(S) -1-Boc-3-Hydroxypiperidine CAS 143900-44-1 Ibrutinib Agbedemeji Mimọ>99.0% (GC)
Orukọ Kemikali | (S) -1-Boc-3-Hydroxypiperidine |
Awọn itumọ ọrọ sisọ | (S) -1- (tert-Butoxycarbonyl) -3-Hydroxypiperidine;(S) -1-Boc-3-Piperidinol |
Nọmba CAS | 143900-44-1 |
NỌMBA CAT | RF-CC299 |
Iṣura Ipo | Ni Iṣura, Agbara iṣelọpọ 20 Tons / osù |
Fọọmu Molecular | C10H19NO3 |
Òṣuwọn Molikula | 201.27 |
Ojuami Iyo | 52.0 ~ 56.0 ℃ |
Solubility | Tiotuka ni kẹmika |
Yiyi pato [a] 20/D | +9.0°~+11.0° (C=1 ninu Chloroform) |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun Powder tabi kirisita |
Chiral Mimọ | > 99.5% (GC) |
Kẹmika ti nw | > 99.5% (GC) |
Omi (KF) | ≤0.50% |
Methanol (GC) | ≤50ppm |
Ethanol (GC) | ≤50ppm |
DCM (GC) | ≤500ppm |
3-Hydroxypiperidine | ≤0.10% |
3-Hydroxypyridine | ≤0.20% |
1-Boc-3-Piperidone | ≤0.10% |
1-Boc-4-Hydroxypiperidine | ≤0.10% |
1,96 RRT | ≤0.20% |
Eyikeyi Aisọye Aimọ | ≤0.10% |
Igbeyewo Standard | Standard Enterprise |
Lilo | Awọn agbedemeji elegbogi;Chiral Agbo |
Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.
(S) -1-Boc-3-Hydroxypiperidine (CAS: 143900-44-1) jẹ agbedemeji chiral pataki fun iṣelọpọ ti Ibrutinib (CAS: 936563-96-1).Ibrutinib jẹ iru ti Bruton tyrosine kinase (BTK) onidalẹkun, o le ṣee lo fun awọn itọju ti onibaje lymphocytic aisan lukimia (CLL) ati mantle cell lymphoma (MCL).MCL ati CLL jẹ ti sẹẹli B-cell ti kii-Hodgkin's lymphoma, eyiti o nira lati ṣe iwosan ati rọrun lati loorekoore.Ajẹsara kemikali ti o wọpọ ko ni ibi-afẹde, nigbagbogbo waye 3 tabi 4 awọn aati ikolu.Ibrutinib ati B lymphocytes le ṣe ifọkansi pẹlu BTK eyiti o jẹ dandan fun dida, iyatọ, ati gbigbe alaye, ṣe idiwọ iṣẹ BTK ni aibikita, ati ṣe idiwọ itankale sẹẹli tumo ati iwalaaye daradara.Ibrutinib le gba ni kiakia lẹhin iṣakoso ẹnu, lakoko 1 ~ 2h de ọdọ ifọkansi ẹjẹ ti o pọju, awọn aati ikolu jẹ ti ọkan tabi meji, nitorinaa, Ibrutinib yoo di yiyan ti itọju CLL ati MCL tuntun.