodi oogun ati igbẹkẹle.Rozerem® wa bi tabulẹti ti a bo fiimu fun lilo ẹnu, ti o ni 8 miligiramu ti Ramelteon ọfẹ ninu.Iwọn agbalagba ti a ṣe iṣeduro jẹ 8 miligiramu ti o mu laarin awọn iṣẹju 30 ti lilọ si ibusun.
