trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Purity>98.0% (HPLC) Afatinib Dimaleate Intermediate Aworan Ifihan

trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7 Mimọ>98.0% (HPLC) Afatinib Dimaleate Intermediate

Apejuwe kukuru:

trans-4-Dimethylaminocrotonic Acid Hydrochloride

CAS: 848133-35-7

Mimọ:> 98.0% (HPLC)

Irisi: Funfun si Fere White Powder

Agbedemeji ti Afatinib Dimaleate (CAS: 850140-73-7)

Olubasọrọ: Dokita Alvin Huang

Mobile/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

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ọja Tags

Apejuwe:

Ruifu Kemikali Ipese Intermediates of Afatinib
Afatinib CAS 439081-18-2
Afatinib Dimaleate CAS 850140-73-7
(S)-(+)-3-Hydroxytetrahydrofuran CAS 86087-23-2
(Dimethylamino) acetaldehyde Diethyl Acetal CAS 3616-56-6
trans-4-Dimethylaminocrotonic Acid Hydrochloride CAS 848133-35-7
Diethylphosphonoacetic Acid CAS 3095-95-2
7-Fluoro-6-Nitroquinazolin-4 (1H) -ọkan CAS 162012-69-3
7-Chloro-6-Nitro-4-Hydroxyquinazoline CAS 53449-14-2
N-(3-Chloro-4-Fluorophenyl)-7-Fluoro-6-Nitroquinazolin-4-Amine CAS 162012-67-1
(S) -N4- (3-Chloro-4-Fluorophenyl) -7- ((Tetrahydrofuran-3-yl) oxy) quinazoline-4,6-DiamineCAS 314771-76-1
(S)-N- (3-Chloro-4-Fluorophenyl)-6-Nitro-7-((Tetrahydrofuran-3-yl) oxy) quinazolin-4-AmineCAS 314771-88-5

Kemikali Properties:

Orukọ Kemikali	trans-4-Dimethylaminocrotonic Acid Hydrochloride
Awọn itumọ ọrọ sisọ	trans 4-Dimethylaminocrotonic Acid HCl;(E) -4- (Dimethylamino) -2-Butenoic Acid Hydrochloride;(E) -4-Dimethylaminocrotonic Acid Hydrochloride;(2E) -4- (Dimethylamino) ṣugbọn-2-Enoic Acid Hydrochloride;Afatinib int-2
Nọmba CAS	848133-35-7
Iṣura Ipo	Ninu Iṣura, Iwọn Iṣowo
Ilana molikula	C6H12ClNO2
Òṣuwọn Molikula	165.62
Ifamọ	Hygroscopic.Ọrinrin Sensitive
Ojuami Iyo	160.0 si 164.0 ℃
Solubility	DMSO (Diẹ), kẹmika (Diẹ), Omi (Diẹ)
COA & MSDS	Wa
Ipilẹṣẹ	Shanghai, China
Brand	Ruifu Kemikali

Awọn pato:

Nkan	Awọn pato
Ifarahan	Funfun to Fere White Powder
Mimọ / Analysis Ọna	> 98.0% (HPLC)
Mimọ / Analysis Ọna	> 98.0% (NMR)
Ọrinrin (KF)	<0.50%
Aloku lori Iginisonu	<0.20%
Aimọ Kanṣoṣo	<0.50%
Awọn irin Heavy (gẹgẹbi Pb)	<20ppm
Infurarẹẹdi julọ.Oniranran	Ni ibamu si Eto
1 H NMR julọ.Oniranran	Proton NMR julọ.Oniranran
Igbeyewo Standard	Standard Enterprise
Lilo	Intermediate of Afatinib, Afatinib Dimaleate

Package & Ibi ipamọ:

Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.

Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina ati ọrinrin.

Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.

Mimọ Chromatographic:

Irinse: Agilent 1200 HPLC HPLC chromatograph, DAD aṣawari.
Ọwọn: Agilent XDB-C18,250*4.6mm, 5μm
Ipele alagbeka: B: 1.95g soda octane sulfonate + 8ml phosphoric acid + 5ml triethylamine + 500ml omi
C: acetonitrile
Igbaradi ti apakan alagbeka ti o dapọ: mu 400ml B ojutu ati 100ml acetonitrile, dapọ daradara ati ni deede, ati fifa omi ni ipele kan.
Oṣuwọn sisan: 0.5ml/min54bar
Iwọn otutu: 25 ℃
Ipari: 210nm
Ojutu ayẹwo: apakan alagbeka ni a lo bi epo, apẹẹrẹ to lagbara: 0.0040g / 2ml, iwọn apẹẹrẹ 2.0μl.

Awọn anfani:

FAQ:

Ohun elo:

trans-4-Dimethylaminocrotonic Acid Hydrochloride (CAS: 848133-35-7) jẹ reagent ti a lo ninu igbaradi ti tyrosine kinase ti n ṣe idiwọ awọn aṣoju antitumor.trans-4-Dimethylaminocrotonic Acid Hydrochloride le ṣee lo bi agbedemeji Afatinib (CAS: 439081-18-2), Afatinib Dimaleate (CAS: 850140-73-7), Neratinib (CAS: 698387-09-6).Afatinib jẹ oogun ti a fọwọsi fun itọju ti kii-kekere sẹẹli ẹdọfóró carcinoma (NSCLC), ti a ṣe nipasẹ Boehringer Ingelheim.O ṣe bi oludena angiokinase.Bii Lapatinib ati Neratinib, Afatinib jẹ inhibitor tyrosine kinase (TKI) ti o tun ṣe idiwọ aibikita ti o ṣe idiwọ awọn olugba idagba idagbasoke ti eniyan 2 (Her2) ati awọn olugba idagba idagba epidermal (EGFR) kinases.Afatinib ko ṣiṣẹ nikan lodi si EGFRawọn iyipada ti a fojusi nipasẹ iran akọkọ TKIs likeerlotinib tabi gefitinib, ṣugbọn tun lodi si awọn ti ko ni ifarabalẹ si awọn itọju ailera boṣewa wọnyi.Nitori iṣẹ ṣiṣe afikun rẹ lodi si Her2, o ti wa ni iwadii fun akàn igbaya bi daradara bi EGFR miiran ati awọn aarun itọka Her2.Neratinib ti o ni idagbasoke nipasẹ ile-iṣẹ US Wyeth jẹ oludena ifosiwewe idagba epidermal ti ko ni iyipada (EGFR).O jẹ aaye ibi-afẹde pupọ ti awọn inhibitors tyrosine kinase moleku kekere si HER 2 ati HER1 lẹhin Lapatinib, ati pe o jẹ oludena olugba ErbB tyrosine kinase ti ko ni iyipada.Neratinib le ṣe idiwọ HER-1 ati HER-2 ti idile EGFR (IC50 jẹ 92 nmol/L ati 59 nmol/L, lẹsẹsẹ).Iwadi ile-iwosan fihan pe Neratinib ṣe ipa itọju ailera to ṣe pataki lori akàn ẹdọfóró sẹẹli ti kii-kekere, akàn ọgbẹ, ati akàn igbaya.Idanwo ile-iwosan alakosoⅡ fihan pe Neratinib ṣe afihan ipa ti o dara ati ifarada si awọn alaisan ti o ni idaniloju HER-2 pẹlu akàn igbaya ti o ti ni ilọsiwaju ti o ti gba tabi kii ṣe itọju Trastuzumab.Ipele Ⅲ idanwo ile-iwosan alakan igbaya ti pari ni Oṣu Kẹsan 2014.