I-2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4 Ukuhlanzeka >99.5% (HPLC) I-Tipiracil Hydrochloride Intermediate Factory
Ukuhlinzeka Ngomkhiqizi, Ikhwalithi Ephezulu kanye Nentengo Encintisanayo
I-Tipiracil Hydrochloride (CAS: 183204-72-0) Izikhulumi Ezihlobene
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I-2-Amino-1-Pyrroline Hydrochloride CAS 7544-75-4
| Igama Lekhemikhali | I-2-Amino-1-Pyrroline Hydrochloride |
| Omqondofana | I-3,4-Dihydro-2H-Pyrrol-5-Amine Hydrochloride;2-Aminopyrrolidine HCl |
| Inombolo ye-CAS | 7544-75-4 |
| Inombolo yeCAT | I-RF-PI1838 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | C4H8N2·HCl |
| Isisindo samangqamuzana | 120.58 |
| I-Melting Point | 171.0 ukuze 175.0 ℃ |
| Kuyazwela | I-Hygroscopic |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane | Imiphumela |
| Ukubukeka | Impushana Emhlophe | Impushana Emhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.5% (HPLC) | 99.8% |
| Ukungcola Okukodwa Okukhulu | <0.50% | 0.09% |
| Okuqukethwe kwamanzi (KF) | <0.50% | 0.45% |
| I-Proton NMR Spectrum | Ivumelana Nesakhiwo | Kuyavumelana |
| Izinga Lokuhlola | I-Enterprise Standard | |
| Ukusetshenziswa | Okumaphakathi kwe-Tipiracil Hydrochloride (CAS: 183204-72-0) | |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
I-2-Amino-1-Pyrroline Hydrochloride (i-CAS: 7544-75-4) i-heterocyclic organic compound, engasetshenziswa njengendawo ephakathi kwemithi.I-2-Amino-1-Pyrroline Hydrochloride iphakathi kwe-Tipiracil Hydrochloride (CAS: 183204-72-0) ekwelapheni i-Rectal Cancer.I-Tipiracil Hydrochloride iyi-inhibitor enamandla futhi eqhudelanayo ye-thymidine phosphorylase (TPase) enenani le-IC50 lama-35 nM ku-TPase ye-placental yomuntu.Ikhetha i-TPase ngaphezu kwamanye ama-enzyme e-pyrimidine-metabolizing (IC50s =>1 mM ye-UPase, OPRTase, TK, ne-DPDAse).I-TPI ivimbela i-phosphorolysis kanye nokuwohloka kwe-trifluorothymidine, i-cytotoxic nucleoside, emasampulini esifuba somuntu kanye ne-colon carcinoma tumor.Ukuphathwa ngomlomo kwe-TPI (12.5-50 mg/kg) kuthuthukisa umsebenzi wokulwa nesimila we-trifluorothymidine kumodeli yegundane ye-AZ-521 ye-xenograft yomdlavuza wesisu.Amafomula aqukethe i-TPI asetshenziselwe ukwelapha umdlavuza we-metastatic colorectal.
