Sorafenib Tosylate CAS 475207-59-1 Mimọ ≥99.0% (HPLC) API Didara Giga Factory
Ipese Iṣowo Sorafenib Tosylate ati Awọn agbedemeji ti o jọmọ:
Sorafenib Tosylate CAS: 475207-59-1
Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4- (4-Aminophenoxy) -N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3- (Trifluoromethyl) phenyl Isocyanate CAS: 327-78-6
| Orukọ Kemikali | Sorafenib Tosylate |
| Awọn itumọ ọrọ sisọ | Nexavar;4- [4-[3-[4-Chloro-3- (Trifluoromethyl) phenyl] ureido] phenoxy] -N-Methylpicolinamide 4-Methylbenzenesulfonate;4- [4-[[4-Chloro-3- (Trifluoromethyl) phenyl] carbamamido] phenoxy] -N-Methyl-2-Pyridinecarboxamide 4-Methylbenzenesulfonate;BAY 43-9006 Tosylate |
| Nọmba CAS | 475207-59-1 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
| Fọọmu Molecular | C21H16ClF3N4O3.C7H8O3S |
| Òṣuwọn Molikula | 637.03 |
| Ojuami Iyo | 225.0 si 230.0 ℃ |
| Ni imọlara | Afẹfẹ Sensitive, Ooru kókó |
| Solubility | Tiotuka ninu Omi (<1 mg / ml) ni 25 ℃, DMSO (127 mg / ml) ni 25 ℃, ati Ethanol (<1 mg / ml) ni 25 ℃ |
| Awọn ipo gbigbe | Itura & Gbe (2 ~ 8 ℃), Dabobo lati Imọlẹ |
| COA & MSDS | Wa |
| Igbesi aye selifu | Awọn ọdun 2 ti o ba fipamọ daradara |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato | Esi |
| Ifarahan | Ina Yellow tabi Funfun Powder | Ibamu |
| Mimọ / Analysis Ọna | ≥99.0% (HPLC) | 99.8% |
| Ojuami Iyo | 225.0 ~ 230.0 ℃ | Ibamu |
| Awọn irin Heavy | ≤10ppm | <10ppm |
| Pipadanu lori Gbigbe | ≤0.50% | 0.12% |
| Aloku lori Iginisonu | ≤0.20% | 0.10% |
| Eyikeyi Nikan Aimọ | ≤0.50% | Ibamu |
| Lapapọ Awọn Aimọ | ≤0.50% | Ibamu |
| NMR julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Igbeyewo Standard | Standard Enterprise | Ibamu |
| Lilo | Sorafenib Tosylate (CAS: 475207-59-1) ni itọju RCC & HCC | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Tọju ni wiwọ titi eiyan.Fipamọ sinu itura, gbigbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Awọn koodu Ewu 36/37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Aabo S28 - Lẹhin olubasọrọ pẹlu awọ ara, wẹ lẹsẹkẹsẹ pẹlu ọpọlọpọ ọṣẹ-suds.
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
Sorafenib Tosylate (CAS: 475207-59-1) jẹ iru tuntun ti oogun antitumor olona-fojusi, ti ni idagbasoke nipasẹ German Bayer Pharmaceuticals, o si ṣe afihan iṣẹ-ṣiṣe antitumor ti o gbooro ni awọn idanwo ẹranko preclinical.Sorafenib wa ninu awọn tabulẹti 200-mg fun iṣakoso ẹnu ati pe a lo ninu itọju RCC ati HCC.Sorafenib Tosylate le ni ipa nigbakanna awọn sẹẹli tumo ati awọn ohun elo ẹjẹ tumo.O ni ipa antitumor ilọpo meji: o le ṣe idiwọ awọn ipa ọna gbigbe ifihan sẹẹli ti o ni ilaja nipasẹ RAF/MEK/ERK lati ṣe idiwọ idagbasoke sẹẹli tumo taara, lakoko ti o tun ṣe idiwọ VEGF ati awọn awọn olugba idagbasoke ti platelet (PDGF) lati ṣe idiwọ dida ti ẹjẹ tumo tuntun. awọn ohun elo, nitorina ni aiṣe-taara ṣe idiwọ idagbasoke sẹẹli tumo.
Sorafenib Tosylate, orukọ iṣowo Nexavar, akọkọ ni idagbasoke nipasẹ Bayer Pharmaceuticals ni Germany.Sorafenib Tosylate jẹ inhibitor multi-kinase ti o le ṣee lo lati tọju awọn arun bii akàn.Ni Oṣu Kejila ọdun 2005, FDA AMẸRIKA fọwọsi rẹ gẹgẹbi oogun laini akọkọ fun itọju ti akàn kidirin to ti ni ilọsiwaju.Ni Oṣu Kẹjọ ọdun 2009, a ṣe atokọ ni ifowosi ni Ilu China pẹlu ifọwọsi ti Ipinle Ounje ati Oògùn.
Sorafenib Tosylate jẹ awọn kinases tyrosine (VEGFR ati PDGFR) ati RAF/MEK/ERK kascade inhibitors, ti n ṣiṣẹ ni nigbakannaa lori Raf-1,wtBRAF ati V599EBRAF, pẹlu IC50 ti 6 nM, 22 nM ati 38 nM, lẹsẹsẹ.
Sorafenib Tosylate le ṣe idiwọ ni igbakanna awọn oriṣiriṣi awọn kinases ti o wa lori sẹẹli ati oju-ara sẹẹli, pẹlu RAF kinase, ti iṣan-ẹjẹ ti iṣan ti iṣan ti iṣan-2 (VEGFR-2), ti iṣan ti iṣan ti iṣan-3 (VEGFR-3), platelet. -ti ari idagba ifosiwewe receptor-β (PDGFR-β), KIT ati FLT-3.O le rii pe sorafenib toluenesulfonate ni awọn ipa ipakokoro-egbo meji.Ni ọna kan, o le ṣe idiwọ idagbasoke tumo taara nipasẹ didi ọna ami ifihan RAF / MEK / ERK;ni apa keji, o le ṣe idiwọ VEGFR ati PDGFR.Ki o si dènà awọn Ibiyi ti tumo neovascularization, fi ogbon ekoro dojuti awọn idagba ti tumo ẹyin.Sorafenib Tosylate jẹ oogun ti o munadoko julọ fun itọju ti akàn ẹdọ ti nlọsiwaju nipasẹ iṣakoso eto, ati pe yoo ṣee di oogun tuntun tuntun fun itọju arun yii.
Sorafenib Tosylate lẹẹkan lojoojumọ iṣakoso ẹnu ti awọn awoṣe gbigbe ẹran tumo eniyan ṣe afihan ọpọlọpọ iṣẹ ṣiṣe egboogi-tumor, pẹlu akàn oluṣafihan, carcinoma sẹẹli ti kii-kekere, aarun igbaya, melanoma, akàn pancreatic, lukimia ati akàn ọjẹ ati carcinoma kidirin eku awoṣe, RENCA awoṣe.
