Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2 API Didara Giga
Ipese Vonoprazan Fumarate ati ibatan Intermediate
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Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Orukọ Kemikali | Vonoprazan Fumarate |
| Awọn itumọ ọrọ sisọ | TAK-438 |
| Nọmba CAS | 1260141-27-2;881681-01-2 |
| NỌMBA CAT | RF-API99 |
| Iṣura Ipo | Ninu Iṣura, Iwọn iṣelọpọ Ti o to Awọn ọgọọgọrun Kilogram |
| Fọọmu Molecular | C21H20FN3O6S |
| Òṣuwọn Molikula | 461.463 |
| Brand | Ruifu Kemikali |
| Nkan | Awọn pato |
| Ifarahan | Funfun tabi Fere-White Crystalline Powder |
| Idanimọ 1 H-NMR | Ni ibamu pẹlu Standard |
| Idanimọ IR | Awọn irisi gbigba IR ti concordant ayẹwo pẹlu boṣewa itọkasi |
| HPLC idanimọ | Akoko idaduro ti concordant ayẹwo pẹlu boṣewa itọkasi |
| Omi akoonu | ≤0.50% |
| Aloku lori Iginisonu | ≤0.20% |
| Awọn irin Heavy (gẹgẹbi Pb) | ≤20ppm |
| Awọn nkan ti o jọmọ | |
| Aimọ́ A | ≤0.20% |
| Aimọ́ B | ≤0.15% |
| Iwa aimọ C | ≤0.15% |
| Eyikeyi Iwa Aimọ | ≤0.10% |
| Lapapọ Awọn Aimọ | ≤1.0% |
| Awọn ohun elo ti o ku | |
| kẹmika kẹmika | ≤0.30% |
| Ethanol | ≤0.50% |
| Ethyl acetate | ≤0.50% |
| Aseyori / Analysis Ọna | 98.0% ~ 102.0% (Nipasẹ HPLC) |
| Igbeyewo Standard | Standard Enterprise |
| Lilo | API |
Package: Igo, apo apamọwọ Aluminiomu, ilu paali, 25kg / Drum, tabi gẹgẹbi ibeere alabara.
Ipò Ìpamọ́:Fipamọ sinu awọn apoti ti a fi edidi ni itura ati ibi gbigbẹ;Dabobo lati ina, ọrinrin.
Vonoprazan Fumurate (TAK-438) (CAS: 1260141-27-2; 881681-01-2), proton fifa inhibitor (PPI), jẹ agbara ati ẹnu ti nṣiṣe lọwọ potasiomu-ifigagbaga acid blocker (P-CAB), pẹlu antisecretory aṣayan iṣẹ-ṣiṣe.Vonoprazan Fumarate ṣe idiwọ iṣẹ H+,K+-ATPase ni awọn microsomes inu porcine pẹlu IC50 ti 19 nM ni pH 6.5.Vonoprazan Fumarate (Takecab), ti a ṣe awari ati idagbasoke nipasẹ Takeda ati Otsuka, ti fọwọsi nipasẹ PMDA ti Japan ni Oṣu Kejila ọdun 2014. Vonoprazan Fumarate jẹ eyiti a lo fun itọju ti ikolu helicobacter pylori, gastroesophageal reflux, ọgbẹ peptic, ọgbẹ duodenal, esophagitis, ikun inu. ọgbẹ ati awọn arun inu ikun miiran.Awọn ọja ni o ni kan to lagbara, pípẹ idinamọ ti inu yomijade acid.Ni iwọn lilo itọju, Vonoprazan Fumarate ko ni ipa diẹ lori awọn enzymu miiran ati ipa kekere lori awọn iṣẹ iṣe ti ara.O jẹ ailewu ati ifarada diẹ sii.
