I-5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4 I-Dapagliflozin Intermediate Factory
Ukunikezwa Komkhiqizi, Ukuhlanzeka Okuphezulu, Ukukhiqizwa Kwezohwebo
I-Dapagliflozin (CAS: 461432-26-8) Izimaphakathi Ezihlobene:
I-5-Bromo-2-Chlorobenzoic Acid CAS 21739-92-4
5-Bromo-2-Chloro-4'-Ethoxydiphenylmethane CAS 461432-23-5
2,3,4,6-Tetrakis-O-Trimethylsilyl-D-Gluconolactone CAS 32384-65-9
| Igama Lekhemikhali | I-5-Bromo-2-Chlorobenzoic Acid |
| Omqondofana | 2-Chloro-5-Bromobenzoic Acid |
| Inombolo ye-CAS | 21739-92-4 |
| Inombolo yeCAT | I-RF-PI439 |
| Isimo Sesitoko | Esitokweni, Isikali Sokukhiqiza Sifinyelela Kumathani |
| I-Molecular Formula | I-C7H4BrClO2 |
| Isisindo samangqamuzana | 235.46 |
| I-Melting Point | 154.0 kuye ku-156.0℃ (lit.) |
| Ibhrendi | I-Ruifu Chemical |
| Into | Imininingwane |
| Ukubukeka | I-Off-White to Light Yellow Powder |
| Isivivinyo | ≥99.0% |
| Amanzi (KF) | ≤0.50% |
| Izinsalela ekushiseni | ≤0.30% |
| 2-Chlorobenzoic Acid | ≤0.30% |
| I-2-Chloro-3-Bromobenzoic Acid | ≤0.30% |
| Ukungcola Okuphelele | ≤1.0% |
| Izinga Lokuhlola | I-Enterprise Standard |
| Ukusetshenziswa | I-Intermediate ye-Dapagliflozin (CAS: 461432-26-8), uhlobo lwesifo sikashukela sohlobo II |
Iphakheji: Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina ezitsheni ezivaliwe endaweni epholile neyomile;Vikela ekukhanyeni nakumswakama.
I-5-Bromo-2-Chlorobenzoic Acid (CAS: 21739-92-4) isetshenziswa njengento yokuqala ku-synthesis ye-Dapagliflozin (CAS: 461432-26-8), i-sodium-glucose cotransporter-2 inhibitor ekhethiwe enciphisa izinso. i-glucose reabsorption futhi isetshenziselwa ukwelapha iziguli ezinesifo sikashukela sohlobo II.I-Dapagliflozin iyi-inhibitor enamandla futhi ekhethayo ye-SGLT-2(SLC5A2) ene-EC50 ye-1.1 nM.Inokungena kahle kuwo wonke amaseli e-Caco-2 futhi iyi-substrate ye-P-glycoprotein (P-gp).I-Dapagliflozin yagunyazwa ngo-2012 yi-FDA.
