Vitamin E-TPGS (Tocofersolan) CAS 9002-96-4 D-α-Tocopherol ≥25.0%
Shanghai Ruifu Chemical Co., Ltd jẹ olupilẹṣẹ asiwaju ti Vitamin E-TPGS (Tocofersolan) (CAS: 9002-96-4) pẹlu didara to gaju.Kemikali Ruifu le pese ifijiṣẹ agbaye, idiyele ifigagbaga, iṣẹ ti o dara julọ, kekere ati awọn iwọn olopobobo ti o wa.Ra Vitamin E-TPGS,Please contact: alvin@ruifuchem.com
| Orukọ Kemikali | Vitamin E Polyethylene Glycol Succinate |
| Awọn itumọ ọrọ sisọ | Vitamin E-TPGS;TPGS;Tocofersolan;α-Tocopherol Polyethylene Glycol Succinate;D-a-Tocopherol Polyethylene Glycol 1000 Succinate;alpha-Tocopherol Polyethylene Glycol Succinate |
| Iṣura Ipo | Ninu Iṣura, Iwọn Iṣowo |
| Nọmba CAS | 9002-96-4 |
| Fọọmu Molecular | C33H54O5.(C2H4O) n |
| Ojuami Iyo | 34.0 ~ 38.0 ℃ |
| iwuwo | 1.01g/cm3 |
| Ni imọlara | Afẹfẹ Ifamọ, Imọlẹ Imọlẹ, Imọra Ọrinrin |
| WGK Germany | 2 |
| Ibi ipamọ otutu. | Itura & Ibi Gbẹ (2 ~ 8℃) |
| COA & MSDS | Wa |
| Apeere | Wa |
| Ìdílé Kemikali | Vitamin E itọsẹ |
| Brand | Ruifu Kemikali |
| Awọn nkan | Ayewo Standards | Esi |
| Ifarahan | Pa-White to Bia Yellow Waxy Ri to | Ibamu |
| Idanimọ (GC) | Akoko idaduro ti tente oke pataki ti ojutu ayẹwo ni ibamu si ti ojutu Standard | Ibamu |
| Ojuami Iyo | 34.0 ~ 38.0 ℃ | 36.0 ~ 36,6 ℃ |
| Ayẹwo D-alpha Tocopherol | ≥25.0% (C29H50O2) | 26.4% |
| Tocopherol ọfẹ | ≤1.5% | Ibamu |
| Yiyi pato | ≥+24.0° | + 24,5° |
| Solubility ninu Omi | Ayẹwo 20g le ti wa ni tituka ni 80ml omi farabale | Ko o Laarin 3 wakati |
| Iye Acid | ≤0.27ml (0.10 N Sodium Hydroxide) | 0.22ml |
| Awọn Irin Eru (Pb) | ≤10ppm | <10ppm |
| Arsenic (Bi) | ≤1ppm | <1ppm |
| Asiwaju | ≤3ppm | <3ppm |
| Makiuri (Hg) | ≤0.1pm | <0.010ppm |
| Awọn ohun elo ti o ku | ||
| Ethyl acetate | ≤50ppm | Ko ṣe awari |
| Ethanol | ≤50ppm | 23ppm |
| Apapọ Awo kika | ≤1000CFU/g | <10CFU/g |
| Iwukara ati Molds | ≤100CFU/g | <10CFU/g |
| Salmonella | Odi | Odi |
| Escherichia Coli | Odi | Odi |
| Psendomonas Aeruginosa | Odi | Odi |
| Staphylococcus Aureus | Odi | Odi |
| Infurarẹẹdi julọ.Oniranran | Ni ibamu si Eto | Ibamu |
| Ipari | Ọja naa ti ni idanwo & ni ibamu pẹlu awọn pato ti a fun | |
Apo:Igo, apo apamọwọ Aluminiomu, 25kg / Paali Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Tọju ni wiwọ titi eiyan.Fipamọ sinu itura, gbigbẹ (2 ~ 8℃) ati ile-itaja ti o ni afẹfẹ daradara kuro ninu awọn nkan ti ko ni ibamu.Dabobo lati ina ati ọrinrin.
Gbigbe:Firanṣẹ si agbaye nipasẹ afẹfẹ, nipasẹ FedEx / DHL Express.Pese ifijiṣẹ yarayara ati igbẹkẹle.
ITUMO
Vitamin E Polyethylene Glycol Succinate jẹ adalu ti a ṣẹda nipasẹ esterification ti d-alpha tocopheryl acid succinate ati polyethylene glycol.Adalu ester ni nipataki ti mono-esterified polyethylene glycol ati kekere iye ti di-esterified polyethylene glycol.O ni NLT 25.0% ti d-alpha tocopherol (C29H50O2).
Ìdámọ̀
• A. Gas Chromatographic Idanimọ Idanwo
Onínọmbà: Tẹsiwaju bi a ti ṣe itọsọna ninu idanwo fun Akoonu ti Alpha Tocopherol.
Awọn ibeere gbigba: Akoko idaduro ti oke pataki ti ojutu Ayẹwo ni ibamu si ti ojutu Standard.
AWURE
• Akoonu ti Alpha Tocopherol
Solusan: 0.25 milimita ti phenolphthalein TS ni 1 L ti oti
Ojutu boṣewa inu: 12 mg/mL ti ethyl arachidate ni isooctane
Ojutu boṣewa: Gbigbe 32.5 miligiramu ti USP Alpha Tocopherol RS si ọpọn ifaseyin ti o yẹ.Fi 2 milimita ti pyridine kun ati 0.5 milimita ti N,O-bis(trimethylsilyl)trifluoroacetamide pẹlu 1% trimethylchlorosilane, ati ki o gbona igo ni 100 fun iṣẹju 10.Tutu igo naa, ṣafikun 5.0 milimita ti ojutu boṣewa Inu ti o tẹle pẹlu 20 milimita isooctane, ki o gbọn.
Ojutu Ayẹwo: Gbigbe opoiye deede si 0.100-0.160 g Vitamin E Polyethylene Glycol Succinate didà ni 60 si tube ti aṣa (nipa 20 cm gigun ati 2.5 cm ni iwọn ila opin) ti o ni ipese pẹlu fila skru.Fi 40-50 miligiramu ti ascorbic acid ati awọn eerun didan diẹ, ti o tẹle 20 milimita ti Solvent.[Akiyesi — Tun ojutu naa rọra laisi itujade ti akoonu.] Gbe tube ni a alapapo Àkọsílẹ ṣeto ni 100-150.Nigbati ayẹwo ba ti tuka ni kikun, ṣafikun 0.25 g ti potasiomu hydroxide, ki o tẹsiwaju lati reflux fun ọgbọn išẹju 30.Yọ tube lati ooru, ati nigba ti awọn akoonu ti si tun gbona, fi 1-2 milimita ti hydrochloric acid dropwise titi ti Pink coloration farasin.[Iṣọra-Idaran Exothermic.Gba acid laaye lati tan si isalẹ inu tube lati yago fun fifọ.] Tutu tube naa, lẹhinna wẹ awọn ẹgbẹ ti tube pẹlu 20 milimita ti omi.Ṣafikun milimita 5.0 ti ojutu boṣewa Inu, fila, ati gbọn lati rii daju pe o dapọ mọra.Gba tube laaye lati duro titi ti awọn ipele meji pato yoo fi ṣẹda.Gbigbe 2.5-3.5 milimita ti Layer oke sinu iyẹfun ifaseyin ti o dara, ki o si fi 2.0 milimita ti pyridine tẹle pẹlu 2.5 milimita ti N, O-bis (trimethylsilyl) trifluoroacetamide pẹlu 1% trimethylchlorosilane.Mu gilasi naa ni iwọn 100 fun iṣẹju 10.Dara, lẹhinna fi 12 milimita isooctane kun.
Eto Chromatographic
(Wo Chromatography 621, Ibamu Eto.)
Ipo: GC
Oluwadi: ina ionization
Ọwọn: 0.25-mm × 15-m fused-silica capillary;ti a bo pẹlu fiimu 0.25-µm ti alakoso G27
Iwọn otutu
Abẹrẹ: 280
Oluwadi: 345
Àwòrán: Wo Tabili 1.
Tabili 1
Iwọn otutu akọkọ (°) Iwọn otutu (°/min) Iwọn otutu ikẹhin (°) Aago Daduro ni Ipari otutu (min)
260 20 340 1
Gaasi ti ngbe: Helium
Oṣuwọn sisan: 1.5 milimita / min
Iwọn abẹrẹ: 1µL
Iru abẹrẹ: Pipin ratio, 200:1
Ibamu eto
Apeere: Standard ojutu
Awọn ibeere ibamu
Okunfa tailing: NMT 2.0 fun alpha tocopherol tente oke
Iyatọ boṣewa ibatan: NMT 2.0% fun ipin ti agbegbe oke tocopherol alpha si agbegbe tente oke boṣewa inu inu
Onínọmbà
Awọn apẹẹrẹ: Ojutu Standard ati Ayẹwo Solusan
Ṣe iṣiro ipin d-alpha tocopherol (C29H50O2) ni apakan Vitamin E Polyethylene Glycol Succinate ti o mu:
Esi = (RU/RS) × (WS/WU) × 100
RU= ipin boṣewa inu (agbegbe tente oke ti alpha tocopherol/agbegbe oke ti boṣewa inu) lati inu ojutu Ayẹwo
RS= ipin boṣewa inu (agbegbe tente oke ti alpha tocopherol/agbegbe tente oke ti boṣewa inu) lati ojutu Standard
WS = iwuwo USP Alpha Tocopherol RS ti a lo lati ṣeto ojutu Standard (mg)
WU= iwuwo Vitamin E Polyethylene Glycol Succinate ti a mu lati mura ojutu Ayẹwo (mg)
Awọn ibeere gbigba: NLT 25.0%
Awọn idanwo pataki
• Yiyi opitika, Yiyi pato 781S
[Akiyesi- Idanwo yii ṣe idanimọ d-alpha tocopherol lẹhin saponification.]
Ojutu Ayẹwo: Gbigbe 0.9 g ti Vitamin E Polyethylene Glycol Succinate, didà ni 60, si tube idanwo ti o yẹ ti o ni ibamu pẹlu fila, ati tu ni 10.0 milimita oti.Gbe tube naa sinu idina alapapo ti a ṣeto si 100-105.[Akiyesi-Reflux ojutu rọra laisi itujade ti akoonu.] Nigbati ayẹwo ba ti ni tituka ni kikun, fi awọn pellets 2-3 ti iṣuu soda hydroxide kun, ki o tẹsiwaju lati reflux fun afikun 30 min.Yọ tube kuro ninu ooru, ati nigba ti awọn akoonu ba wa ni gbona, yomi lilo phenolphthalein bi awọn Atọka nipa fifi laiyara 10 milimita adalu omi ati hydrochloric acid (1:1) titi ti Pink awọ disappears.[Iṣọra-Ihuwasi Exothermic.Jẹ ki ojutu acid lati tan si isalẹ inu tube lati yago fun fifọ.] Tutu tube, fila, ki o gbọn titi ti akoonu yoo fi dapọ daradara.Fi 25.0 milimita ti heptane, fila, ati gbigbọn fun iṣẹju 1 lati rii daju pe o dapọ daradara.Gba tube laaye lati duro titi ti awọn ipele meji pato yoo fi ṣẹda.Gbe ipele oke lọ si mimọ, tube asa gbigbẹ, lẹhinna fi 10.0 milimita omi kun si ojutu ti o gba pada.Fila, gbọn, ati gba awọn ipele lati yapa.Gbe ipele oke lọ si mimọ, tube gbigbẹ.Fi 10.0 milimita ti ojutu potasiomu ferricyanide kun, ti a pese sile nipasẹ itu 2 g ti potasiomu ferricyanide ni 10.0 milimita ti 0.2 M sodium hydroxide, ki o rọpo fila naa.Gbọn ni agbara fun awọn iṣẹju 45, ati gba awọn ipele lati ya sọtọ fun ọgbọn išẹju 30.Ti oke heptane Layer jẹ kedere, tẹsiwaju pẹlu wiwọn fun yiyi pato;ti ko ba han, gbẹ lori sulfate sodium anhydrous ṣaaju ki o to tẹsiwaju pẹlu idanwo naa.[Akiyesi-Lo awọn abajade idanwo fun Akoonu ti Alpha Tocopherol lati ṣe iṣiro iyipo kan pato.]
awọn ilana gbigba: NLT +24.0
• Solubility ninu Omi
Ayẹwo: 20 g ti yo o Vitamin E Polyethylene Glycol Succinate
Onínọmbà: Gbe Ayẹwo naa sinu apoti gilasi kan lori aruwo oofa.Lẹsẹkẹsẹ fi 80 milimita ti omi farabale lakoko ti o nru.Gba laaye lati tutu si iwọn otutu yara pẹlu igbiyanju igbagbogbo.
Awọn ibeere gbigba: Ojutu naa di mimọ laarin awọn wakati 3.
• Iye Acid
Ayẹwo: 1 g ti Vitamin E Polyethylene Glycol Succinate
Onínọmbà: Tu Ayẹwo ni 25 milimita ti adalu oti ati ether (1: 1) ti a ti yọkuro si phenolphthalein pẹlu 0.1 N sodium hydroxide.Fi 0.5 milimita ti phenolphthalein TS kun, ki o si titrate pẹlu 0.10 N sodium hydroxide titi ti ojutu yoo wa ni airẹwẹsi Pink lẹhin gbigbọn fun ọgbọn išẹju 30.
Awọn ilana gbigba: NMT 0.027 mEq/g, deede si NMT 0.27 mL ti 0.10 N sodium hydroxide
Awọn ibeere afikun
• Iṣakojọpọ ati Ibi ipamọ: Fipamọ sinu awọn apoti ti o nipọn, ati tọju aabo lati ina.
• Ifi aami: Iforukọsilẹ tọkasi akoonu d-alpha tocopherol, ti a fihan ni mg/g.
• Awọn Ilana Itọkasi USP 11
USP Alpha Tocopherol RS
Bawo ni lati Ra?Jọwọ kan siDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com
15 Ọdun Iriri?A ni diẹ sii ju ọdun 15 ti iriri ni iṣelọpọ ati okeere ti ọpọlọpọ awọn agbedemeji elegbogi didara tabi awọn kemikali to dara.
Awọn ọja akọkọ?Ta si ọja ile, North America, Europe, India, Korea, Japanese, Australia, ati be be lo.
Awọn anfani?Didara to gaju, idiyele ifarada, awọn iṣẹ alamọdaju ati atilẹyin imọ-ẹrọ, ifijiṣẹ yarayara.
DidaraIdaniloju?Eto iṣakoso didara to muna.Awọn ohun elo ọjọgbọn fun itupalẹ pẹlu NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, OR, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, bbl
Awọn apẹẹrẹ?Pupọ awọn ọja pese awọn apẹẹrẹ ọfẹ fun igbelewọn didara, idiyele gbigbe yẹ ki o san nipasẹ awọn alabara.
Ayẹwo ile-iṣẹ?Ayẹwo ile-iṣẹ kaabo.Jọwọ ṣe ipinnu lati pade ni ilosiwaju.
MOQ?Ko si MOQ.Ibere kekere jẹ itẹwọgba.
Akoko Ifijiṣẹ? Ti o ba wa laarin ọja iṣura, iṣeduro ifijiṣẹ ọjọ mẹta.
Gbigbe?Nipa Express (FedEx, DHL), nipasẹ Air, nipasẹ Okun.
Awọn iwe aṣẹ?Lẹhin iṣẹ tita: COA, MOA, ROS, MSDS, ati bẹbẹ lọ ni a le pese.
Aṣa Synthesis?Le pese awọn iṣẹ iṣelọpọ aṣa lati baamu awọn iwulo iwadii rẹ dara julọ.
Awọn ofin sisan?Iwe risiti Proforma yoo firanṣẹ ni akọkọ lẹhin ijẹrisi aṣẹ, ti ifi alaye banki wa sinu.Isanwo nipasẹ T/T (Telex Gbigbe), PayPal, Western Union, ati bẹbẹ lọ.
Vitamin E Polyethylene Glycol Succinate (Vitamin E-TPGS; TPGS; Tocofersolan) (CAS: 9002-96-4) jẹ ọja sintetiki.O wa bi funfun-funfun si biba ofeefee waxy Solid ati pe o jẹ alaiṣe itọwo.Kemikali, o jẹ adalu ti o ni akọkọ ti polyethylene glycol 1000 monoesterified, polyethylene glycol disterified 1000, polyethylene glycol 1000 ọfẹ, ati tocopherol ọfẹ.
Vitamin E Polyethylene Glycol Succinate ti ni lilo pupọ ni iwadii elegbogi, bi solubilizer, olupolowo gbigba, emulsifier, plasticizer ati ti ngbe ti omi-inoluble tabi eto ifijiṣẹ oogun ti o sanra, gẹgẹbi pipinka to lagbara, ti ngbe fun ifijiṣẹ oogun oju, ti ngbe fun intranasal ifijiṣẹ oogun, ati bẹbẹ lọ Bi awọn afikun ounjẹ.
Vitamin E Polyethylene Glycol Succinate jẹ itọsẹ omi-tiotuka ti Vitamin E, o ti ṣẹda nipasẹ didaṣe ẹgbẹ carboxyl ti Vitamin E succinate pẹlu ẹgbẹ hydroxyl ti polyethylene glycol.Nitoripe o ni awọn mejeeji Vitamin E lipophilic ẹgbẹ ati polyethylene glycol hydrophilic gun pq, o ni o ni ti o dara surfactant-ini ati omi solubility, eyi ti o le significantly mu awọn gbigba ti insoluble oloro ni nipa ikun ati inu ngba, pọ bioavailability.
Ni awọn ọdun aipẹ, ọpọlọpọ awọn ijinlẹ ti rii pe TPGS kii ṣe nikan ni a le lo bi awọn oogun elegbogi, ṣugbọn tun ni ọpọlọpọ awọn abuda alailẹgbẹ, bi awọn imudara imudara ati awọn aṣoju ifasilẹ awọn oogun pupọ, TPGS tun le lo si awọn prodrugs, micelles, liposomes, TPGS-copolymer. awọn ti ngbe lati ṣe ilọsiwaju solubility, permeability ati iduroṣinṣin ti igbaradi, nitorinaa lati ṣaṣeyọri o lọra, itusilẹ iṣakoso ati ipa ibi-afẹde, ṣe igbelaruge gbigba awọn oogun.
1. Elegbogi - Vitamin E-TPGS ṣe alekun gbigba, bioavailability ati imunadoko ti awọn ohun elo elegbogi (APIs)
2. Awọn afikun ounjẹ ounjẹ - Vitamin E-TPGS ni a lo lati ṣe agbekalẹ awọn afikun, paapaa awọn ti a ṣẹda lati mu ilọsiwaju laabu ti Vitamin E ati awọn ounjẹ lipophilic miiran ati awọn nutraceuticals.
3. Ounjẹ ati Ohun mimu - Vitamin E-TPGS le jẹ oojọ lati fidi awọn ounjẹ ati ohun mimu, awọn ohun mimu ere idaraya, omi ati awọn oje
4. Abojuto ti ara ẹni - Vitamin E-TPGS ṣiṣẹ bi ọfẹ ethanol, hypoallergenic, emulsifier ti ko ni ibinu / olutayo ni itọju ti ara ẹni ati awọn ohun elo ikunra.
5. Awọn ọja Ounjẹ Eranko - Vitamin E-TPGS n pese Vitamin E ti o ni agbara pupọ ati bioavailable fun awọn ẹranko ti ko fa awọn fọọmu ibile ti Vitamin E daradara daradara.
Vitamin E polyethylene glycol succinate jẹ ẹya esterified Vitamin E (tocopherol) itọsẹ nipataki lo bi awọn kan solubilizer tabi emulsifying oluranlowo nitori ti awọn oniwe-surfactant-ini.Ni igbekalẹ, o jẹ amphipathic ati hydrophilic, ko dabi awọn tocopherols, ati nitori naa o jẹ itọsẹ ti omi-tiotuka ti o le ṣee lo ni awọn ilana oogun gẹgẹbi awọn capsules, awọn tabulẹti, extrusion gbigbona, awọn microemulsions, awọn ọja agbegbe, ati awọn obi obi.Ọkan ninu awọn ohun elo pataki julọ ni lilo rẹ bi ọkọ fun awọn agbekalẹ ifijiṣẹ oogun ti o da lori ọra.O tun le ṣee lo bi orisun ti Vitamin E. Vitamin E polyethylene glycol succinate ti ni ijuwe pẹlu ọna ṣiṣe ti iṣe rẹ ati iwadi bi onidalẹkun Pglycoprotein.
Vitamin E polyethylene glycol succinate ko ni ibamu pẹlu awọn acids ti o lagbara ati awọn alkalis ti o lagbara.
GRAS akojọ.To wa ninu aaye data Awọn eroja aiṣiṣẹ ti FDA (ojutu oju tabi awọn silẹ; awọn capsules ẹnu, ojutu, tabulẹti; ojutu agbegbe tabi awọn silẹ).Ti o wa ninu Atokọ Ilu Kanada ti Awọn ohun elo ti kii ṣe oogun ti o ṣe itẹwọgba.
