4-[(1-Pyrrolidinylsulfonyl)methyl]aniline CAS 334981-10-1 Purity>99.0% (HPLC) I-Almotriptan Aniline Precursor Factory
I-Ruifu Chemical Supply Almotriptan Malate Intermediates:
I-Almotriptan Malate CAS 181183-52-8
I-1-((4-Hydrazinylbenzyl)sulfonyl)pyrrolidine Hydrochloride CAS 334981-11-2
4-[(1-Pyrrolidinylsulfonyl)methyl]aniline CAS 334981-10-1
1-[(4-Nitrophenylmethyl)sulfonyl]pyrrolidine CAS 340041-91-0
I-4-Chlorobutyraldehyde Diethyl Acetal CAS 6139-83-9
Igama Lekhemikhali | 4- [(1-Pyrrolidinylsulfonyl)methyl]aniline |
Omqondofana | 1-[(4-Aminobenzyl)sulfonyl]pyrrolidine;I-Almotriptan Aniline Precursor |
Inombolo ye-CAS | 334981-10-1 |
Inombolo yeCAT | I-RF-PI1948 |
Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
I-Molecular Formula | I-C11H16N2O2S |
Isisindo samangqamuzana | 240.32 |
I-Melting Point | 170.0 ukuze 176.0 ℃ |
Ukuminyana | 1.31 |
Ukuncibilika | Incibilika Kancane ku-Toluene |
Ibhrendi | I-Ruifu Chemical |
Into | Imininingwane |
Ukubukeka | Impushana Eyikristalu Ephuzi ukuya Ephuzi |
Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) |
Ukulahlekelwa Ekumisweni | <0.50% |
Izinsalela ekushiseni | <0.50% |
Ukungcola Okukodwa Okukhulu | <0.50% |
Ukungcola Okuphelele | <1.00% |
Izinsimbi Ezisindayo | <20ppm |
I-Infrared Spectrum | Ivumelana Nesakhiwo |
I-NMR | Ivumelana Nesakhiwo |
Izinga Lokuhlola | I-Enterprise Standard |
Ukusetshenziswa | I-Almotriptan Aniline Precursor |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwemfuneko yekhasimende
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama
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I-4--[(1-Pyrrolidinylsulfonyl) methyl]aniline (CAS: 334981-10-1) iphakathi ekulungiseleleni i-Almotriptan Malate (CAS: 181183-52-8), i-Almotriptan Aniline Precursor.I-Almotriptan Malate iwuhlobo lomuthi we-triptan ongasetshenziswa ekwelapheni ubuhlungu bekhanda elibuhlungu.I-Almotriptan iyingxenye yezidakamizwa ezikhethiwe ze-serotonin receptor agonists.I-Almotriptan inobudlelwane obuphezulu nokucacile be-serotonin 5-HT receptors, okuholela phambili ekuvinjweni kwe-vascoconstriction yomkhumbi wegazi lobuchopho futhi kuthinte ukwabiwa kabusha kokugeleza kwegazi.Le miphumela imisa izimpawu zobuhlungu ukuthi zingathunyelwa ebuchosheni, futhi iqhubeke icindezela ukukhululwa kwezinto ezithile zemvelo ezibangela ubuhlungu, isicanucanu nezinye izimpawu ze-migraine.Kodwa-ke, i-Almotriptan ayikuvimbi ukuhlaselwa yi-migraine.I-Almotriptan, imakethwa ngo-2000, ine-oralbioavailability ephezulu kakhulu phakathi kwawo wonke ama-triptan.I-Almotriptan yenziwa i-metabolized yi-MAO-A ne-CYP3A4, ngakho-ke inephrofayili yemiphumela emihle kakhulu uma iqhathaniswa ne-Sumatriptan.