5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde CAS 881674-56-2 Vonoprazan Fumarate Intermediate Purity ≥99.0%
Ukunikezela nge-Vonoprazan Fumarate kanye Nezimaphakathi Ezihlobene
5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde CAS 881674-56-2
I-Pyridine-3-Sulfonyl Chloride CAS 16133-25-8
I-Vonoprazan Fumarate (TAK-438) CAS 1260141-27-2 881681-01-2
| Igama Lekhemikhali | 5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde |
| Omqondofana | I-Vonoprazan Fumarate (TAK-438) Emaphakathi 3 |
| Inombolo ye-CAS | 881674-56-2 |
| Inombolo yeCAT | I-RF-PI330 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C11H8FNO |
| Isisindo samangqamuzana | 189.19 |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | Impushana Ephuzi ukuya Ensundu |
| I-Melting Point | 122.0~131.0℃ |
| Ukuhlonza: RT(HPLC) | Vumelanisa Nezinga Lereferensi |
| Ukulahlekelwa Ekumisweni | ≤0.50% |
| I-Residue Ekushiseni | ≤0.50% |
| Izinto Ezihlobene | |
| Ubumsulwa | ≥99.0% |
| Noma Ikuphi Ukungcola Okukodwa | ≤0.50% |
| Ukungcola Okuphelele | ≤1.0% |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Intermediate of Vonoprazan Fumarate (TAK-438) (CAS 881681-01-2) |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, isigubhu seCardboard, 25kg/Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni, umswakama kanye nezinambuzane.
I-5-(2-Fluorophenyl)-1H-Pyrrole-3-Carbaldehyde (CAS 881674-56-2) isebenza njenge-reagent ekulungiseleleni okokwenziwa kokuphuma kwenoveli ye-pyrrole njenge-potassium-competitive acid blocker (P-CAB).I-5-(2-Fluorophenyl)pyrrole-3-Carboxaldehyde imaphakathi ne-Vonoprazan Fumarate (CAS 1260141-27-2).I-Vonoprazan fumarate (Takecab®), etholwe futhi yathuthukiswa ngabakwa-Takeda no-Otsuka, yagunyazwa yi-PMDA yaseJapane ngoDisemba 2014, futhi ikhonjiswe ukwelapha isilonda sesisu, isilonda se-duodenal kanye ne-reflux esophagitis.I-Vonoprazan fumarate inomshini wokusebenza wenoveli obizwa ngokuthi i-potassium-competitive acid blockers, evimbela ngokuncintisana ukuboshwa kwama-ion e-potassium ku-H+, K+-ATPase (eyaziwa nangokuthi iphampu ye-proton) esinyathelweni sokugcina sokuphuma kwe-asidi esiswini kumaseli e-gastric parietal.I-Vonoprazan ayivimbeli umsebenzi we-Na+, K+-ATPase ngisho nasekugxiliseni izikhathi ezingu-500 ngaphezu kwamanani e-IC50 uma kuqhathaniswa nomsebenzi wesisu we-H+, K+-ATPase.Ngaphezu kwalokho, umuthi awuthintwa yi-gastric secretory state, ngokungafani nama-PPI.
