I-4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS 327-78-6 Purity ≥99.0% I-Sorafenib Tosylate Intermediate Factory
I-Commercial Supply Sorafenib Tosylate kanye Nezixhumanisi Ezihlobene:
I-Sorafenib Tosylate CAS: 475207-59-1
I-Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
| Igama | 4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate |
| Omqondofana | I-Isocyanic Acid 4-Chloro-3-(Trifluoromethyl)phenyl Ester |
| Inombolo ye-CAS | 327-78-6 |
| Inombolo yeCAT | I-RF-PI167 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C8H3ClF3NO |
| Isisindo samangqamuzana | 221.56 |
| I-Melting Point | 37.0~42.0℃ (okhanyisiwe) |
| Iphuzu elibilayo | 86.0~90.0℃ 14 mmHg (lit.) |
| Ukuminyana | 1.4720 |
| Imibandela Yokuthumela | I-ambient |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Crystalline Emhlophe |
| Ukuhlanzeka / Indlela Yokuhlaziya | ≥99.0% (HPLC) |
| Ukuhlonza | (1) IR (2) HPLC |
| Umswakama (KF) | ≤0.50% |
| Izinsimbi Ezisindayo | ≤10ppm |
| Ukungcola A | ≤0.15% |
| Ukungcola B | ≤1.0% |
| Ukungcola C | ≤1.0% |
| Okunye Ukungcola Okukodwa | ≤0.50% |
| Ukungcola Okuphelele | ≤1.0% |
| I-Residual Solvent | I-Toluene ≤0.089% |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Intermediate ye-Sorafenib Tosylate (CAS: 475207-59-1) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
Umkhiqizi onokuhlanzeka Okuphezulu kanye Nekhwalithi Ezinzile
I-Commercial Supply Sorafenib Tosylate (CAS: 475207-59-1) Izimaphakathi Ezihlobene:
I-Sorafenib Tosylate CAS: 475207-59-1
I-Sorafenib CAS: 284461-73-0
4-Chloro-N-Methyl-2-Pyridinecarboxamide CAS: 220000-87-3
4-(4-Aminophenoxy)-N-Methylpicolinamide CAS: 284462-37-9
4-Chloro-3-(Trifluoromethyl)phenyl Isocyanate CAS: 327-78-6
I-Sorafenib Tosylate (CAS: 475207-59-1) iwuhlobo olusha lwesidakamizwa esilwa nesimila esihloselwe izinto eziningi, sathuthukiswa yi-German Bayer Pharmaceuticals, futhi yabonisa umsebenzi wokulwa nesimila owandayo ekuhlolweni kwezilwane ngaphambi komtholampilo.I-Sorafenib itholakala kumaphilisi angu-200-mg ukuze iphathwe ngomlomo futhi isetshenziselwa ukwelapha i-RCC ne-HCC.I-Sorafenib Tosylate (CAS: 475207-59-1) ingathinta kanyekanye amaseli e-tumor kanye nemithambo yegazi yesimila.Inomphumela we-antitumor ophindwe kabili: ingavimba izindlela zokudluliselwa kwesignali yeseli exhunywe yi-RAF/MEK/ERK ukuze ivimbele ngokuqondile ukukhula kwe-tumor cell, kuyilapho ivimbela i-VEGF ne-platelet derived growth factor (PDGF) ama-receptors ukuvimbela ukwakheka kwegazi elisha lesimila. imikhumbi, ngaleyo ndlela ivimbele ngokungaqondile ukukhula kwamaseli e-tumor.
