5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid CAS 4242-18-6 Ubumsulwa >99.0% (HPLC) Palonosetron Hydrochloride Intermediate
I-Shanghai Ruifu Chemical Co., Ltd. ingumkhiqizi ohamba phambili kanye nomphakeli we-5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid (CAS: 4242-18-6) enekhwalithi ephezulu.Singahlinzeka nge-COA, ukulethwa komhlaba wonke, amanani amancane kanye nenqwaba etholakalayo.Uma unentshisekelo kulo mkhiqizo, sicela uthumele imininingwane enemininingwane ehlanganisa inombolo ye-CAS, igama lomkhiqizo, nenani kithi.Please contact: alvin@ruifuchem.com
Igama Lekhemikhali | 5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid |
Omqondofana | 5,6,7,8-Tetrahydro-1-Naphthalenecarboxylic Acid;5,6,7,8-Tetrahydro-Naphthalene-1-Carboxylic Acid;5,6,7,8-Tetrahydro-1-Naphthoic Acid |
Isimo Sesitoko | Esitokweni, Amandla Okukhiqiza Amathani |
Inombolo ye-CAS | 4242-18-6 |
I-Molecular Formula | I-C11H12O2 |
Isisindo samangqamuzana | 176.22 |
I-Melting Point | 148.0~152.0℃ |
Iphuzu elibilayo | 336.8±31.0℃ |
Ukuminyana | 1.184±0.06 g/cm3 |
Isimo Sokuthumela | Amazinga Okushisa e-Ambient |
I-COA ne-MSDS | Iyatholakala |
Ibhrendi | I-Ruifu Chemical |
Into | Izinga Lokuhlola | Imiphumela |
Ukubukeka | I-Crystalline Powder Emhlophe noma Cishe Emhlophe | Kuthotshelwe |
Ukulahlekelwa Ekumisweni | <1.00% | 0.67% |
Izinsalela ekushiseni | <0.20% | 0.03% |
I-Melting Point | 148.0~152.0℃ | 149.9 ~ 150.9 ℃ |
Ubumsulwa (HPLC) | >99.0% (HPLC) | 99.9% |
Isivivinyo | 98.0~101.0% (Neutralization Titration) | 100.9% |
1 H NMR Spectrum | Ihambisana Nesakhiwo | |
Isiphetho | Lo Mkhiqizo Ngokuhlola Uvumelana Nezinga Lebhizinisi | |
Ukusetshenziswa Okuyinhloko | I-Intermediate ye-Palonosetron Hydrochloride (CAS: 135729-62-3) |
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I-5,6,7,8-Tetrahydronaphthalene-1-Carboxylic Acid (CAS: 4242-18-6) iyindawo ephakathi esetshenziselwa ukulungiswa kwe-ejenti ye-antiemetic ewusizo yokwelapha i-Palonosetron Hydrochloride (CAS: 135729-62-3).I-Palonosetron Hydrochloride iyisidakamizwa sokuvimbela isicanucanu nokuhlanza, okuwuhlobo olusha olukhetha kakhulu, olusondelene kakhulu ne-5-HT3 receptor antagonist engavimba isikhungo sokuhlanza i-reflex peripheral neurons presynaptic 5-HT.Ukujabula kwesamukeli kuthinta ngokuqondile isimiso sezinzwa esimaphakathi ku-5-HT.Injabulo ye-impulse receptor ekhiqizwa indima ye-vagal afferent nerve ngemva kwendawo, ivimba iziphetho ze-vagus nerve emathunjini, ivimbela amasignali ku-5-HT.I-receptor trigger zone inganciphisa izehlakalo zokucanuzela kwenhliziyo nokuhlanza.Central Clinically yokwelashwa kwe-acute emetogenic chemotherapy ebangela ukubambezeleka kwesicanucanu nokuhlanza.Ngenxa yomphumela wayo ophezulu wokwelapha, umphumela omncane ongathandeki, impilo ende yesigamu (cishe 40 h), umthamo omncane, nokunye, kuye kwakhanga ukunaka okukhulu.