Tacrolimus FK-506 Fujimycin CAS 104987-11-3 API Ile-iṣẹ mimọ giga
Olupese pẹlu Giga ti nw ati Idurosinsin Didara
Orukọ Kemikali: Tacrolimus
Awọn itumọ ọrọ-ọrọ: FK-506;Fujimycin
CAS: 104987-11-3
API, Didara Giga, Ṣiṣejade Iṣowo
Orukọ Kemikali | Tacrolimus |
Awọn itumọ ọrọ sisọ | FK-506;Fujimycin |
Nọmba CAS | 104987-11-3 |
NỌMBA CAT | RF-API46 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C44H69NO12 |
Òṣuwọn Molikula | 804.02 |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Pa-White tabi Biayẹ Yellow Fine Powder, Odourless, Special Dun Lenu |
Idanimọ | Yẹ ki o jẹ Idahun rere |
wípé | Ni ibamu pẹlu Standard |
pH | 5.0 ~ 6.0 |
Kloride | ≤0.014% |
Sulfate | ≤0.029% |
Awọn Irin Eru (Pb) | ≤10ppm |
Arsenic | ≤0.0002% |
Ọrinrin (KF) | ≤8.0% |
Aloku lori Iginisonu | 18.0% ~ 22.0% |
Ayẹwo | ≥72.0% (HPLC, lori ipilẹ ti o gbẹ) |
Igbeyewo Standard | Standard Enterprise |
Lilo | API |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
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Tacrolimus (bakannaa FK-506 tabi Fujimycin) jẹ oogun ajẹsara ajẹsara ti lilo akọkọ jẹ lẹhin gbigbe ara eniyan lati dinku iṣẹ ṣiṣe ti eto ajẹsara alaisan ati nitorinaa eewu ti ijusile ara eniyan.O tun lo ni igbaradi ti agbegbe ni itọju ti atopic dermatitis ti o lagbara, uveitis refractory ti o lagbara lẹhin awọn gbigbe ti ọra inu egungun, ati ipo awọ ara vitiligo.Tacrolimus ni akọkọ jade lati inu omitooro bakteria ti Streptomyces tsukuba, microbe ile kan ti a rii ni Tsukuba, Japan.Orukọ tacrolimus wa nipasẹ gbigbe 't' fun Tsukuba, orukọ oke nibiti a ti fa ayẹwo ile, 'acrol' fun macrolide ati 'imus' fun ajẹsara.Botilẹjẹpe igbekale ti ko ni ibatan si cyclosporin, tacrolimus ṣe afihan iru irisi ti awọn ipa ajẹsara si aṣoju yii ni ipele cellular ati molikula.Awọn ijinlẹ akọkọ fihan pe tacrolimus jẹ ajẹsara ti o lagbara, ti o nfihan isunmọ 100-agbo ti o tobi ju ni vitro agbara ju cyclosporin ni idinamọ imuṣiṣẹ sẹẹli T.Awọn ijinlẹ vivo ti o tẹle ti fihan tacrolimus lati munadoko mejeeji ni didapa lẹẹkọkan ati aarun autoimmune esiperimenta, ati ni idilọwọ allograft ati ijusile xenograft ni awọn awoṣe ẹranko ti gbigbe ara eniyan.Ni akọkọ, a lo tacrolimus fun imunosuppress eto eto ti awọn alaisan ti o ti ṣe awọn asopo ohun elo lati da wọn duro lati kọ awọn alọmọ tuntun wọn.Laipẹ, sibẹsibẹ, nipasẹ anfani ti serendipity ti imọ-jinlẹ, a ṣe akiyesi pe tacrolimus le ṣe awọn abajade to dara ni awọn rudurudu awọ ara ni diẹ ninu awọn alaisan ti o ti ṣe itọlẹ.Iwari ti tacrolimus ti ni bayi yorisi oye ti o tobi ju ti ẹkọ nipa awọ ara, fun apẹẹrẹ ti atopic dermatitis.Lẹhinna, awọn ohun elo agbegbe miiran ti tacrolimus ni a royin ati lilo aṣoju yii ni imọ-ara ti n pọ si ni diėdiė.
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