Tenofovir Disoproxil Fumarate CAS 202138-50-9 Assay 98.0%~102.0% API Factory
Ipese Iṣowo Tenofovir Awọn agbedemeji ibatan:
Tenofovir CAS: 147127-20-6
Tenofovir Disoproxil Fumarate CAS 202138-50-9
Tenofovir Alafenamide Hemifumarate CAS 1392275-56-7
Chloromethyl isopropyl Carbonate CAS 35180-01-9
Diethyl (p-Toluenesulfonyloxymethyl) phosphonate CAS 31618-90-3
(R)-(+) -Propylene Carbonate CAS 16606-55-6
(R) -9- (2-Hydroxypropyl) adenine CAS 14047-28-0
Diethyl (Hydroxymethyl) phosphonate CAS 3084-40-0
Adenine CAS 73-24-5
Orukọ Kemikali | Tenofovir Disoproxil Fumarate |
Awọn itumọ ọrọ sisọ | Tenofovir DF;Bis (POC) -PMPA Fumarate;GS 4331 Fumarate |
Nọmba CAS | 202138-50-9 |
NỌMBA CAT | RF-API106 |
Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn Toonu |
Fọọmu Molecular | C23H34N5O14P |
Òṣuwọn Molikula | 635.52 |
Ojuami Iyo | 113.0 si 115.0 ℃ |
Brand | Ruifu Kemikali |
Nkan | Awọn pato |
Ifarahan | Funfun tabi Fere Funfun Powder |
Idanimọ A | IR julọ.Oniranran ni ibamu si Standard Reference |
Idanimọ B | Akoko idaduro ti tente oke pataki lati ojutu ayẹwo ni ibamu si ti ojutu iduro, bi a ti gba ninu idanwo naa |
Ayẹwo | 98.0% ~ 102.0% (lori ipilẹ anhydrous) |
Omi | ≤1.0% |
Fumaric Acid | 17.5% ~ 19.0% |
Aloku lori Iginisonu | ≤0.20% |
Awọn irin Heavy | ≤20ppm |
Chloromethyl isopropyl Carbonate | ≤0.15% |
Awọn nkan ti o jọmọ | |
Tenofovir | ≤0.15% |
Adenine | ≤0.15% |
Tenofovir Isoproxi Monoester | ≤1.0% |
Tenofovir Disoproxil Ethyl Ester | ≤0.15% |
Tenofovir Isopropyl Isoproxil | ≤0.30% |
Tenofovir Disoproxil Carbamate | ≤0.15% |
Tenofovir Disproxil | ≤0.15% |
Eyikeyi Nikan Aimọ | ≤0.10% |
Lapapọ Awọn Aimọ | ≤2.0% |
Igbeyewo Standard | Standard Enterprise |
Lilo | API |
Package: Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.
Tenofovir Disoproxil Fumarate (CAS: 202138-50-9), prodrug ti tenofovir (Orukọ Iṣowo: Viread) ti o dagbasoke nipasẹ Awọn sáyẹnsì Gileadi, jẹ iru awọn oogun antiretroviral ti nucleotide-analogues, ti o ni ipa nipasẹ ṣiṣe bi awọn inhibitors transcriptase yiyipada[nRTIs] , eyiti o ṣe idiwọ iyipada transcriptase, enzymu pataki si iṣelọpọ gbogun ti ni awọn eniyan ti o ni kokoro-arun HIV.O yẹ ki o ṣe akiyesi pe o jẹ onidalẹkun transcriptase akọkọ ti nucleotide ti o ti lo fun itọju ikolu HIV.Tenofovir Disoproxil Fumarate ti yipada si tenofovir ni vivo, eyiti o jẹ acyclic nucleoside phosphonate[nucleotide] afọwọṣe ti adenosine 5'-monophosphate.O ti wa ni gbogbo lo ni apapo pẹlu miiran iru oogun.Awọn oogun HIV ko le ṣe iwosan HIV/AIDS, ṣugbọn gbigba apapo awọn oogun HIV[ti a npe ni ilana HIV] lojoojumọ le ṣe iranlọwọ fun awọn eniyan ti o ni kokoro HIV ni igbesi aye gigun, igbesi aye ilera.Da lori iwe FDA, tenofovir disoproxil fumarate tun le jẹ fun itọju ti arun jedojedo B onibaje [HBV] ninu awọn agbalagba ati awọn ọmọde ọdun 12 ati agbalagba.