1,3,5-Tri-O-benzoyl-D-Ribofuranose CAS 22224-41-5 Ubumsulwa ≥99.0% Clofarabine Intermediate High Purity
I-Commercial Supply Okuhlobene Okuhlobene:
I-Clofarabine CAS: 123318-82-1
2-Deoxy-2-fluoro-1,3,5-tri-O-benzoyl-α-D-arabinofuranose CAS: 97614-43-2
I-β-D-Ribofuranose 1-Acetate 2,3,5-Tribenzoate CAS: 6974-32-9
1,3,5-Tri-O-benzoyl-D-Ribofuranose CAS: 22224-41-5
I-2,6-Dichloropurine CAS: 5451-40-1
Igama Lekhemikhali | 1,3,5-Tri-O-benzoyl-D-Ribofuranose |
Inombolo ye-CAS | 22224-41-5 |
Inombolo yeCAT | I-RF-PI223 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C26H22O8 |
Isisindo samangqamuzana | 462.45 |
I-Melting Point | 125.0-129.0℃(lit.) |
Ukuncibilika | Ayincibiliki Emanzini |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Emhlophe noma Engamhlophe |
Ubumsulwa | ≥99.0% |
Ukulahlekelwa Ekumisweni | ≤1.00% |
Ukungcola Okukodwa Okukhulu | ≤0.50% |
Ukungcola Okuphelele | ≤1.00% |
Izinsimbi Ezisindayo | ≤20ppm |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Intermediate ye-Clofarabine (CAS: 123318-82-1) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-1,3,5-Tri-O-benzoyl-D-Ribofuranose (i-CAS: 22224-41-5) iyinto yokuqala ye-nucleoside synthesis.Ingasetshenziswa njengendawo ephakathi yeClofarabine (CAS: 123318-82-1).I-Clofarabine iyinoveli yemithi elwa nomdlavuza we-purine nucleoside eqala ukuthuthukiswa ngempumelelo yi-Top10 biopharmaceutical company ye-United States-Genzyme Corporation amagama okuhweba athi “Clofarabine”.Ngomhla zingama-28 kuZibandlela wezi-2004 i-FDA yasebenzisa i-fast-track ukuze igunyaze i-Clofarabine ukuze isetshenziswe ezinganeni ezine-refractory noma i-relapsed acute lymphocytic leukemia.I-Clofarabine ihlanganisa izinzuzo ze-Fludarabine ne-Cladribine ukuvimbela kokubili i-DNA polymerase ne-RIbonucleic acid reductase.Njengamanje ukuphela kwesidakamizwa esifanele ukwelashwa kwe-leukemia yezingane.Ucwaningo luye lwafakazela ukuthi ukusebenza kahle kwayo kokwelapha kuphezulu kakhulu, futhi izinga lokuphendula eliphelele leziguli ezingenayo impendulo kumakhemikhali amabili avamile angama-31%.Futhi ukubekezelelana ngesineke kuhle, akukho ukusabela okubi okungalindelekile;Inezici ezingase zibe ne-broad-spectrum antitumor.