Ramelteon Intermediate 12 CAS 1053239-39-6 Mimọ>98.0% (HPLC)
Asiwaju Olupese ati Olupese, Intermediates ti Ramelteon
Ramelteon (TAK-375) CAS 196597-26-9
2,3-Dihydrobenzofuran CAS 496-16-2
1,2,6,7-Tetrahydro-8H-Indeno[5,4-b]furan-8-ọkan CAS 196597-78-1
Ramelteon Acrylonitrile CAS 196597-79-2
Despropionyl Ramelteon Hydrochloride CAS 196597-80-5
2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride CAS 1053239-39-6
Please contact: alvin@ruifuchem.com
Orukọ Kemikali | 2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl)ethanamine Hydrochloride |
Awọn itumọ ọrọ sisọ | Ramelteon Intermediate 12;Ipele Ramelteon-2 Aimọ;1,6,7,8-Tetrahydro-2H-Indeno[5,4-B]Furan-8-Ethanamine Hydrochloride |
Nọmba CAS | 1053239-39-6 |
NỌMBA CAT | RF2887 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C13H18ClNO |
Òṣuwọn Molikula | 239.74 |
Ojuami Iyo | 165.0 ~ 167.0 ℃ |
iwuwo | 1,058 ± 0,06 g / cm3 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun to Pa-White ri to Powder |
Mimọ / Analysis Ọna | > 98.0% (HPLC) |
Pipadanu lori Gbigbe | <1.00% |
Aimọ Kanṣoṣo | <1.00% |
Lapapọ Awọn Aimọ | <2.00% |
1 H NMR julọ.Oniranran | Ni ibamu Pẹlu Be |
Igbeyewo Standard | Standard Enterprise |
Lilo | Agbedemeji ti Ramelteon (CAS: 196597-26-9) |
Package: Igo, apo bankanje aluminiomu, 25kg / Paali ilu, tabi gẹgẹ bi ibeere alabara
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
2- (2,6,7,8-Tetrahydro-1H-Indeno [5,4-b]furan-8-yl) ethanamine Hydrochloride (CAS: 1053239-39-6) jẹ agbedemeji ti Ramelteon (CAS: 196597- 26-9).Ko dabi ọpọlọpọ awọn itọju ti insomnia ti o fojusi eka olugba GABA (g-aminobutyric acid), Ramelteon jẹ agonist ti olugba melatonin.Ni pataki, o ni yiyan giga fun awọn oriṣi MT1 ati MT2, eyiti o ti ni ipa ninu itọju awọn rhythmu ti circadian, lori olugba MT3 ti o ni iduro fun awọn iṣẹ melatonin miiran.Aini isunmọ rẹ fun kii ṣe eka olugba GABA nikan ṣugbọn tun neurotransmitter, dopaminerigic, opiate, ati awọn olugba benzodiazepine ni imọran profaili ailewu ti ilọsiwaju laisi agbara ilokulo ti awọn oogun hypnotic ti o fojusi awọn olugba wọnyi.Bii iru bẹẹ, Ramelteon kii ṣe oogun ti a ṣeto.Awọn iṣelọpọ akọkọ pẹlu hydroxylation ati oxidation si eya carbonyl pẹlu awọn metabolites keji ti o waye lati glucuronidation.Niwọn igba ti CYP1A2 jẹ isozyme pataki ti o ni ipa ninu iṣelọpọ ẹdọ ti Ramelteon, ko yẹ ki o mu ni apapo pẹlu awọn inhibitors CYP1A2 ti o lagbara, gẹgẹbi fluvoxamine.Ijọṣepọ pẹlu boya ketoconazole (inhibitor CYP3A4) tabi fluconazole (oludaniloju CYP2C9 ti o lagbara) yorisi awọn ilọsiwaju pataki ni AUC ati Cmax, ṣugbọn iṣelọpọ agbara ati awọn ifọkansi pilasima iyipada pupọ ti Ramelteon ṣe idiwọ iwulo fun iyipada iwọn lilo.Awọn ifibọ package, sibẹsibẹ, kilọ fun awọn alaisan nipa iṣakojọpọ pẹlu agbara CYP3A4 ati awọn inhibitors CYP2C9.Da lori abajade ti awọn idanwo ile-iwosan, iwọn lilo iṣeduro ti Ramelteon jẹ 8mg ti a mu laarin awọn iṣẹju 30 ti lilọ si ibusun.Ni afikun si iṣọra ti iṣakoso iṣọpọ pẹlu awọn inhibitors CYP, ko yẹ ki o lo ni awọn alaisan ti o ni ailagbara ẹdọforo nla.Awọn iṣẹlẹ buburu, ti a ṣe akiyesi ni 5% ti awọn alaisan ni awọn ẹkọ iwosan, jẹ irọra, dizziness, ọgbun, rirẹ, orififo, ati insomnia.