Sorafenib CAS 284461-73-0 Mimọ ≥99.0% (HPLC) API Didara Giga Factory
Ipese Iṣowo Sorafenib Tosylate ati Awọn agbedemeji ti o jọmọ:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4- (4-Aminophenoxy) -N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3- (Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Oruko | Sorafenib |
| Awọn itumọ ọrọ sisọ | Sorafenib Free Mimọ |
| Nọmba CAS | 284461-73-0 |
| NỌMBA CAT | RF-API04 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
| Fọọmu Molecular | C21H16ClF3N4O3 |
| Òṣuwọn Molikula | 464.82 |
| iwuwo | 1,454 ± 0,06 g / cm3 |
| Solubility | Tiotuka ni DMSO |
| Awọn ipo gbigbe | Ibaramu otutu |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun to Pa-White Powder |
| Mimọ / Analysis Ọna | ≥99.0% (HPLC) |
| Idanimọ | H-NMR, MS |
| Pipadanu lori Gbigbe | ≤1.0% |
| Aloku lori Iginisonu | ≤0.10% |
| Aimọ Kanṣoṣo | ≤0.20% (HPLC) |
| Lapapọ Awọn Aimọ | ≤1.0% (HPLC) |
| Awọn irin Heavy | ≤20ppm |
| wípé Solusan | Ni ibamu si Standard |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | RCC & HCC |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Sorafenib Tosylate (CAS: 475207-59-1) jẹ iru tuntun ti oogun antitumor olona-fojusi, ti ni idagbasoke nipasẹ German Bayer Pharmaceuticals, o si ṣe afihan iṣẹ-ṣiṣe antitumor ti o gbooro ni awọn idanwo ẹranko preclinical.Sorafenib wa ninu awọn tabulẹti 200-mg fun iṣakoso ẹnu ati pe a lo ninu itọju RCC ati HCC.Sorafenib Tosylate (CAS: 475207-59-1) le ni ipa nigbakanna awọn sẹẹli tumo ati awọn ohun elo ẹjẹ tumo.O ni ipa antitumor ilọpo meji: o le ṣe idiwọ awọn ipa ọna gbigbe ifihan sẹẹli ti o ni ilaja nipasẹ RAF/MEK/ERK lati ṣe idiwọ idagbasoke sẹẹli tumo taara, lakoko ti o tun ṣe idiwọ VEGF ati awọn awọn olugba idagbasoke ti platelet (PDGF) lati ṣe idiwọ dida ti ẹjẹ tumo tuntun. awọn ohun elo, nitorina ni aiṣe-taara ṣe idiwọ idagbasoke sẹẹli tumo.Sorafenib jẹ onidalẹkun ti Raf-1 ati B-RAF bii ọpọlọpọ awọn kinases tyrosine.
