Ramelteon Intermediate 12 CAS 1053239-39-6 Mimọ>98.0% (HPLC)

Apejuwe kukuru:

Orukọ Kemikali: 2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride

Awọn itumọ ọrọ sisọ: Ramelteon Intermediate 12

CAS: 1053239-39-6

Mimọ:> 98.0% (HPLC)

Irisi: Funfun si Paa-White Ri to Powder

Agbedemeji ti Ramelteon (CAS: 196597-26-9)

Olubasọrọ: Dokita Alvin Huang

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E-Mail: alvin@ruifuchem.com


Alaye ọja

Jẹmọ Products

ọja Tags

Apejuwe:

Kemikali Properties:

Orukọ Kemikali 2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride
Awọn itumọ ọrọ sisọ Ramelteon Intermediate 12;Ipele Ramelteon-2 Aimọ;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride
Nọmba CAS 1053239-39-6
NỌMBA CAT RF2887
Iṣura Ipo Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu
Fọọmu Molecular C13H18ClNO
Òṣuwọn Molikula 239.74
Ojuami Iyo 165.0 ~ 167.0 ℃
iwuwo 1,058 ± 0,06 g / cm3
Brand Ruifu Kemikali

Awọn pato:

Nkan Awọn pato
Ifarahan Funfun to Pa-White ri to Powder
Mimọ / Analysis Ọna > 98.0% (HPLC)
Pipadanu lori Gbigbe <1.00%
Aimọ Kanṣoṣo <1.00%
Lapapọ Awọn Aimọ <2.00%
1 H NMR julọ.Oniranran Ni ibamu Pẹlu Be
Igbeyewo Standard Standard Enterprise
Lilo Agbedemeji ti Ramelteon (CAS: 196597-26-9)

Package & Ibi ipamọ:

Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin

Awọn anfani:

Agbara to to: Awọn ohun elo to ati awọn onimọ-ẹrọ

Iṣẹ Ọjọgbọn: Iṣẹ rira iduro kan

OEM Package: Aṣa package ati aami wa

Ifijiṣẹ Yara: Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta

Ipese Idurosinsin: Ṣetọju ọja iṣura ti o tọ

Atilẹyin imọ-ẹrọ: Ojutu imọ-ẹrọ wa

Iṣẹ Iṣọkan Aṣa: Larin lati giramu si kilos

Didara to gaju: Ṣeto eto idaniloju didara pipe

FAQ:

Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com 

15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.

Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.

Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.

DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl

Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.

Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.

MOQ?Ko si MOQ.Ibere ​​kekere jẹ itẹwọgba.

Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.

Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.

Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.

Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.

Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.

Ohun elo:

2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) jẹ agbedemeji ti Ramelteon (CAS: 196597- 26-9).Ko dabi ọpọlọpọ awọn itọju ti insomnia ti o fojusi eka olugba GABA (g-aminobutyric acid), Ramelteon jẹ agonist ti olugba melatonin.Ni pataki, o ni yiyan giga fun awọn oriṣi MT1 ati MT2, eyiti o ti ni ipa ninu itọju awọn rhythmu ti circadian, lori olugba MT3 ti o ni iduro fun awọn iṣẹ melatonin miiran.Aini isunmọ rẹ fun kii ṣe eka olugba GABA nikan ṣugbọn tun neurotransmitter, dopaminerigic, opiate, ati awọn olugba benzodiazepine ni imọran profaili ailewu ti ilọsiwaju laisi agbara ilokulo ti awọn oogun hypnotic ti o fojusi awọn olugba wọnyi.Bii iru bẹẹ, Ramelteon kii ṣe oogun ti a ṣeto.Awọn iṣelọpọ akọkọ pẹlu hydroxylation ati oxidation si eya carbonyl pẹlu awọn metabolites keji ti o waye lati glucuronidation.Niwọn igba ti CYP1A2 jẹ isozyme pataki ti o ni ipa ninu iṣelọpọ ẹdọ ti Ramelteon, ko yẹ ki o mu ni apapo pẹlu awọn inhibitors CYP1A2 ti o lagbara, gẹgẹbi fluvoxamine.Ijọṣepọ pẹlu boya ketoconazole (inhibitor CYP3A4) tabi fluconazole (oludaniloju CYP2C9 ti o lagbara) yorisi awọn ilọsiwaju pataki ni AUC ati Cmax, ṣugbọn iṣelọpọ agbara ati awọn ifọkansi pilasima iyipada pupọ ti Ramelteon ṣe idiwọ iwulo fun iyipada iwọn lilo.Awọn ifibọ package, sibẹsibẹ, kilọ fun awọn alaisan nipa iṣakojọpọ pẹlu agbara CYP3A4 ati awọn inhibitors CYP2C9.Da lori abajade ti awọn idanwo ile-iwosan, iwọn lilo iṣeduro ti Ramelteon jẹ 8mg ti a mu laarin awọn iṣẹju 30 ti lilọ si ibusun.Ni afikun si iṣọra ti iṣakoso iṣọpọ pẹlu awọn inhibitors CYP, ko yẹ ki o lo ni awọn alaisan ti o ni ailagbara ẹdọforo nla.Awọn iṣẹlẹ buburu, ti a ṣe akiyesi ni 5% ti awọn alaisan ni awọn ẹkọ iwosan, jẹ irọra, dizziness, ọgbun, rirẹ, orififo, ati insomnia.

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