I-2-Methyltryptamine CAS 2731-06-8 Ubumsulwa >99.0% (HPLC) Panobinostat Imboni Emaphakathi Yekhwalithi Ephezulu
Ukuhlinzeka Ngomkhiqizi Ngekhwalithi Ephezulu, Ukukhiqiza Kwezentengiso
Igama Lekhemikhali: 2-Methyltryptamine CAS: 2731-06-8
Igama Lekhemikhali | 2-Methyltryptamine |
Omqondofana | 2-Methylindole-3-Ethylamine;2-(2-Methyl-1H-indol-3-yl) ethanamine;3-(2-Aminoethyl)-2-Methylindole |
Inombolo ye-CAS | 2731-06-8 |
Inombolo yeCAT | I-RF-PI1480 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C11H14N2 |
Isisindo samangqamuzana | 174.25 |
I-Melting Point | 106.0 ukuze 110.0 ℃ |
Iphuzu elibilayo | 177℃/1.5mmHg(lit.) |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | I-Brown Solid |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (Indawo ye-HPLC) |
1-HNMR | Ihambisana Nesakhiwo |
Ukulahlekelwa Ekumisweni | <1.00% |
Ukungcola Okukodwa | <0.50% |
Ukungcola Okuphelele | <1.00% |
Izinsimbi Ezisindayo (njenge-Pb) | <20ppm |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | Abalamuli Bezemithi;I-Panobinostat Ephakathi |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
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I-2-Methyltryptamine (i-CAS: 2731-06-8) iyinto eyinhloko yokuqala ekuhlanganiseni kwe-Panobinostat (LBH589) (CAS: 404950-80-7).I-Panobinostat iyi-inhibitor enamandla yawo wonke ama-histone deacetylases (i-HDACs), enamanani e-Ki asuka ku-0.6 ukuya ku-31 nM ku-HDAC1-11.Ngalesi senzo, kuholela ku-acetylation yohlu lwamaprotheni eselula, okuholela ekuboshweni komjikelezo wamaseli kanye ne-apoptosis kumaseli omdlavuza.I-Panobinostat iyisivimbeli sokuqala se-HDAC esigunyazwe yi-FDA ekwelapheni i-myeloma eminingi.I-Panobinostat idayiswa njenge-Farydak, isetshenziswa ngokuhambisana ne-Bortezomib (CAS: 179324-69-7) kanye ne-Dexamethasone (CAS: 50-02-2) ukuphatha i-myeloma eminingi ebuyele emuva ngemva kokwelashwa kwangaphambili nge-Bortezomib kanye ne-immunomodulator.
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