Tranexamic Acid CAS 1197-18-8 Assay 99.0~101.0% (Titration)
Shanghai Ruifu Kemikali Co., Ltd jẹ olupilẹṣẹ asiwaju ti Tranexamic Acid (CAS: 1197-18-8) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Tranexamic Acid,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Tranexamic Acid |
| Awọn itumọ ọrọ sisọ | trans-4- (Aminomethyl) cyclohexanecarboxylic Acid;Acid trans-Tranecsamic;TAMCHA;AMCHA;HAKU;AMCA;t-AMCHA;trans-Amcha |
| Iṣura Ipo | Ni Iṣura, Iṣowo Iṣowo |
| Nọmba CAS | 1197-18-8 |
| Fọọmu Molecular | C8H15NO2 |
| Òṣuwọn Molikula | 157,21 g / mol |
| Ojuami Iyo | > 300 ℃ (tan.) |
| Iduroṣinṣin | Hygroscopic |
| Omi Solubility | Tiotuka ninu Omi, Fere akoyawo |
| COA & MSDS | Wa |
| Apeere Ọfẹ | Wa |
| Ipilẹṣẹ | Shanghai, China |
| Brand | Ruifu Kemikali |
| Awọn nkan | Awọn pato | Esi |
| Ifarahan | Funfun Crystalline Powder | Ibamu |
| Solubility | Tiotuka ninu Omi ati Acetic Acid Glacial, Fere Ko Tiotuka ninu Ethanol ati Acetone (96%) | Ibamu |
| IR julọ.Oniranran | Ni Concordance pẹlu Tranexamic Acid CRS | Ibamu |
| pH | 7.0 ~ 8.0 | 7.32 |
| Pipadanu lori Gbigbe | <0.50% | 0.06% |
| Eru Sulfate | <0.10% | 0.02% |
| Awọn Irin Eru (Pb) | ≤10ppm | <10ppm |
| Kloride (Cl) | ≤140ppm | <140ppm |
| Arsenic (Bi) | ≤2ppm | <2ppm |
| Ayẹwo | 99.0 ~ 101.0% (nipasẹ Titration) | 99.84% |
| Awọn nkan ti o jọmọ | ||
| Aimọ́ A | <0.10% | 0% |
| Aimọ́ B | <0.20% | 0.0815% |
| Iwa aimọ C | <0.10% | 0.0089% |
| Àìmọ́ D | <0.10% | 0.0063% |
| Lapapọ Awọn Aimọ | <0.20% (ayafi A, B) | 0.015% |
| Ipari | Ọja naa ti ni idanwo ati ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo Fluorinated, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Jeki apo eiyan naa ni wiwọ ni pipade ati tọju ni itura, gbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
Tranexamic Acid
C8H15NO2 157.2
trans-4- (Aminomethyl) cyclohexanecarboxylic acid;
Cyclohexanecarboxylic acid, 4- (aminomethyl) -, trans [1197-18-8].
ITUMO
Tranexamic Acid ni NLT 99.0% ati NMT 101.0% ti C8H15NO2, ṣe iṣiro lori ipilẹ gbigbe.
Ìdámọ̀
• Gbigba infurarẹẹdi <197K>
ASAY
• Ilana
Ojutu ayẹwo: 140 miligiramu ti Tranexamic Acid ni 20 milimita ti glacial acetic acid
Titrimetric eto
(Wo Titrimetry <541>.)
Ipo: Taara titration
Titrant: 0.1 N perchloric acid VS
Wiwa ipari: Potentiometric
Onínọmbà
Apeere: Apeere ojutu
Titrate pẹlu 0.1 N perchloric acid VS, ṣiṣe ipinnu aaye ipari ni agbara.Gbe jade kan òfo titration.
Olukuluku milimita ti 0.1 N perchloric acid jẹ deede si 15.72 mg ti C8H15NO2.
Awọn ilana gbigba: 99.0% -101.0% lori ipilẹ ti o gbẹ
ALÁÌṢẸ́
Awọn Egbin Aiṣedeede
• Ajẹkù lori Iginisonu <281>: NMT 0.1%;Ayẹwo 1-g ti lo
• Awọn irin Heavy, Ọna II <231>: NMT 10 ppm
• Chloride ati Sulfate, Chloride <221>: Apin 0.51-g fihan ko si kiloraidi diẹ sii ju ni ibamu si 0.1 mL ti 0.020 N hydrochloric acid (0.014%).
Organic impurities
• Ilana
Ipele alagbeka: Tu 11.0 g ti iṣuu soda fosifeti monobasic anhydrous ninu omi 500 milimita, ki o ṣafikun 5 milimita ti triethylamine, atẹle nipa 1.4 g ti sodium lauryl sulfate.Ṣatunṣe pẹlu phosphoric acid ti fomi (10% w/w) si pH kan ti 2.5, ati dilute pẹlu omi si 600 milimita.Illa ojutu yii pẹlu 400 milimita ti methanol.
Ojutu ìbójúmu eto: 0.2 mg/mL ti USP Tranexamic Acid RS ati 0.002 mg/mL ti USP Tranexamic Acid Compound Jẹmọ C RS ninu omi
Ojutu boṣewa: 50 µg/ml ti USP Tranexamic Acid RS ninu omi
Ojutu ayẹwo: 10 mg/ml ti Tranexamic Acid ninu omi
Eto Chromatographic
(Wo Chromatography <621>, Ibamu Eto.)
Ipo: LC
Oluwadi: UV 220 nm
Ọwọn: 4.6-mm × 25-cm;5-µm iṣakojọpọ L1
Oṣuwọn sisan: 1 milimita / min
Iwọn abẹrẹ: 20µL
Akoko ṣiṣe: awọn akoko 3 akoko idaduro tranexamic acid
Ibamu eto
Apeere: Eto ibamu ojutu
Awọn ibeere ibamu
Ipinnu: NLT 2.0 laarin Tranexamic Acid ati 0.002 mg/mL ti tranexamic acid ti o ni ibatan agbo C
Onínọmbà
Awọn apẹẹrẹ: Ojutu boṣewa ati ojutu Ayẹwo
Ṣe iṣiro ipin ogorun aimọ kọọkan kọọkan ni apakan ti Tranexamic Acid ti o mu:
Esi = (rU/rS) × (CS/CU) × (0.1F)
rU = idahun ti o ga julọ fun aimọ kọọkan lati inu ojutu Ayẹwo
rS = idahun ti o ga julọ fun tranexamic acid lati inu ojutu Standard
CS = ifọkansi ti USP Tranexamic Acid RS ninu ojutu Standard (µg/ml)
CU = ifọkansi ti Tranexamic Acid ninu ojutu Ayẹwo (mg/mL)
F = ifosiwewe idahun ojulumo (wo Tabili Aimọ 1)
Awọn ilana gbigba
Awọn aimọ ẹnikọọkan: Wo Tabili Aimọ 1.
Lapapọ awọn aimọ: NMT 0.2%
[Akiyesi-Kọju eyikeyi tente ti o kere ju 0.025%.]
Tabili àìmọ́ 1
Orukọ Aago Idaduro Ojulumo Awọn Ilana Gbigba Idahun Ibaṣepọ, NMT (%)
Tranexamic acid ti o ni ibatan agbo Aa 2.1 1 0.1
Tranexamic acid ti o ni ibatan agbo Bb 1.5 1.2 0.2
Tranexamic acid ti o ni ibatan CC 1.1 0.005 0.1
Tranexamic Acid 1.0 1.0 —
Tranexamic acid ti o ni ibatan agbo Dd 1.3 0.006 0.1
trans, trans-4,4 ¢-(Iminodimethylene) di (cyclohexanecarboxylic) acid.
b cis-4- (Aminomethyl) cyclohexanecarboxylic acid.
c (RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
d 4-Aminomethyl benzoic acid.
Awọn idanwo pataki
• Isonu lori Gbigbe <731>: Gbẹ 1.00 g ni 105 labẹ igbale fun wakati 2.O padanu NMT 0.5% ti iwuwo rẹ.
Awọn ibeere afikun
• Iṣakojọpọ ati Ibi ipamọ: Fipamọ sinu awọn apoti wiwu, ati tọju ni iwọn otutu ti ko kọja 30.
• Awọn Ilana Itọkasi USP <11>
USP Tranexamic Acid RS Tẹ lati Wo Eto
USP Tranexamic Acid Jẹmọ Agbo C RS
(RS) -4- (Aminomethyl) cyclohex-1-enecarbocylic acid.
C8H13NO2 155
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Awọn aami ewu Xi - Irritant
Awọn koodu Ewu 36/37/38 - Irritating si oju, eto atẹgun ati awọ ara.
Apejuwe Abo
S26 - Ni ọran ti olubasọrọ pẹlu awọn oju, fi omi ṣan lẹsẹkẹsẹ pẹlu ọpọlọpọ omi ki o wa imọran iṣoogun.
S36 - Wọ aṣọ aabo to dara.
S37/39 - Wọ awọn ibọwọ ti o dara ati aabo oju / oju
WGK Germany 2
RTECS GU8400000
HS koodu 2922491100
Ewu Class IRRITANT
Majele LD50 ninu eku, eku (mg/kg): 1500, 1200 iv (Melander)
Tranexamic Acid (CAS: 1197-18-8) jẹ itọsẹ sintetiki ti amino acid lysine.Tranexamic acid (ti o wọpọ fun tita ni fọọmu tabulẹti bi Lysteda ati ni fọọmu IV bi Cyklokapron ni AMẸRIKA ati bi Transamin,Transcam ni Asia, ati Espercil). ni South America) ni a fun ni aṣẹ nigbagbogbo fun ẹjẹ ti o pọ ju.Tranexamic acid jẹ antifibrinolytic ti o ni idije ti o ṣe idiwọ imuṣiṣẹ ti plasminogen si plasmin, moleku ti o ni iduro fun ibajẹ fibrin.Fibrin jẹ ilana ipilẹ fun dida didi ẹjẹ kan ninu hemostasis.Tranexamic acid ni ni aijọju awọn akoko 8 iṣẹ antifibrinolytic ti afọwọṣe agbalagba, ε-aminocaproic acid.O jẹ itọsi akọkọ ni ọdun 1957 ati pe o gba ifọwọsi akọkọ AMẸRIKA ni 1986. Tranexamic Acid Appliciton Ti a lo bi awọn ohun ikunra funfun O ti wa ni lilo pupọ ni ile-iwosan ni awọn aaye iṣẹ abẹ, oogun inu, urology, obstetrics ati gynecology, ati bẹbẹ lọ lati tọju awọn arun ẹjẹ lọpọlọpọ ati ẹjẹ ajeji nigba iṣẹ abẹ, ati bẹbẹ lọ A gba bi oogun iṣọn-ẹjẹ, eyiti a lo fun hemostasis lẹhin iṣẹ abẹ nla ati lẹhin ibimọ.Nitoribẹẹ, hemostasis ṣee ṣe idi ti o kere julọ ti ọpọlọpọ awọn pasteti ehin ti wa ni afikun si ireti lati ni ipa kan.
Acid Tranexamic (CAS: 1197-18-8)
Iṣẹ abẹ ọkan
Wọpọ ti a lo ninu iṣẹ abẹ ọkan, mejeeji pẹlu ati laisi fori ọkan ọkan ẹdọforo.O rọpo aprotinin.
Ẹjẹ nkan oṣu
Ti a lo bi itọju akọkọ lainihormonal ti ẹjẹ uterine dysfunctional, ati ẹjẹ ti o wuwo ni nkan ṣe pẹlu fibroids uterine.Iwadi kan laipe fihan awọn alaisan ti a tọju pẹlu tranexamic acid ni o ṣeeṣe lati ni idagbasoke thrombosis ati negirosisi ninu awọn fibroids wọn, ati pe o le ja si irora ati iba.
Ipa funfun
Awọn iwadii ile-iwosan fun awọn ọdun ti fihan pe tranexamic acid le ṣe dilute aaye ni imunadoko ati ni iyara, eyiti o ṣe iranlọwọ lati ṣafihan awọ funfun ati didan pipe.Ipa imukuro aaye ti tranexamic acid jẹ nipa awọn akoko 50 lori Vitamin C, ati awọn akoko 10 ju AHA lọ.Iwọn ifọkansi ti lilo jẹ 2% -3%, ati ninu awọn ohun ikunra iye naa wa ni ayika 0.5%
1. Iduroṣinṣin to dara
Ti a ṣe afiwe pẹlu awọn eroja funfun ibilẹ, tranexamic acid ni iduroṣinṣin giga, acid ati resistance alkali, ati pe ko ni irọrun ni ipa nipasẹ agbegbe iwọn otutu;Ko si aabo ti ngbe, ko si ibajẹ eto gbigbe, ko si iwuri.
2. Eto awọ ara jẹ rọrun lati fa
O dara julọ fun awọn aaye itanna, funfun ati iwọntunwọnsi ohun orin awọ gbogbogbo.Ni afikun si imole awọn aaye, tranexamic acid tun le mu akoyawo ti awọ-ara gbogbogbo dara si ati didin ti ibi-ara agbegbe.
3. O le ipare dudu to muna, ofeefee freckles, irorẹ iṣmiṣ, ati be be lo
Awọn aaye dudu jẹ nitori ibajẹ UV ati ti ogbo awọ ara ati awọn nkan miiran.Clotting acid le ṣe idiwọ iṣẹ ṣiṣe ti tyrosinase ati melanocytes, dinku iṣelọpọ ti melanin lati Layer basal ti epidermis, ati tun ni ipa ti yiyọ awọn aaye pupa kuro.
4. Aabo giga
Idojukọ ti o ga julọ ni awọn ohun ikunra jẹ 2% ~ 3%.
5. Ipa funfun
Tranexamic Acid dara si gbogbo iru awọ ara fun yiyọ pigmenti, awọ funfun ati idinku awọn aaye, gẹgẹbi: Pigmentation lẹhin ifihan oorun;Awọn aaye dudu;Awọ ti o ni imọran;Irorẹ ati igbona;Itọju lẹhin iṣẹ abẹ lẹhin lesa, itọju ina pulsed.
