Tenofovir Alafenamide Hemifumarate TAF CAS 1392275-56-7 API Factory Anti-HIV Didara Giga
Ipese Iṣowo Tenofovir Awọn agbedemeji ibatan:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl) phosphonate CAS 31618-90-3
(R)-(+) -Propylene Carbonate CAS 16606-55-6
(R) -9- (2-Hydroxypropyl) adenine CAS 14047-28-0
Diethyl (Hydroxymethyl) phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
Orukọ Kemikali | Tenofovir Alafenamide Hemifumarate |
Awọn itumọ ọrọ sisọ | TAF;GS-7340 Hemifumarate |
Nọmba CAS | 1392275-56-7 |
NỌMBA CAT | RF-API91 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
Fọọmu Molecular | C25H33N6O9P |
Òṣuwọn Molikula | 592.55 |
Ibi ipamọ otutu | Ididi ni Gbẹ, Yara otutu |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun si Fere White kirisita tabi Crystalline Powder |
Solubility | Soluble ni Dimethylformamide, ati Methanol;Sparingly Soluble ni Omi ati THF;Tiotuka die-die ni Acetonitrile ati Insoluble ni Dichloromethane ati Toluene |
Idanimọ A | Awọn iwoye gbigba IR yẹ ki o wa ni ibamu pẹlu itọkasi |
Idanimọ B | Akoko idaduro ti oke pataki ti ojutu ayẹwo ni ipinnu akoonu chromatogram ṣe ibamu si ti ojutu itọkasi |
Idanimọ C | Akoko idaduro Fumaric Acid ti oke pataki ninu ipinnu akoonu chromatogram ṣe ibamu si tente oke ti itọkasi |
Akoonu Omi (nipasẹ KF) | ≤1.0% |
wípé Solusan | Ni ipilẹ ko si awọn patikulu ti o han ni 2% (w/v) ti alaye Methanol Solusan |
Aloku ti o ku | |
Acetonitrile | ≤410ppm |
Ethanol | ≤5000ppm |
Dichloromethane | ≤600ppm |
Toluene | ≤890ppm |
Aloku lori Iginisonu | ≤0.10% |
Awọn irin Heavy | ≤20ppm |
Awọn nkan ti o jọmọ | |
PMPA | ≤1.0% |
PMPA Anhydride | ≤0.75% |
Phenyl PMPA nikan | ≤1.0% |
Eyikeyi Aisọye Aimọ | ≤0.15% |
Lapapọ Awọn Aimọ | ≤2.0% |
Isomer | ≤1.0% |
Akoonu ti Fumaric Acid | 9.0% ~ 13.0% (lori ipilẹ anhydrous) |
Makirobia ifilelẹ | |
Lapapọ Aerobic makirobia kika | ≤1000CFU/g |
Apapọ iwukara ati Molds Ka | ≤100CFU/g |
Escherichia Coli | Ti ko si |
Ayẹwo | 98.0% ~ 102.0% (lori ipilẹ anhydrous ati ti ko ni epo) |
Igbeyewo Standard | Standard Enterprise |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin ati kokoro infestation.
Tenofovir Alafenamide Hemifumarate (TAF, GS-7340 hemifumarate), CAS 1392275-56-7, jẹ nucleotide reverse transcriptase inhibitor (NRTIs) ati prodrug aramada ti Tenofovir (TFV).Nipa didi iyipada transcriptase, TAF ṣe idiwọ HIV lati isodipupo ati pe o le dinku iye HIV ninu ara.Tenofovir alafenamide jẹ oogun oogun, eyiti o tumọ si pe o jẹ oogun ti ko ṣiṣẹ.Ninu ara, tenofovir alafenamide ti yipada si Tenofovir diphosphate (TFV-DP).Tenofovir Alafenamide Fumarate ti fọwọsi ni Oṣu kọkanla ọdun 2015 fun itọju HIV-1.