4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8 Purity >99.0% (HPLC) Aprepitant Intermediate Factory
Umkhiqizi ohamba phambili nomphakeli
Abaphakathi be-Aprepitant (CAS: 170729-80-3)
I-4-Benzyl-2-Hydroxymorpholin-3-one CAS 287930-73-8
(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2
Please contact: alvin@ruifuchem.com
| Igama Lekhemikhali | 4-Benzyl-2-Hydroxymorpholin-3-one |
| Omqondofana | I-4-Benzyl-2-Hydroxy-Morpholin-3-one;I-2-Hydroxy-4-(Phenylmethyl)-3-Morpholinone;Ukungcola kwe-Aprepitant 48;Ukungcola kwe-Fosaprepitant 23;I-Aprepitant Intermediate Ⅱ |
| Inombolo ye-CAS | 287930-73-8 |
| Inombolo yeCAT | I-RF2660 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C11H13NO3 |
| Isisindo samangqamuzana | 207.23 |
| I-Melting Point | 134.0 ukuze 138.0 ℃ |
| Iphuzu elibilayo | 441.7±45.0℃ |
| Ukuminyana | 1.292±0.06 g/cm3 |
| Ukuncibilika Emanzini | I-DMSO (Kancane), i-Methanol (Kancane, Eshisiwe) |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystal Powder emhlophe ukuya kokumhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | >99.0% (HPLC) |
| I-Melting Point | 134.0 ukuze 138.0 ℃ |
| Amanzi (nguKarl Fischer) | <0.50% |
| Izinsalela ekushiseni | <0.20% |
| Ukungcola Okuphelele | <1.00% |
| I-Proton NMR Spectrum | Ivumelana Nesakhiwo |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Intermediate of Aprepitant (CAS: 170729-80-3) Isidakamizwa se-Antiemetic |
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I-4-Benzyl-2-Hydroxymorpholin-3-one (CAS: 287930-73-8), iphakathi kwe-Aprepitant (CAS: 170729-80-3), esetshenziswa njengezidakamizwa ze-antiemetic.I-Aprepitant iyimphikisi ye-neurokinin-1 (NK-1) futhi ingeyemithi yokwelapha yokuhlanza ngesikhathi se-chemotherapy yomdlavuza.Yasungulwa ngempumelelo yiNkampani yakwaMerck (isiJalimane).NgoMashi 2003, i-US Food and Drug Administration yagunyaza ukuthi isetshenziselwe ukwelapha ukuhlanza ngamakhemikhali.Lo mkhiqizo unokuhlobana okuphezulu okukhethayo kubantu kuyilapho unokuhlobana okuphansi kwe-serotonin, i-dopamine ne-glucocorticoid receptor affinity.I-Aprepitant, uma ihlanganiswe ne-5-HT3 receptor inhibitors (njenge-ondansetron hydrochloride) kanye ne-corticosteroid dexamethasone, inganciphisa ngokuqhubekayo i-cisplatin-induced acute kanye (noma) i-emesis ebambezelekile.Ukusebenzisa lesi sidakamizwa kuphela kungaba nomphumela othile wokuvimbela.
![(R)-1-[3,5-Bis(trifluoromethyl)phenyl]ethanol CAS 127852-28-2 Purity>99.0% (GC) Aprepitant Intermediate](https://www.ruifuchemical.com/uploads/R-1-35-Bistrifluoromethylphenylethanol-CAS-127852-28-2-300x300.jpg)