I-5-Methylisoxazole-4-Carboxylic Acid CAS 42831-50-5 Leflunomide Intermediate Purity >99.0% (HPLC)

Incazelo emfushane:

Igama Lekhemikhali: 5-Methylisoxazole-4-Carboxylic Acid

Synonyms: 5-Methyl-4-Isoxazolecarboxylic Acid

I-CAS: 42831-50-5

Ubumsulwa: >99.0% (HPLC)

I-Crystalline Powder Emhlophe Kuya Kuphuzi Ephuzi, Ayinaphunga

I-Intermediate ye-Leflunomide (CAS: 75706-12-6)

Thintana: UDkt. Alvin Huang

Iselula/Wechat/WhatsApp: +86-15026746401

E-Mail: alvin@ruifuchem.com

Thumela i-imeyili kithi

Imininingwane Yomkhiqizo

Imikhiqizo Ehlobene

Omaka bomkhiqizo

Incazelo:

I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili we-5-Methylisoxazole-4-Carboxylic Acid (CAS: 42831-50-5) enekhwalithi ephezulu.I-Ruifu inganikeza ukulethwa komhlaba wonke, intengo encintisanayo, isevisi enhle kakhulu, amanani amancane kanye nenqwaba etholakalayo.Thenga i-5-Methylisoxazole-4-Carboxylic Acid,Please contact: alvin@ruifuchem.com

Chemical Properties:

Igama Lekhemikhali	I-5-Methylisoxazole-4-Carboxylic Acid
Omqondofana	I-5-Methyl-4-Isoxazolecarboxylic Acid
Ukungcola	I-Leflunomide EP Ukungcola D/Leflunomide BP Ukungcola D
Isimo Sesitoko	Esitokweni, Isikali Sokuhweba
Inombolo ye-CAS	42831-50-5
I-Molecular Formula	C5H5NO3
Isisindo samangqamuzana	127.10 g/mol
I-Melting Point	145.0 kuye ku-149.0℃(lit.)
Ukuminyana	1.348±0.06 g/cm3
Isikhathi Sokugcina.	Indawo epholile neyomile (2~8℃)
I-COA ne-MSDS	Iyatholakala
Ibhrendi	I-Ruifu Chemical

Imininingwane:

Izinto	Amazinga Wokuhlola	Imiphumela
Ukubukeka	I-Crystalline Powder Emhlophe Kuya Kuphuzi Ephuzi, Ayinaphunga	Iyahambisana
I-Melting Point	145.0 ukuze 149.0 ℃	147.8 ~ 148.5 ℃
Ukulahlekelwa Ekumisweni	≤0.50%	0.13%
Izinsalela ekushiseni	≤0.10%	0.04%
Izinsimbi Ezisindayo (Pb)	≤0.002%	<0.002%
3-Methyl Isomeric Compound	≤0.20%	<0.20%
Ukuhlanzeka / Indlela Yokuhlaziya	>99.0% (HPLC)	99.74%
I-Infrared Spectrum	Ivumelana Nesakhiwo	Iyahambisana
1 H NMR Spectrum	Ivumelana Nesakhiwo	Iyahambisana
Isiphetho	Umkhiqizo uhloliwe futhi uthobelana nemibandela enikeziwe
Isebenzisa	I-Pharmaceutical Intermediate ye-Leflunomide (CAS: 75706-12-6)

Iphakheji/Isitoreji/Ukuthumela ngomkhumbi:

Iphakheji:Ibhodlela, isikhwama se-Aluminium foil, 25kg/Cardboard Drum, noma ngokwezidingo zekhasimende.
Isimo Sesitoreji:Gcina esitsheni esivalwe ngci.Gcina endaweni epholile, eyomile (2~8℃) futhi enomoya omuhle kude nezinto ezingahambelani.Vikela ekukhanyeni nakumswakama.
Ukuthumela:Zilethe emhlabeni wonke ngendiza, yi-FedEx/DHL Express.Nikeza ukulethwa okusheshayo nokuthembekile.

Izinzuzo:

Amandla Anele: Izinsiza ezanele kanye nochwepheshe

Isevisi Yobuchwepheshe: Isevisi yokuthenga yokuma eyodwa

Iphakheji le-OEM: Iphakheji yangokwezifiso kanye nelebula iyatholakala

Ukulethwa Okusheshayo: Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe

Impahla Ezinzile: Gcina isitoko esinengqondo

Ukusekelwa Kwezobuchwepheshe: Isixazululo sezobuchwepheshe siyatholakala

Isevisi Yokuhlanganisa Ngokwezifiso: Isukela kumagremu kuye kumakhilo

Ikhwalithi Ephezulu: Kusungulwe uhlelo oluphelele lokuqinisekisa ikhwalithi

I-FAQ:

Indlela Yokuthenga?Sicela uxhumaneDr. Alvin Huang: sales@ruifuchem.com or alvin@ruifuchem.com

Iminyaka engu-15 Yokuhlangenwe nakho?Sinesipiliyoni seminyaka engaphezu kwe-15 ekwakhiweni nasekuthumeleni kwamanye amazwe uhla olubanzi lwezinga eliphezulu lokuxhumanisa imithi noma amakhemikhali amahle.

Izimakethe Eziyinhloko?Thengisa emakethe yasekhaya, eNyakatho Melika, eYurophu, eNdiya, eKorea, eJapane, e-Australia, njll.

Izinzuzo?Ikhwalithi ephezulu, intengo ethengekayo, izinsizakalo ezichwepheshile nokusekelwa kobuchwepheshe, ukulethwa okusheshayo.

IkhwalithiIsiqiniseko?Isistimu yokulawula ikhwalithi eqinile.Imishini yobuchwepheshe yokuhlaziya ifaka i-NMR, LC-MS, GC, HPLC, ICP-MS, UV, IR, NOMA, KF, ROI, LOD, MP, Clarity, Solubility, Microbial limit test, njll.

Amasampula?Imikhiqizo eminingi inikeza amasampula wamahhala wokuhlolwa kwekhwalithi, izindleko zokuthumela kufanele zikhokhelwe amakhasimende.

Ukuhlolwa Kwemboni?Wamukelekile ekucwaningweni kwemboni.Sicela wenze i-aphoyintimenti kusengaphambili.

I-MOQ?Ayikho i-MOQ.I-oda elincane liyamukeleka.

Isikhathi sokuthumela? Uma kungaphakathi kwesitoko, ukulethwa kwezinsuku ezintathu kuqinisekisiwe.

Ezokuthutha?By Express (FedEx, DHL), by Air, by Sea.

Amadokhumenti?Ngemuva kwenkonzo yokuthengisa: I-COA, i-MOA, i-ROS, i-MSDS, njll.

Custom Synthesis?Ingahlinzeka ngezinsizakalo zokwenziwa ngokwezifiso ukuze zilingane kangcono nezidingo zakho zocwaningo.

Imigomo Yokukhokha?I-invoyisi ye-Proforma izothunyelwa kuqala ngemva kokuqinisekiswa kwe-oda, kufakwe nemininingwane yethu yasebhange.Inkokhelo nge-T/T (Telex Transfer), PayPal, Western Union, njll.

42831-50-5 - Ubungozi nokuphepha:

Amakhodi Engozi
R36/37/38 - Ukucasula amehlo, uhlelo lokuphefumula kanye nesikhumba.
R37/38 - Ukucasula uhlelo lokuphefumula kanye nesikhumba.
R36 - Ukucasula emehlweni
I-R10 - Iyavutha
Incazelo Yokuphepha
S22 - Ungaphefumuli uthuli.
S26 - Uma uthintana namehlo, geza ngokushesha ngamanzi amaningi futhi ufune iseluleko sezokwelapha.
I-S36/37/39 - Gqoka izingubo zokuzivikela ezifanele, amagilavu nokuvikela iso/ubuso.
I-S36 - Gqoka izingubo ezifanele zokuzivikela.
S16 - Gcina kude nemithombo yokuthungela.
I-WGK Germany 3
I-HS Code 2917399090
I-Hazard Class IRRITANT

Isicelo:

I-5-Methylisoxazole-4-Carboxylic Acid (i-CAS: 42831-50-5) iphakathi kokuhlanganiswa kwe-Leflunomide (CAS: 75706-12-6).I-Leflunomide iwuhlobo lwezidakamizwa ze-isoxazole immunosuppressive ezinomsebenzi wokulwa nokuvuvukala, i-pharmacology yesimanje ihlukanisa lo mkhiqizo njengezidakamizwa ze-antipyretic, analgesic kanye ne-anti-inflammatory.Lo mkhiqizo ungashintshwa ngokushesha kuma-metabolites asebenzayo futhi ubambe iqhaza ngesibindi kanye ne-cytoplasm yamathumbu nama-microsomes, ayo;Indlela eyinhloko ngesikhathi sokuhlanganiswa kwe-DNA, ivimbela umsebenzi obalulekile we-enzyme-DHODH (DHODH), ukuze ama-nucleotide ngaphakathi kwe-B lymphocyte aphele, inqamule i-biosynthesis ye-DNA ne-RNA, amangqamuzana awakwazi ukungena esigabeni, futhi ekugcineni awakwazi. ukwanda, okuholela emiphumeleni elwa ne-rheumatic, ifaneleka ekwelapheni abantu abadala abane-arthritis esebenzayo, i-ankylosing spondylitis, inganciphisa ukubhujiswa kwamathambo, inciphise izimpawu nezimpawu.Ngaphezu kwalokho, i-leflunomide ingaphinda ivimbele umsebenzi we-tyrosine kinase, ngaleyo ndlela ivimbele ukwanda kwamaseli T, B cell kanye namaseli angenawo amasosha omzimba, kodwa futhi, nge-biosynthesis inhibition ye-cyclooxygenase-2 (COX2), ivimbele ukuhlanganiswa kwe-prostaglandin futhi isebenzise i-anti- imiphumela yokuvuvukala futhi ivimbele amaseli e-mast kanye nokukhululwa kwe-basophils histamine.Lapho lo mkhiqizo usetshenziswa ezigulini zokufakelwa kwesitho, ukulungiswa komthamo kunzima, kusetshenziselwa ikakhulukazi ukwelapha isifo samathambo nezinye izifo ezizimele.