I-2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5 Purity ≥98.0% I-Olaparib Intermediate Factory
Ukuhlanzeka Okuphezulu, Ukukhiqizwa Kwezohwebo
I-Olaparib kanye Nezixhumanisi Ezihlobene:
I-Olaparib CAS 763113-22-0
I-2-Fluoro-5-Formylbenzonitrile CAS 218301-22-5
2-Fluoro-5-((4-oxo-3,4-dihydrophthalazin-1-yl)methyl)benzoic acid CAS 763114-26-7
1-(Cyclopropylcarbonyl)piperazine Hydrochloride CAS 1021298-67-8
I-3-Oxo-1,3-Dihydroisobenzofuran-1-Ylphosphonic Acid CAS 61260-15-9
| Igama Lekhemikhali | 2-Fluoro-5-Formylbenzonitrile |
| Omqondofana | 3-Cyano-4-Fluorobenzaldehyde |
| Inombolo ye-CAS | 218301-22-5 |
| Inombolo yeCAT | I-RF-PI451 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C8H4FNO |
| Isisindo samangqamuzana | 149.12 |
| I-Melting Point | 80.0 kuye ku-84.0℃ (lit.) |
| Ukuncibilika | I-Soluble ku-Methanol |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana ephuzi ukuya kokumhlophe |
| Ubumsulwa | ≥98.0% |
| Umswakama (KF) | ≤0.50% |
| Ukungcola Okuphelele | ≤2.0% |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | Okumaphakathi kwe-Olaparib (CAS: 763113-22-0) PARP-Inhibitor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, I-Cardboard Drum, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
I-2-Fluoro-5-Formylbenzonitrile (i-CAS: 218301-22-5) isetshenziselwa ukulungiswa kwe-heterocyclic compounds njengama-inhibitors e-PARP ukuze asetshenziswe kwezokwelapha.I-2-Fluoro-5-Formylbenzonitrile isetshenziswa njenge-intermediate ye-Olaparib (CAS: 763113-22-0).I-Olaparib iyi-molecule encane inhibitor ye-PARP1/PARP2 (IC50: 5/1 nM) kodwa ayisebenzi kahle uma iqhathaniswa ne-PARP tankyrase-1 (IC50: 1.5 µM).I-Olaparib (AZD-2281, igama lokuhweba i-Lynparza) iwukwelapha okuhlosiwe okugunyazwe yi-FDA kumdlavuza, okwathuthukiswa yi-KuDOS Pharmaceuticals futhi kamuva yi-AstraZeneca.Kuyi-PARP inhibitor, inhibiting poly ADP ribose polymerase (PARP), i-enzyme ehilelekile ekulungiseni i-DNA.Isebenza ngokumelene nomdlavuza kubantu abanofuzo lwe-BRCA1 noma i-BRCA2 yokuguqulwa kwezakhi zofuzo, okuhlanganisa umdlavuza we-ovary, webele, nowe-prostate.NgoDisemba 2014, i-olaparib yagunyazwa ukuthi isetshenziswe njenge-ejenti eyodwa yi-EMA kanye ne-FDA.Ukugunyazwa kwe-FDA kumayelana ne-germline BRCA eguquliwe (gBRCAm) umdlavuza we-ovary othuthukisiwe othole imigqa emithathu noma ngaphezulu yangaphambili ye-chemotherapy.
